scholarly journals Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

2017 ◽  
Vol 8 (34) ◽  
pp. 4983-4987 ◽  
Author(s):  
Jawaher A. Alfurhood ◽  
Hao Sun ◽  
Christopher P. Kabb ◽  
Bryan S. Tucker ◽  
James H. Matthews ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Polymer Carrier ◽  
Biological Compatibility ◽  
Hydroxypropyl Methacrylamide

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units.

Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

2015 ◽  
Vol 6 (13) ◽  
pp. 2386-2389 ◽  
Author(s):  
Suchithra A. Senevirathne ◽  
Suthida Boonsith ◽  
David Oupicky ◽  
Michael C. Biewer ◽  
Mihaela C. Stefan
Keyword(s):  
Valproic Acid ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Histone Deacetylase ◽  
Hdac Inhibitors ◽  
Research Direction ◽  
Synthesis And Characterization ◽  
Covalent Bonds ◽  
New Research

The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment.

Block Copolymer Concentration Gradient and Solvent Effects on Nanostructuring of Thin Epoxy Coatings Modified with Epoxidized Styrene–Butadiene–Styrene Block Copolymers

2012 ◽  
Vol 45 (3) ◽  
pp. 1483-1491 ◽  
Author(s):  
José Angel Ramos ◽  
Leandro H. Espósito ◽  
Raquel Fernández ◽  
Iñaki Zalakain ◽  
Silvia Goyanes ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Solvent Effects ◽  
Concentration Gradient ◽  
Epoxy Coatings ◽  
Copolymer Concentration ◽  
Styrene Butadiene Styrene ◽  
Styrene Butadiene ◽  
Butadiene Styrene

Interactions in block copolymers in solution: The effect of hetero-contacts on the segmental interactions in block copolymers of poly(isoprene : styrene) in solution

1969 ◽  
Vol 22 (8) ◽  
pp. 1649 ◽  
Author(s):  
JR Urwin
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Linear Relation ◽  
Sequence Block ◽  
Cluster Integrals ◽  
Excluded Volumes

Binary cluster integrals or excluded volumes for chemically different segment pairs in block copolymers of poly(isoprene : styrene) have been calculated from the equation derived by Froelich and Benoit for a two- sequence block copolymer. Expansion factors have been recalculated assuming a linear relation for [η]θ with respect to composition employing published values for polystyrene and polyisoprene. The results are discussed in relation to possible conformations of block copolymers.

scholarly journals Characterizing block-copolymer micelles used in nanomedicines via solution static scattering techniques

2021 ◽  
Author(s):  
Isamu Akiba ◽  
Kazuo Sakurai
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Static Solution ◽  
Theoretical Background ◽  
Hydrophobic Drugs ◽  
Safety And Efficacy ◽  
Critical Quality Attributes ◽  
Regulatory Authorities ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

AbstractBlock copolymers are well recognized as excellent nanotools for delivering hydrophobic drugs. The formulation of such delivery nanoparticles requires robust characterization and clarification of the critical quality attributes correlating with the safety and efficacy of the drug before applying to regulatory authorities for approval. Static solution scattering from block copolymers is one such technique. This paper first outlines the theoretical background and current models for analyzing this scattering and then presents an overview of our recent studies on block copolymers.

scholarly journals Engineering block copolymer materials for patterning ultra-low dimensions

2020 ◽  
Vol 5 (10) ◽  
pp. 1642-1657
Author(s):  
Cian Cummins ◽  
Guillaume Pino ◽  
Daniele Mantione ◽  
Guillaume Fleury
Keyword(s):  
Thin Film ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Low Dimensions ◽  
Processing Strategies ◽  
Synthetic Routes ◽  
Film Processing ◽  
Thin Film Processing

Recently engineered high χ-low N block copolymers for nanolithography are evaluated. Synthetic routes together with thin film processing strategies are highlighted that could enable the relentless scaling for logic technologies at sub-10 nanometres.

Effect of block copolymer architecture on compatibility: 2. Epoxidized styrene-butadiene star block copolymers with chlorinated polymers

Polymer ◽  
1994 ◽  
Vol 35 (7) ◽  
pp. 1425-1432 ◽  
Author(s):  
Stathis N. Koklas ◽  
Kostas G. Gravalos ◽  
Nikos K. Kalfoglou
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Star Block Copolymers ◽  
Styrene Butadiene

Basic Understanding of Phase Behavior and Structure of Silicone Block Copolymers and Surfactant–Block Copolymer Mixtures

2008 ◽  
pp. 391-417 ◽  
Author(s):  
Carlos Rodrguez ◽  
Arturo Lpez-Quintela ◽  
Md. Hemayet Uddin ◽  
Kenji Aramaki ◽  
Hironobu Kunieda
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Phase Behavior ◽  
Basic Understanding

The Properties of a Styrene Butadiene Block Copolymer with a High Styrene Content

2014 ◽  
Vol 41 (10) ◽  
pp. 45-50
Author(s):  
A.A. Alekseev ◽  
A.V. Lobanov ◽  
V.S. Osipchik ◽  
V.S. Glukhovskoi ◽  
V.M. Aristov ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Absorption Band ◽  
Ir Spectra ◽  
Structure And Properties ◽  
Styrene Content ◽  
Styrene Butadiene ◽  
Butadiene Styrene

The structure and properties of block copolymers (BCPs) of styrene and butadiene of grade StiroTEP-70 (styrene:butadiene = 70:30, Mw/Mn = 1.43–1.45) are discussed. Analysis of IR spectra enables the BCP to be treated as polystyrene-stat-copoly(butadiene/styrene/1,2-butadiene)-polystyrene. It is suggested that the absorption band at 542 cm-1 be considered as characteristic when identifying polymers with extensive polystyrene phases. At temperatures of 190–230°C, the BCP is partially crosslinked, and at 260°C it breaks down. The BCP is processed well at temperatures up to 200°C.

Solvent Effects on the Synthesis of Polymeric Nanoparticles via Block Copolymer Self-Assembly Using Microporous Membranes

2020 ◽  
Vol 1000 ◽  
pp. 324-330
Author(s):  
Sri Agustina ◽  
Masayoshi Tokuda ◽  
Hideto Minami ◽  
Cyrille Boyer ◽  
Per B. Zetterlund
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Self Assembly ◽  
Polymeric Nanoparticles ◽  
Raft Polymerization ◽  
Membrane Emulsification ◽  
Membrane Pore ◽  
Novel Technique ◽  
Wide Range ◽  
Membrane Pore Size

The self-assembly of block copolymers has attracted attention for many decades because it can yield polymeric nanoobjects with a wide range of morphologies. Membrane emulsification is a fairly novel technique for preparation of various types of emulsions, which relies on the dispersed phase passing through a membrane in order to effect droplet formation. In this study, we have prepared polymeric nanoparticles of different morphologies using self-assembly of asymmetric block copolymers in connection with membrane emulsification. Shirasu Porous Glass (SPG) membranes has been employed as the membrane emulsification equipment, and poly (oligoethylene glycol acrylate)-block-poly (styrene) (POEGA-b-PSt) copolymers prepared via RAFT polymerization. It has been found that a number of different morphologies can be achieved using this novel technique, including spheres, rods, and vesicles. Interestingly, the results have shown that the morphology can be controlled not only by adjusting experimental parameters specific to the membrane emulsification step such as membrane pore size and pressure, but also by changing the nature of organic solvent. As such, this method provides a novel route to these interesting nanoobjects, with interesting prospects in terms of exercising morphology control without altering the nature of the block copolymer itself.

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