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2022 ◽  
Vol 150 ◽  
pp. 106879
L. Esposito ◽  
A. Bertocco ◽  
M. Bruno ◽  
A. Ruggiero

Amal R. Tantawy

Abstract Background This research paper contributes to presenting a proposed framework for the formal and structural specifications of parametric digital architecture in order to increase knowledge and know-how in this field closely to specialists and those interested in it through the research methodology, which is divided first into the theoretical background to include a presentation of the definition of digital architecture and the most important pioneers of digital architecture, digital building materials and construction mechanisms parametric digital and what are the most important computer software used in parametric digital architecture in terms of design and construction implementation and identifying the most important digital specifications and characteristics that were mentioned in previous studies in this field and what are the unconventional digital esthetic values, then comes the role of the applied study in formulating a comprehensive matrix of parametric design modern and its impact on the development of traditional architectural models in digital architecture. Results The research study found that both (unrealistic shape) and (typical interaction) ranked first with the highest percentage reaching 100% in all study cases. The ratio of the volume of each to the total volume of all elements of morphological characteristics and non-traditional esthetic values was 8%, the most important characteristic of buildings in parametric digital architecture, in most of them, is the lack of realism to a very significant degree, and we always find a clear increase in the interaction, vitality and dynamism of buildings with the surrounding environment. Conclusions The most important characteristic of buildings in parametric digital architecture, in most of them, is the lack of realism to a very significant degree, and we always find a clear increase in the interaction, vitality and dynamism of buildings with the surrounding environment. While we conclude that the least characteristic of the parametric digital buildings is the simulation of nature or the tendency to everything that is traditional, as well it is often inclined to everything strange and unfamiliar.

2022 ◽  
Vol 6 (1) ◽  
pp. 10
Matej Vuković ◽  
Stefan Thalmann

Industry 4.0 radically alters manufacturing organization and management, fostering collection and analysis of increasing amounts of data. Advanced data analytics, such as machine learning (ML), are essential for implementing Industry 4.0 and obtaining insights regarding production, better decision support, and enhanced manufacturing quality and sustainability. ML outperforms traditional approaches in many cases, but its complexity leads to unclear bases for decisions. Thus, acceptance of ML and, concomitantly, Industry 4.0, is hindered due to increasing requirements of fairness, accountability, and transparency, especially in sensitive-use cases. ML does not augment organizational knowledge, which is highly desired by manufacturing experts. Causal discovery promises a solution by providing insights on causal relationships that go beyond traditional ML’s statistical dependency. Causal discovery has a theoretical background and been successfully applied in medicine, genetics, and ecology. However, in manufacturing, only experimental and scattered applications are known; no comprehensive overview about how causal discovery can be applied in manufacturing is available. This paper investigates the state and development of research on causal discovery in manufacturing by focusing on motivations for application, common application scenarios and approaches, impacts, and implementation challenges. Based on the structured literature review, four core areas are identified, and a research agenda is proposed.

2022 ◽  
Vol 23 (2) ◽  
pp. 797
Tatiana Michel ◽  
Markus Ollert ◽  
Jacques Zimmer

Despite significant progress in recent years, the therapeutic approach of the multiple different forms of human cancer often remains a challenge. Besides the well-established cancer surgery, radiotherapy and chemotherapy, immunotherapeutic strategies gain more and more attention, and some of them have already been successfully introduced into the clinic. Among these, immunotherapy based on natural killer (NK) cells is considered as one of the most promising options. In the present review, we will expose the different possibilities NK cells offer in this context, compare data about the theoretical background and mechanism(s) of action, report some results of clinical trials and identify several very recent trends. The pharmaceutical industry is quite interested in NK cell immunotherapy, which will benefit the speed of progress in the field.

2022 ◽  
Vol 2 ◽  
Fernando Renee González Moraga ◽  
Stéphanie Klein Tuente ◽  
Sean Perrin ◽  
Pia Enebrink ◽  
Kristina Sygel ◽  

Aggression is a known problem in individuals being cared for in forensic settings, yet the evidence base for its treatment is scarce. Virtual Reality (VR) has been proposed as a promising addition to interventions in forensic settings, as it may increase the motivation among participants, bridge the gap between real life, therapeutic and laboratory experiences, and increase the ecological validity of psychological research. Recently, a new treatment for aggression using VR as the treatment environment, Virtual Reality Aggression Prevention Training (VRAPT), was developed to provide realistic and safe environments for participants to practice aggression management. In its current revised version, VRAPT is conceptualized as a form of cognitive behavioral therapy with its theoretical background in the General Aggression Model. Its purpose is to increase awareness of, and improve control over, one’s own aggression and that of others through social interactions in individually tailored virtual environments. This manuscript describes how the lessons learned from the first randomized controlled trial of VRAPT have been applied to further develop the method and discusses challenges and future directions for VR-assisted treatment of aggression in forensic settings. VRAPT is a new psychological treatment for aggression and the coming years will provide expanded scientific evidence for further developments and adaptations.

2022 ◽  
Vol 10 (1) ◽  
pp. 182-192
Sebastian Jirgl

This paper aims to examine the impact and overlap of the philosophy of Emmanuel Levinas in connection with the issue of determining others in contemporary modern society, especially in relation to ethical theoretical background and real political practice. This paper aims to relate Levinasian philosophy to the phenomena of contemporary modern society, specifically, its ethics and political practice. This paper intends to capture the relevance of Levinasian philosophy to our current political and religious conflicts, the issue of refugees, immigrants, and the phenomenon of mass migration. In a broader sense, it also reflects upon the issues of racism and globalization as pertinent issues in our current age.


Este estudio preliminar funciona como contextualización sintética de la sección monográfica, planteando las premisas iniciales y una fundamentación teórico-crítica. La pretensión es doble: plasmar la necesidad de defensa de la existencia de una tradición femenina en el ámbito de la literatura de lo irreal y sintetizar los aspectos esenciales que conviene considerar en el análisis de dicha creación en el siglo XXI, entre ellos el hibridismo genérico, la significación del espacio doméstico y corporal, la relevancia de las voces narradoras de mujer, el protagonismo femenino con una marcada agencia, el modo de abordar la monstruosidad, así como las perspectivas feministas y de compromiso social y político.  Abstract: This preliminary study serves as a brief contextual framework of the following monographic section, including its cornerstones and a theoretical background. It has two goals: the claim of a female tradition in the field of unreal literature, and a synthesis of the essential aspects which must be taken into account in the analysis of this type of writing in the 21st Century, including genre hybridity, domestic and corporeal space signification, the relevance of women’s narrative, the prominence of female characters as agents, the ways in which monstrosity is tackled, as well as feminist, social and politically engagée perspectives.

2022 ◽  
Vol 2 ◽  
pp. 3
Markku Pirttijärvi ◽  
Ari Saartenoja ◽  
Pekka Korkeakangas

Geophysical electromagnetic (EM) methods are used in geological mapping, mineral exploration, groundwater studies and geotechnical investigations. Airborne EM methods have the benefit of avoiding terrain obstacles such as lakes, rivers, swamps, and ravines. Compared to manned aircrafts, drones or unmanned aerial vehicles (UAVs) have benefits of their own. Drone-based surveys are versatile, fast to deploy, economical and ecologically more friendly. Presently, magnetic surveying is the only geophysical method that is routinely conducted with drones. The modest maximum payload limit of drones imposes severe restrictions on the applicability of other methods including EM and radiometric methods, for example. Finnish company, Radai Ltd has been developing Louhi, a novel drone-based frequency-domain EM survey system, in an EU funded Horizon 2020 project NEXT – New Exploration Technologies. The EM system has two operation options – the first uses a large loop on the ground as an EM source and the other uses a small portable EM transmitter loop. Both systems utilize a stand-alone and light-weight three-component EM receiver that can be towed by a drone. This article presents the theoretical background of the EM methods, the solution developed by Radai Ltd, the current version of the EM device, and results from field and flight tests that demonstrate the applicability of the drone-based EM system under development.

2022 ◽  
Vol 12 (1) ◽  
pp. 43-50
Yomna Daoud ◽  
Aida Kammoun

This paper investigates whether regulatory pressures have an impact on the relationship between change in capital and bank risk-taking. On the basis of a well developed theoretical background, capital regulation constitutes the core of prudential regulation within the banking sector. Several researches have investigated this relationship between capital and risk in conventional banks, and this subject has gained in interest since the last financial crisis. This study is one of the few studies that have attempted to provide empirical evidence on this issue for Islamic banks. We use data of Islamic banking sectors over the period 2010–2014. The results reveal that Islamic banks tend to behave differently at each level of capital adequacy. In addition, we provide some evidence that change in capital is positively related to the change in risk for highly capitalized Islamic banks.

2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Paulo Dias ◽  
Sílvia Lopes ◽  
Ricardo Peixoto

Purpose This study aims to examine the associations among mastering new technologies, teleworkers’ voluntariness and involuntariness and employee well-being (i.e. work engagement and exhaustion). To the best of the authors’ knowledge, no studies have explored the relationships among these constructs in the same conceptual model. Design/methodology/approach Data were collected from a sample of 451 individuals performing telework in Portugal. AMOS was used to test all hypotheses of the study. Findings The findings showed a positive relationship between mastering new technologies and teleworkers’ voluntariness and a negative relationship between mastering new technologies and teleworkers’ involuntariness. However, contrary to expectations, voluntariness in teleworking was not significantly related to either work engagement or exhaustion. However, consistent with the theoretical background of self-determination theory, involuntariness in teleworking was negatively related to work engagement and positively related to exhaustion. Originality/value This study contributes to the literature by addressing the analysis of telework-related variables that may impact workers’ well-being. Implications for human resource management policies and knowledge management are discussed.

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