scholarly journals Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides

MedChemComm ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 116-119 ◽  
Author(s):  
Fabrizio Olivito ◽  
Nicola Amodio ◽  
Maria Luisa Di Gioia ◽  
Monica Nardi ◽  
Manuela Oliverio ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Preliminary Evaluation ◽  
Natural Analogue ◽  
Anti Cancer ◽  
A549 Lung ◽  
Cancer Activity

In this work we synthesized and tested a series of unsaturated disulfides. Two compounds showed a promising anticancer activity in vitro on A549 lung cancer cells compared to the natural analogue.

scholarly journals Anti-cancer activity of biosynthesized silver nanoparticles using Avicennia marina against A549 lung cancer cells through ROS/mitochondrial damages

2020 ◽  
Vol 27 (11) ◽  
pp. 3018-3024 ◽  
Author(s):  
Shan Tian ◽  
Kandasamy Saravanan ◽  
Ramzi A. Mothana ◽  
Govindan Ramachandran ◽  
Govindan Rajivgandhi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Silver Nanoparticles ◽  
Cancer Cells ◽  
Avicennia Marina ◽  
Lung Cancer Cells ◽  
Anti Cancer ◽  
A549 Lung ◽  
Cancer Activity

scholarly journals Potent anti-cancer activity of Alnus nitida against lung cancer cells; in vitro and in vivo studies

2019 ◽  
Vol 110 ◽  
pp. 254-264 ◽  
Author(s):  
Moniba Sajid ◽  
Chao Yan ◽  
Dawei Li ◽  
Siva Bharath Merugu ◽  
Hema Negi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
In Vivo Studies ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Chloroquine increases the anti‑cancer activity of epirubicin in A549 lung cancer cells

2020 ◽  
Author(s):  
Ai‑Ling Liang ◽  
Jing Zhang ◽  
Shen‑Lin Du ◽  
Bin Zhang ◽  
Xuan Ma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Anti Cancer ◽  
A549 Lung ◽  
Cancer Activity

scholarly journals Erratum: Corrigendum: Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Seong-Hoon Kim ◽  
Hye Guk Ryu ◽  
Juhyun Lee ◽  
Joon Shin ◽  
Amaravadhi Harikishore ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Ursolic Acid ◽  
Lung Cancer Cells ◽  
Damage Repair ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Combined anticancer activity of osthole and cisplatin in NCI-H460 lung cancer cells in vitro

2013 ◽  
Vol 5 (3) ◽  
pp. 707-710 ◽  
Author(s):  
XIAO-MAN XU ◽  
YI ZHANG ◽  
DAN QU ◽  
HONG-BO LIU ◽  
XIU GU ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Lung Cancer Cells

scholarly journals Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy

2020 ◽  
Vol 11 ◽  
pp. 354-369
Author(s):  
Gayathri Kandasamy ◽  
Elena N Danilovtseva ◽  
Vadim V Annenkov ◽  
Uma Maheswari Krishnan
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Vascular Endothelial ◽  
Cytotoxic Effects ◽  
Lung Cancer Therapy ◽  
Interfering Rna ◽  
Endothelial Growth Factor ◽  
A549 Lung

The present work explores the ability of poly(1-vinylimidazole) (PVI) to complex small interfering RNA (siRNA) silencing vascular endothelial growth factor (VEGF) and the in vitro efficiency of the formed complexes in A549 lung cancer cells. The polyplex formed was found to exhibit 66% complexation efficiency. The complexation was confirmed by gel retardation assays, FTIR and thermal analysis. The blank PVI polymer was not toxic to cells. The polyplex was found to exhibit excellent internalization and escaped the endosome effectively. The polyplex was more effective than free siRNA in silencing VEGF in lung cancer cells. The silencing of VEGF was quantified using Western blot and was also reflected in the depletion of HIF-1α levels in the cells treated with the polyplex. VEGF silencing by the polyplex was found to augment the cytotoxic effects of the chemotherapeutic agent 5-fluorouracil. Microarray analysis of the mRNA isolated from cells treated with free siRNA and the polyplex reveal that the VEGF silencing by the polyplex also altered the expression levels of several other genes that have been connected to the proliferation and invasion of lung cancer cells. These results indicate that the PVI complexes can be an effective agent to counter lung cancer.

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