scholarly journals The protosteryl and dammarenyl cation dichotomy in polycyclic triterpene biosynthesis revisited: has this ‘rule’ finally been broken?

2019 ◽  
Vol 36 (8) ◽  
pp. 1044-1052 ◽  
Author(s):  
Michael J. Stephenson ◽  
Robert A. Field ◽  
Anne Osbourn
Keyword(s):  
Triterpene Biosynthesis

A well-established dichotomy in the biogenesis of polycyclic triterpenes is outlined and contrasted with a recently reported novel pentacyclic scaffold.

scholarly journals Chemical Phenotypes of the hmg1 and hmg2 Mutants of Arabidopsis Demonstrate the In-planta Role of HMG-CoA Reductase in Triterpene Biosynthesis

2007 ◽  
Vol 55 (10) ◽  
pp. 1518-1521 ◽  
Author(s):  
Kiyoshi Ohyama ◽  
Masashi Suzuki ◽  
Kazuo Masuda ◽  
Shigeo Yoshida ◽  
Toshiya Muranaka
Keyword(s):  
In Planta ◽  
Hmg Coa Reductase ◽  
Coa Reductase ◽  
Triterpene Biosynthesis

N-terminal sequences affect expression of triterpene biosynthesis enzymes in Chlamydomonas chloroplasts

2019 ◽  
Vol 44 ◽  
pp. 101662
Author(s):  
Shih-Chi Hsu ◽  
Daniel R. Browne ◽  
Mehmet Tatli ◽  
Timothy P. Devarenne ◽  
David B. Stern
Keyword(s):  
Affect Expression ◽  
Triterpene Biosynthesis

scholarly journals Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii

2011 ◽  
Vol 108 (30) ◽  
pp. 12260-12265 ◽  
Author(s):  
T. D. Niehaus ◽  
S. Okada ◽  
T. P. Devarenne ◽  
D. S. Watt ◽  
V. Sviripa ◽  
...  
Keyword(s):  
Botryococcus Braunii ◽  
Triterpene Biosynthesis

scholarly journals Polyploidy underlies co-option and diversification of biosynthetic triterpene pathways in the apple tribe

2021 ◽  
Vol 118 (20) ◽  
pp. e2101767118
Author(s):  
Wenbing Su ◽  
Yi Jing ◽  
Shoukai Lin ◽  
Zhen Yue ◽  
Xianghui Yang ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Genome Duplication ◽  
Developmental Stages ◽  
Plant Evolution ◽  
Metabolic Diversity ◽  
Medicinal Properties ◽  
And Function ◽  
Genomic Basis ◽  
Triterpene Biosynthesis ◽  
Chromosome Level

Whole-genome duplication (WGD) plays important roles in plant evolution and function, yet little is known about how WGD underlies metabolic diversification of natural products that bear significant medicinal properties, especially in nonmodel trees. Here, we reveal how WGD laid the foundation for co-option and differentiation of medicinally important ursane triterpene pathway duplicates, generating distinct chemotypes between species and between developmental stages in the apple tribe. After generating chromosome-level assemblies of a widely cultivated loquat variety and Gillenia trifoliata, we define differentially evolved, duplicated gene pathways and date the WGD in the apple tribe at 13.5 to 27.1 Mya, much more recent than previously thought. We then functionally characterize contrasting metabolic pathways responsible for major triterpene biosynthesis in G. trifoliata and loquat, which pre- and postdate the Maleae WGD, respectively. Our work mechanistically details the metabolic diversity that arose post-WGD and provides insights into the genomic basis of medicinal properties of loquat, which has been used in both traditional and modern medicines.

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