Albumin/sulfonamide stabilized iron porphyrin metal organic framework nanocomposites: targeting tumor hypoxia by carbonic anhydrase IX inhibition and T1–T2 dual mode MRI guided photodynamic/photothermal therapy

2018 ◽  
Vol 6 (2) ◽  
pp. 265-276 ◽  
Author(s):  
Wei Zhu ◽  
Yao Liu ◽  
Zhe Yang ◽  
Li Zhang ◽  
Liji Xiao ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Tumor Hypoxia ◽  
Carbonic Anhydrase Ix ◽  
Iron Porphyrin ◽  
Dual Mode ◽  
Metal Organic ◽  
Mri Guided ◽  
Organic Framework

We report BSA and SA stabilized iron porphyrin MOF nanocomposites with tremendous potential in tumor hypoxic imaging guided PDT and PTT.

scholarly journals Dual-mode humidity detection using a lanthanide-based metal–organic framework: towards multifunctional humidity sensors

2017 ◽  
Vol 53 (32) ◽  
pp. 4465-4468 ◽  
Author(s):  
Yuan Gao ◽  
Pengtao Jing ◽  
Ning Yan ◽  
Michiel Hilbers ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Humidity Sensor ◽  
Metal Organic Framework ◽  
Dual Mode ◽  
Humidity Sensors ◽  
Highly Effective ◽  
Metal Organic ◽  
Spectroscopy Studies ◽  
Organic Framework

Combined photoluminescence and impedance spectroscopy studies show that a europium-based metal–organic framework behaves as a highly effective and reliable humidity sensor, enabling dual-mode humidity detection.

Nanoscaled porphyrinic metal–organic framework for photodynamic/photothermal therapy of tumor

2019 ◽  
Vol 40 (16-17) ◽  
pp. 2204-2210 ◽  
Author(s):  
Shengyan Wang ◽  
Weihua Chen ◽  
Chunhuan Jiang ◽  
Lehui Lu
Keyword(s):  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

A yolk–shell structured metal–organic framework with encapsulated iron-porphyrin and its derived bimetallic nitrogen-doped porous carbon for an efficient oxygen reduction reaction

2020 ◽  
Vol 8 (19) ◽  
pp. 9536-9544 ◽  
Author(s):  
Chaochao Zhang ◽  
Hao Yang ◽  
Dan Zhong ◽  
Yang Xu ◽  
Yanzhi Wang ◽  
...  
Keyword(s):  
Oxygen Reduction Reaction ◽  
Oxygen Reduction ◽  
Porous Carbon ◽  
Metal Organic Framework ◽  
Reduction Reaction ◽  
Iron Porphyrin ◽  
Zeolitic Imidazolate Framework ◽  
Nitrogen Doped ◽  
Metal Organic ◽  
Organic Framework

A yolk–shell structured metal–organic framework (MOF) with encapsulated 5,10,15,20-tetraphenylporphyrinatoiron (FeTPP) in a zeolitic imidazolate framework (ZIF)-L-ZIF-8 is reported.

scholarly journals Metal–Organic Framework-Based Chemo-Photothermal Combinational System for Precise, Rapid, and Efficient Antibacterial Therapeutics

Pharmaceutics ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 463 ◽  
Author(s):  
Wu ◽  
Fu ◽  
Zhou ◽  
Wang ◽  
Feng ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Global Public Health ◽  
Zeolitic Imidazolate Frameworks ◽  
Porous Carrier ◽  
Metal Organic ◽  
Organic Framework

Rapid increase of antimicrobial resistance has become an urgent threat to global public health. In this research, since photothermal therapy is a potential antibacterial strategy, which is less likely to cause resistance, a metal–organic framework-based chemo-photothermal combinational system was constructed. Zeolitic imidazolate frameworks-8 (ZIF-8), a porous carrier with unique features such as high loading and pH-sensitive degradation, was synthesized, and then encapsulated photothermal agent indocyanine green (ICG). First, ICG with improved stability in ZIF-8 (ZIF-8-ICG) can effectively produce heat in response to NIR laser irradiation for precise, rapid, and efficient photothermal bacterial ablation. Meanwhile, Zn2+ ions released from ZIF-8 can inhibit bacterial growth by increasing the permeability of bacterial cell membrane and further strengthen photothermal therapy efficacy by reducing the heat resistance of bacteria. Study showed that bacteria suffered from significant changes in morphology after treatment with ZIF-8-ICG under laser irradiation. The combinational chemo-hyperthermia therapy of ZIF-8-ICG could thoroughly ablate murine subcutaneous abscess induced by methicillin-resistant Staphylococcus aureus (MRSA), exhibiting a nearly 100% bactericidal ratio. Both in vitro and in vivo safety evaluation confirmed that ZIF-8-ICG was low toxic. Overall, our researches demonstrated that ZIF-8-ICG has great potential to be served as an alternative to antibiotics in combating multidrug-resistant bacterial pathogens.

scholarly journals Metal–Organic Framework/Graphene Quantum Dot Nanoparticles Used for Synergistic Chemo- and Photothermal Therapy

ACS Omega ◽  
2017 ◽  
Vol 2 (3) ◽  
pp. 1249-1258 ◽  
Author(s):  
Zhengfang Tian ◽  
Xianxian Yao ◽  
Kexin Ma ◽  
Xingxing Niu ◽  
Julia Grothe ◽  
...  
Keyword(s):  
Quantum Dot ◽  
Photothermal Therapy ◽  
Metal Organic Framework ◽  
Graphene Quantum Dot ◽  
Metal Organic ◽  
Organic Framework

Facile synthesis of polypyrrole@metal–organic framework core–shell nanocomposites for dual-mode imaging and synergistic chemo-photothermal therapy of cancer cells

2017 ◽  
Vol 5 (9) ◽  
pp. 1772-1778 ◽  
Author(s):  
Xiangjun Chen ◽  
Manjie Zhang ◽  
Shengnan Li ◽  
Lu Li ◽  
Lingyu Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Metal Organic Framework ◽  
Core Shell ◽  
Dual Mode ◽  
Facile Synthesis ◽  
Metal Organic ◽  
Facile Route

A facile route was developed to fabricate PPy@MOF for dual-mode magnetic resonance/photoacoustic imaging and synergistic chemo-photothermal therapy.

scholarly journals Core-Shell Upconversion Nanoparticle@Metal-Organic Framework Nanoprobes for Luminescent/Magnetic Dual-Mode Targeted Imaging

2015 ◽  
Vol 27 (27) ◽  
pp. 4075-4080 ◽  
Author(s):  
Yantao Li ◽  
Jinglong Tang ◽  
Liangcan He ◽  
Yong Liu ◽  
Yaling Liu ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Core Shell ◽  
Targeted Imaging ◽  
Dual Mode ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy

2020 ◽  
Vol Volume 15 ◽  
pp. 3235-3250 ◽  
Author(s):  
Haibin Guo ◽  
Yanqing Xia ◽  
Ke Feng ◽  
Xiaowei Qu ◽  
Cuilian Zhang ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Surface Engineering ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework
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