scholarly journals Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

2019 ◽  
Vol 17 (6) ◽  
pp. 1480-1486 ◽  
Author(s):  
Phillip T. Lowe ◽  
Sergio Dall'Angelo ◽  
Ian N. Fleming ◽  
Monica Piras ◽  
Matteo Zanda ◽  
...  

FDA-PEG-GUL was enzymatically synthesised using the fluorinase in 18F-radiolabelled form and shown to efficiently bind the prostate-specific antigen (PSMA) which is upregulated in prostate cancer cells.

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