Chiral separation and a molecular modeling study of eight azole antifungals on the cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase

2018 ◽  
Vol 42 (16) ◽  
pp. 13421-13429 ◽  
Author(s):  
Bolin Zhu ◽  
Fan Zhao ◽  
Jia Yu ◽  
Zhaokun Wang ◽  
Yongbo Song ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Molecular Modeling ◽  
Stationary Phase ◽  
Chiral Separation ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Normal Phase ◽  
Azole Antifungals ◽  
Phase Liquid

Four immobilized polysaccharide-based chiral stationary phases have been examined for their enantioselectivity on azole analytes using normal phase liquid chromatography.

Chiral Separation of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-di -hydropyrimidin- 2(1H)-thiones Enantiomers by HPLC on Chiralcel®OD-H

2020 ◽  
Vol 16 (3) ◽  
pp. 250-255
Author(s):  
Noura Kichou ◽  
Ismahan Rahou ◽  
Zaid M. Elamin ◽  
Khaled Sekkoum ◽  
Nasser Belboukhari ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Stationary Phase ◽  
Chiral Separation ◽  
Chiral Stationary Phase ◽  
Normal Phase ◽  
Good Resolution ◽  
Mode Structure ◽  
Structure Retention ◽  
Short Time

Objective: Ten racemic 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin- 2(1H)-thiones were separated by liquid chromatography on Chiralcel®OD-H column containing cellulose tris(3, 5-dimethylphenylcarbamate). Methods: The enantioseparation was carried out using Chiralcel®OD-H polysaccharide-type chiral stationary phase to resolve such enantiomers under normal-phase mode. Results: Complete separations of the 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin- 2(1H)-thiones derivatives with good resolution (RS= 1.04-2.80) were achieved within a short time (10-15 min). Conclusion: An optimal baseline separation (Rs> 1.5) was achieved using Chiralcel®OD-H under normal-phase mode. Structure-retention relationships have also been discussed.

Determination of methionine enantiomers by HPLC on the cyclofructan chiral stationary phase

2015 ◽  
Vol 7 (11) ◽  
pp. 4577-4582 ◽  
Author(s):  
Katarína Hroboňová ◽  
Jakub Moravčík ◽  
Jozef Lehotay ◽  
Daniel W. Armstrong
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Stationary Phase ◽  
High Performance ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Enantiomeric Separation

The enantiomeric separation of methionine by high performance liquid chromatography on various cyclofructan type chiral stationary phases in the polar-organic separation mode was studied.

scholarly journals The Separation of Cannabinoids on Sub-2 µm Immobilized Polysaccharide Chiral Stationary Phases

2021 ◽  
Vol 14 (12) ◽  
pp. 1250
Author(s):  
Takafumi Onishi ◽  
Weston J. Umstead
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Reversed Phase ◽  
Normal Phase ◽  
Elution Order ◽  
Testing Methods ◽  
Structural Isomers

The increased use and applicability of Cannabis and Cannabis-derived products has skyrocketed over the last 5 years. With more and more governing bodies moving toward medical and recreational legalization, the need for robust and reliable analytical testing methods is also growing. While many stationary phases and methods have been developed for this sort of analysis, chiral stationary phases (CSPs) are unique in this area; not only can they serve their traditional chiral separation role, but they can also be used to perform achiral separations. Given that mixtures of cannabinoids routinely contain enantiomers, diastereomers, and structural isomers, this offers an advantage over the strictly achiral-only analyses. This work presents the separation of a 10-cannabinoid mixture on several polysaccharide-based sub-2 µm CSPs with both normal-phase and reversed-phase ultra-high-performance liquid chromatography (UHPLC) conditions. Along with the separation of the mixture, appropriate single-peak identification was performed to determine the elution order and reported where applicable.

Chiral stationary phases consisting of π-conjugated polymers bearing glucose-linked biphenyl units: reversible switching of resolution abilities based on a coil-to-helix transition

2017 ◽  
Vol 8 (29) ◽  
pp. 4190-4198 ◽  
Author(s):  
Tomoyuki Ikai ◽  
Seiya Awata ◽  
Tomoya Kudo ◽  
Ryoma Ishidate ◽  
Katsuhiro Maeda ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Conjugated Polymers ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Chiral Stationary Phases

We have succeeded in developing a novel chiral stationary phase that can reversibly switch resolution abilities based on a coil-to-helix transition in a column.

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