Characterizing block-copolymer micelles used in nanomedicines via solution static scattering techniques

AbstractBlock copolymers are well recognized as excellent nanotools for delivering hydrophobic drugs. The formulation of such delivery nanoparticles requires robust characterization and clarification of the critical quality attributes correlating with the safety and efficacy of the drug before applying to regulatory authorities for approval. Static solution scattering from block copolymers is one such technique. This paper first outlines the theoretical background and current models for analyzing this scattering and then presents an overview of our recent studies on block copolymers.

Block copolymer micelles as delivery vehicles of hydrophobic drugs: Micelle–cell interactions

Journal of Drug Targeting ◽

10.1080/10611860600874538 ◽

2006 ◽

Vol 14 (6) ◽

pp. 343-355 ◽

Cited By ~ 166

Author(s):

Radoslav Savić ◽

Adi Eisenberg ◽

Dusica Maysinger

Keyword(s):

Block Copolymer ◽

Cell Interactions ◽

Hydrophobic Drugs ◽

Delivery Vehicles ◽

Silica/organosilica cross-linked block copolymer micelles: a versatile theranostic platform

Chemical Society Reviews ◽

10.1039/c6cs00495d ◽

2017 ◽

Vol 46 (3) ◽

pp. 569-585 ◽

Cited By ~ 61

Author(s):

Dechao Niu ◽

Yongsheng Li ◽

Jianlin Shi

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Hybrid Materials ◽

Biomedical Applications ◽

Recent Progress ◽

Amphiphilic Block Copolymers ◽

Cross Linking ◽

Design Synthesis ◽

Silica/organosilica cross-linked block copolymer micelles are a novel class of hybrid materials that combine the advantages of amphiphilic block copolymers and silica/organosilica cross-linking agents into one unit. This Tutorial Review summarizes the recent progress in the design, synthesis and biomedical applications of various silica/organosilica cross-linked block copolymer micelles.

Aggregation-induced emission from the crowded coronal chains of block copolymer micelles

Polymer Chemistry ◽

10.1039/d0py00432d ◽

2020 ◽

Vol 11 (29) ◽

pp. 4706-4713 ◽

Cited By ~ 1

Author(s):

Siyu Wang ◽

Bixin Jin ◽

Gangfeng Chen ◽

Yunjun Luo ◽

Xiaoyu Li

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Self Assembly ◽

The Self ◽

Assembly Process ◽

Spatial Confinement ◽

Aggregation Induced Emission ◽

Aggregation-induced emission (AIE) was triggered via the spatial confinement in the coronal chains in block copolymers upon micellization, even with very low content of AIE groups attached, and this could be used to monitor the self-assembly process.

Superior proapoptotic activity of curcumin-loaded mixed block copolymer micelles with mitochondrial targeting properties

Biomaterials Science ◽

10.1039/c8bm00644j ◽

2018 ◽

Vol 6 (12) ◽

pp. 3309-3317 ◽

Cited By ~ 9

Author(s):

Denitsa Momekova ◽

Iva Ugrinova ◽

Marta Slavkova ◽

Georgi Momekov ◽

Georgy Grancharov ◽

...

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Mixed Block ◽

Mitochondrial Targeting ◽

Multifunctional micelles based on two co-assembled block copolymers are proven to effectively accumulate and deliver curcumin in mitochondria, thus, inducing a much higher proapoptotic activity than single copolymer micelles.

Freezing-induced ordering of block copolymer micelles

Chemical Communications ◽

10.1039/c4cc05556j ◽

2014 ◽

Vol 50 (83) ◽

pp. 12572-12574 ◽

Cited By ~ 16

Author(s):

Jérémy Dhainaut ◽

Giulia Piana ◽

Sylvain Deville ◽

Christian Guizard ◽

Michaela Klotz

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Self Assembly ◽

Assembly Process ◽

Silica Monoliths ◽

Copolymer Micelles ◽

Ice Templating

Silica monoliths presenting both hierarchical and mesostructured porosity were obtained by the combination of ice-templating and block-copolymers following a freezing-induced self-assembly process.

Intensely phosphorescent block copolymer micelles containing gold(i) complexes

Soft Matter ◽

10.1039/c8sm00314a ◽

2018 ◽

Vol 14 (18) ◽

pp. 3521-3527 ◽

Cited By ~ 3

Author(s):

Pingxia Guo ◽

Qun He ◽

Chen Wang ◽

Zaili Hou ◽

Bingran Yu ◽

...

Keyword(s):

Molecular Weight ◽

Block Copolymer ◽

Block Copolymers ◽

Luminescence Enhancement ◽

Copolymer Micelles ◽

Cationic Gold

Micellization of anionic block copolymers with cationic gold(i) complexes induces remarkable phosphorescence enhancement in solution. The extent of the luminescence enhancement increases with increasing molecular weight of the anionic block.

Shaping block copolymer micelles by supramolecular polymerization: making ‘tubisomes’

Polymer Chemistry ◽

10.1039/c9py00179d ◽

2019 ◽

Vol 10 (20) ◽

pp. 2616-2625 ◽

Cited By ~ 11

Author(s):

Johannes C. Brendel ◽

Sylvain Catrouillet ◽

Joaquin Sanchis ◽

Katrina A. Jolliffe ◽

Sébastien Perrier

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Cyclic Peptide ◽

Peptide Conjugates ◽

Cylindrical Micelles ◽

Copolymer Micelles ◽

Supramolecular Polymerization

In contrast to the respective block copolymers, amphiphilic cyclic peptide conjugates self-assemble into cylindrical micelles independent of the polymer compositions.

The Core Composition of DNA Block Copolymer Micelles Dictates DNA Hybridization Properties, Nuclease Stabilities, and Cellular Uptake Efficiencies

Nanoscale ◽

10.1039/d1nr00756d ◽

2021 ◽

Author(s):

Chan-Jin Kim ◽

Ga-Hyun Kim ◽

Eun Hye Jeong ◽

Hyukjin Lee ◽

So-Jung Park

Keyword(s):

Block Copolymer ◽

Block Copolymers ◽

Cellular Uptake ◽

Molecular Interactions ◽

Dna Hybridization ◽

Hydrophobic Core ◽

The Core ◽

Core Composition ◽

Here, we report how the nature of the hydrophobic core affects molecular interactions of DNA block copolymer assemblies. Three different amphiphilic DNA block copolymers, DNA-b-polystyrene (DNA-b-PS), DNA-b-poly(2-vinylpyridine) (DNA-b-P2VP), and DNA-b-poly(methyl...