A fucoidan from sea cucumber Pearsonothuria graeffei with well-repeated structure alleviates gut microbiota dysbiosis and metabolic syndromes in HFD-fed mice

2018 ◽  
Vol 9 (10) ◽  
pp. 5371-5380 ◽  
Author(s):  
Shan Li ◽  
Junhui Li ◽  
Guizhu Mao ◽  
Tiantian Wu ◽  
Yaqin Hu ◽  
...  

A high-fat diet (HFD) has been a major contributor to increasing morbidity caused by metabolic syndromes.


2019 ◽  
Vol 71 ◽  
pp. 72-88 ◽  
Author(s):  
Zahra Safari ◽  
Magali Monnoye ◽  
Peter M. Abuja ◽  
Mahendra Mariadassou ◽  
Karl Kashofer ◽  
...  




2021 ◽  
Author(s):  
Dong Zhao ◽  
Jinhu Cao ◽  
Huiqin Jin ◽  
Yanke Shan ◽  
Jian Fang ◽  
...  

Abstract: Metabolic syndromes caused obesity has long been recognized as a risk of health. Celery and celery extracts have various medicinal properties, such as anti-diabetes, anti-inflammatory and blood glucose and...



Gut ◽  
2020 ◽  
Vol 69 (12) ◽  
pp. 2259.1-2259 ◽  
Author(s):  
Tianyu Liu ◽  
Bangmao Wang ◽  
Hailong Cao






2021 ◽  
Vol 12 ◽  
Author(s):  
Ying Shi ◽  
Ruixue Feng ◽  
Jieqi Mao ◽  
Shuangping Liu ◽  
Zhilei Zhou ◽  
...  

Hyperlipidemia is a chronic disorder that is difficult to cure and usually treated with long-term lipid-reducing drugs. Recent trends have led to the use of diet therapies or food-derived strategies in the treatment of such long-term diseases. The Chinese rice wine (huangjiu) contains a wide range of bioactive peptides that are produced during the multi-species fermentation process. To clarify the regulation effects of lipid metabolism and gut microbiota by huangjiu bioactive peptides, three huangjiu peptides were isolated, purified and characterized by hyper-filtration, macroporous resin, gel filtration separation and structural identification. Meanwhile, a mouse model of high-fat diet-induced hyperlipidemia was established to study the effects of huangjiu peptides on serum biomarker, hepatic metabolism and gut microbiota dysbiosis. Experimental results showed that huangjiu peptides T1 and T2 (HpT1, HpT2) treatment alleviated the increase in serum total cholesterol, triglyceride, low-density lipoprotein cholesterol levels and aberrant hepatic lipid accumulation in the high-fat diet-induced hyperlipidemia mice. Furthermore, HpT2 and HpT1 restored the α-diversity and structure of gut microbial community after hyperlipidemia-induced microbiota disturbance compared with simvastatin and HpT3. The administration of HpT2 and HpT1 regulated the microbiota-mediated gut ecology through alterations of characteristic taxa including Lactobacillus, Ileibacterium, Faecalibaculum and Alloprevotella by linear discriminant analysis effect size analysis. Collectively, our results offer new insights into the abilities of food-derived peptides on alleviation of high-fat diet-induced hyperlipidemia, hepatic steatosis and gut dysbiosis in mice.



2019 ◽  
Vol 10 (2) ◽  
pp. 1073-1084 ◽  
Author(s):  
Wenbin Zhou ◽  
Rui Guo ◽  
Weiling Guo ◽  
Jiali Hong ◽  
Lu Li ◽  
...  

Monascus yellow, red and orange pigments modulate specific gut microbial phylotypes and regulating mRNA expression involved in glucose, lipid and cholesterol metabolism.



2021 ◽  
Author(s):  
Yiping Zhang ◽  
Nannan Zhao ◽  
Longhe Yang ◽  
Zhuan Hong ◽  
Bing Cai ◽  
...  

Insoluble dietary fibers derived from Laminaria japonica attenuate high-fat diet-induced obesity associated with restoration of Akkermansia to the normal level.



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