Macroscopic supramolecular assembly to fabricate multiplexed DNA patterns for potential application in DNA chips

Nanoscale ◽  
2017 ◽  
Vol 9 (44) ◽  
pp. 17220-17223 ◽  
Author(s):  
Mengjiao Cheng ◽  
Yingwei Zhang ◽  
Song Wang ◽  
Feng Shi
Keyword(s):  
Potential Application ◽  
Dna Microarrays ◽  
Supramolecular Assembly ◽  
Dna Chips ◽  
Multiple Targets

We have established a macroscopic supramolecular assembly methodology for the fabrication of DNA microarrays to detect multiple targets without contamination.

Supramolecular Assembly of Functional Cholesteryl Substituted Luminol Derivative in Organized Molecular Films

2012 ◽  
Vol 581-582 ◽  
pp. 176-179
Author(s):  
Jing Xin Zhou ◽  
Ti Feng Jiao ◽  
Adan Li ◽  
Yuan Yuan Xing
Keyword(s):  
Ir Spectra ◽  
Potential Application ◽  
Water Surface ◽  
Supramolecular Assembly ◽  
Cd Spectra ◽  
Functional Material ◽  
Lb Films ◽  
Uv And Ir Spectra ◽  
Imide Group ◽  
Luminol Derivative

Functional luminol derivative with cholesteryl substituted group has been designed and synthesized from the reaction of the corresponding precursor cholesteryl chloroformate with luminol. This compound can be spread on water surface to form stable monolayer. It has been found that UV and IR spectra confirmed the characteristic aromatic segment, imide group and cholesteryl substituted group. In addition, the CD spectra also showed positive CD signals, which may be attributed to the chiral cholesteryl substituted groups. AFM investigation indicated some aggregated domains with the averaged height about 3.6  0.2 nm appeared. This suggested an organized structure of double molecules may be fabricated in the transferred LB films. The present results have demonstrated that the interfacial properties of luminol derivative can be modified by changing proper substituted groups of luminol, which show potential application in functional material fields such as ECL sensor.

A lanthanide-based magnetic nanosensor as an erasable and visible platform for multi-color point-of-care detection of multiple targets and the potential application by smartphone

2019 ◽  
Vol 7 (5) ◽  
pp. 734-743 ◽  
Author(s):  
Jun Xu ◽  
Xiao-Ke Shen ◽  
Lei Jia ◽  
Jian-Liang Cao ◽  
Yan Wang ◽  
...  
Keyword(s):  
Potential Application ◽  
Point Of Care ◽  
Multiple Targets ◽  
Color Detection ◽  
Point Of Care Detection

A magnetic Fe3O4@CePO4:Tb-EDTA-Eu nanosensor as an erasable and visible platform for the multi-color detection of multiple targets was designed.

The 3-Dimensional Molecular Structure of the Actin Filament Revisited

1985 ◽  
Vol 43 ◽  
pp. 480-481
Author(s):  
U. Aebi ◽  
R. Millonig ◽  
H. Salvo
Keyword(s):  
Actin Filament ◽  
Supramolecular Assembly ◽  
Specimen Preparation ◽  
X Ray Diffraction ◽  
Single Filament ◽  
X Ray ◽  
3 Dimensional ◽  
Filament Diameter ◽  
Preparation Conditions ◽  
Apparent Diameter

To date, most 3-D reconstructions of undecorated actin filaments have been obtained from actin filament paracrystal data (for refs, see 1,2). However, due to the fact that (a) the paracrystals may be several filament layers thick, and (b) adjacent filaments may sustantially interdigitate, these reconstructions may be subject to significant artifacts. None of these reconstructions has permitted unambiguous tracing or orientation of the actin subunits within the filament. Furthermore, measured values for the maximal filament diameter both determined by EM and by X-ray diffraction analysis, vary between 6 and 10 nm. Obviously, the apparent diameter of the actin filament revealed in the EM will critically depend on specimen preparation, since it is a rather flexible supramolecular assembly which can easily be bent or distorted. To resolve some of these ambiguities, we have explored specimen preparation conditions which may preserve single filaments sufficiently straight and helically ordered to be suitable for single filament 3-D reconstructions, possibly revealing molecular detail.

Post-mortem Peyer’s patches: Their potential application in forensic medicine

2009 ◽  
Vol 00 (00) ◽  
pp. 090513010017019-7
Author(s):  
Biagio Solarino ◽  
Giancarlo Di Vella ◽  
Thea Magrone ◽  
Felicita Jirillo ◽  
Angela Tafaro ◽  
...  
Keyword(s):  
Forensic Medicine ◽  
Potential Application ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Post Mortem

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

Eye movement in response to single and multiple targets.

1985 ◽  
Author(s):  
R. V. Kenyon ◽  
Y. Y. Zeevi ◽  
P. A. Wetzel ◽  
L. R. Young
Keyword(s):  
Eye Movement ◽  
Multiple Targets

Visual search for multiple targets gives no evidence of amnesic covert attention

2001 ◽  
Author(s):  
Jason S. McCarley ◽  
Matthew S. Peterson ◽  
Arthur F. Kramer ◽  
Ranxiao Frances Wang ◽  
David E. Irwin
Keyword(s):  
Visual Search ◽  
Covert Attention ◽  
Multiple Targets

Comparison of Caseinolytic and Fibrinolytic Assays for Plasmin (Fibrinolysin) in “Fibrinolytic Agents”

1966 ◽  
Vol 15 (01/02) ◽  
pp. 252-272
Author(s):  
K. M Moser ◽  
Mary Belle Frey
Keyword(s):  
Linear Relationship ◽  
Potential Application ◽  
Fibrinolytic Agents ◽  
Linear Portion

Summary1. Caseinolytic and fibrinolytic systems for assay of plasmin in fibrinolytic agents are described which are based upon the determinations of AE/min during the linear portion of the casein-plasmin and fibrin-plasmin reaction curves respectively. A " caseinolytic-rate " unit and “fibrinolytic-rate " unit of ÄE/min × 103 during the linear portion of the respective curves are proposed.2. Data are presented indicating that a reliably linear relationship exists between plasmin concentration and these caseinolytic - and fibrinolytic-rate units.3. Data comparing results obtained with the proposed assay techniques and previously-used casein and fibrinolytic techniques are presented.4. Formulae by which caseinolytic-rate and fibrinolytic-rate units can be roughly converted into Remmert-Cohen type plasmin units are offered.5. The theoretical and practical problems which have influenced development of assays for fibrinolytic components are discussed.6. The advantages of the plasmin “rate unit” techniques vis a vis existing assays are delineated.7. The potential application of the techniques to measurements other than the plasmin content of fibrinolytic agents is discussed.

Can DNA microarrays change diagnostics and therapy of lung cancer?

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
HS Hofmann ◽  
A Simm ◽  
G Hansen ◽  
RJ Scheubel ◽  
RE Silber ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Microarrays ◽  
Diagnostics And Therapy
Sign in / Sign up

Export Citation Format

Share Document