scholarly journals Direct β-selectivity of α,β-unsaturated γ-butyrolactam for asymmetric conjugate additions in an organocatalytic manner

RSC Advances ◽  
2018 ◽  
Vol 8 (51) ◽  
pp. 28874-28878
Author(s):  
Yuan Zhong ◽  
Sihua Hong ◽  
Zhengjun Cai ◽  
Shixiong Ma ◽  
Xianxing Jiang
Keyword(s):  
Conjugate Additions ◽  
Asymmetric Addition ◽  
Imino Esters

The asymmetric addition of γ-butyrolactam with cyclic imino esters catalyzed by (DHQD)2AQN has been developed, which provides an access to β-position functionalized pyrrolidin-2-one derivatives in high levels yield and enantioselectivity.

Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules

2016 ◽  
Vol 21 (3) ◽  
pp. 190-217 ◽  
Author(s):  
Paola Vitale ◽  
Vito Capriati ◽  
Saverio Florio ◽  
Filippo Perna ◽  
Antonio Salomone
Keyword(s):  
Conjugate Additions ◽  
Complex Molecules

Electroreductive Intramolecular Coupling of Aromatic β- and γ-Imino Esters:  A New Synthetic Method forN-Alkoxycarbonyl-2-aryl-3-ones andcis-2-Aryl-3-ols of Pyrrolidines and Piperidines

2004 ◽  
Vol 69 (22) ◽  
pp. 7710-7719 ◽  
Author(s):  
Naoki Kise ◽  
Kengo Ohya ◽  
Kie Arimoto ◽  
Yutaka Yamashita ◽  
Yuuki Hirano ◽  
...  
Keyword(s):  
Synthetic Method ◽  
Imino Esters

Zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source

2021 ◽  
Vol 19 (16) ◽  
pp. 3601-3610
Author(s):  
Guoli Shen ◽  
Haojie Liu ◽  
Jingchao Chen ◽  
Zhenxiu He ◽  
Yongyun Zhou ◽  
...  
Keyword(s):  
Zinc Salt ◽  
Imino Esters

The zinc salt-catalyzed reduction of α-aryl imino esters, diketones and phenylacetylenes with water as hydrogen source and zinc as reductant was successfully conducted.

Synthetic Strategies to Access Heteroatomic Spirocentres Embedded in Natural Products

Synthesis ◽  
2021 ◽  
Author(s):  
Michael P. Badart ◽  
Bill C. Hawkins
Keyword(s):  
Natural Products ◽  
Heterocyclic Compound ◽  
Chemical Space ◽  
Three Dimensional ◽  
Coupling Reactions ◽  
Conjugate Additions ◽  
Biological Targets ◽  
Compound Libraries ◽  
The Common ◽  
Significant Attention

AbstractThe spirocyclic motif is abundant in natural products and provides an ideal three-dimensional template to interact with biological targets. With significant attention historically expended on the synthesis of flat-heterocyclic compound libraries, methods to access the less-explored three-dimensional medicinal-chemical space will continue to increase in demand. Herein, we highlight by reaction class the common strategies used to construct the spirocyclic centres embedded in a series of well-studied natural products.1 Introduction2 Cycloadditions3 Palladium-Catalysed Coupling Reactions4 Conjugate Additions5 Imines, Aminals, and Hemiaminal Ethers6 Mannich-Type Reactions7 Oxidative Dearomatisation8 Alkylation9 Organometallic Additions10 Conclusions

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