Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers

Metallomics ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 64-84 ◽  
Author(s):  
Monika Rana ◽  
Anuj Kumar Sharma
Keyword(s):  
Alzheimer’S Disease ◽  
Coordination Chemistry ◽  
Transition Metal ◽  
Metal Ions ◽  
Amyloid Β ◽  
Transition Metal Ions ◽  
Aβ Oligomers ◽  
Aβ Peptides ◽  
Soluble Aβ Oligomers ◽  
Cu And Zn

The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer's disease (AD).

Reactivity of Hydrated Monovalent First Row Transition Metal Ions [M(H2O)n]+, M = Cr, Mn, Fe, Co, Ni, Cu, and Zn, n < 50, Toward Acetonitrile

2015 ◽  
Vol 119 (22) ◽  
pp. 5566-5578 ◽  
Author(s):  
Ina Herber ◽  
Wai-Kit Tang ◽  
Ho-Yin Wong ◽  
Tim-Wai Lam ◽  
Chi-Kit Siu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions ◽  
Cu And Zn

Systematic Structural Coordination Chemistry of p-tert-Butyltetrathiacalix[4]arene: Further Complexes of Transition-Metal Ions

2010 ◽  
Vol 2010 (14) ◽  
pp. 2106-02126 ◽  
Author(s):  
Alexander Bilyk ◽  
John W. Dunlop ◽  
Rebecca O. Fuller ◽  
Annegret K. Hall ◽  
Jack M. Harrowfield ◽  
...  
Keyword(s):  
Coordination Chemistry ◽  
Transition Metal ◽  
Metal Ions ◽  
Transition Metal Ions

scholarly journals Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243041
Author(s):  
DaWon Kim ◽  
Jeong Hwa Lee ◽  
Hye Yun Kim ◽  
Jisu Shin ◽  
Kyeonghwan Kim ◽  
...  
Keyword(s):  
Mouse Model ◽  
Transgenic Mouse ◽  
Neurodegenerative Disorder ◽  
Amyloid Β ◽  
Transgenic Mouse Model ◽  
Aβ Oligomers ◽  
Aβ Peptides ◽  
Soluble Aβ Oligomers ◽  
The Brain

Alzheimer disease (AD) is a neurodegenerative disorder characterized by the aberrant production and accumulation of amyloid-β (Aβ) peptides in the brain. Accumulated Aβ in soluble oligomer and insoluble plaque forms are considered to be a pathological culprit and biomarker of the disorder. Here, we report a fluorescent universal Aβ-indicator YI-13, 5-(4-fluorobenzoyl)-7,8-dihydropyrrolo[1,2-b]isoquinolin-9(6H)-one, which detects Aβ monomers, dimers, and plaques. We synthesized a library of 26 fluorescence chemicals with the indolizine core and screen them through a series of in vitro tests utilizing Aβ as a target and YI-13 was selected as the final imaging candidate. YI-13 was found to stain and visualize insoluble Aβ plaques in the brain tissue, of a transgenic mouse model with five familial AD mutations (5XFAD), by a histochemical approach and to label soluble Aβ oligomers within brain lysates of the mouse model under a fluorescence plate reader. Among oligomers aggregated from monomers and synthetic dimers from chemically conjugated monomers, YI-13 preferred the dimeric Aβ.

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