scholarly journals A non-sacrificial method for the quantification of poly(ethylene glycol) grafting density on gold nanoparticles for applications in nanomedicine

2019 ◽  
Vol 10 (7) ◽  
pp. 2067-2074 ◽  
Author(s):  
Jun Lu ◽  
Yao Xue ◽  
Rui Shi ◽  
Jing Kang ◽  
Chao-Yang Zhao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Splitting Algorithm ◽  
H Nmr ◽  
Grafting Density ◽  
Poly Ethylene

A multi-Lorentzian-splitting algorithm is used to distinguish the 1H NMR signal of free PEG from that of grafted PEG, therefore allowing monitoring of the grafting process in situ.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

Transdermal delivery of poly(ethylene glycol)-co-oleylamine modified gold nanoparticles: Effect of size and shape

2019 ◽  
Vol 224 ◽  
pp. 22-28 ◽  
Author(s):  
Pa Fan Hsiao ◽  
Hsieh-Chih Tsai ◽  
Sydney Peng ◽  
Adhimoorthy Prasannan ◽  
Ting-Cheng Tang ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Ethylene Glycol ◽  
Transdermal Delivery ◽  
Poly Ethylene Glycol ◽  
Size And Shape ◽  
Poly Ethylene

scholarly journals Tailoring Nanocellulose–Cellulose Triacetate Interfaces by Varying the Surface Grafting Density of Poly(ethylene glycol)

ACS Omega ◽  
2018 ◽  
Vol 3 (9) ◽  
pp. 11883-11889 ◽  
Author(s):  
Hiroto Soeta ◽  
Giada Lo Re ◽  
Akihiro Masuda ◽  
Shuji Fujisawa ◽  
Tsuguyuki Saito ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Cellulose Triacetate ◽  
Surface Grafting ◽  
Poly Ethylene Glycol ◽  
Grafting Density ◽  
Poly Ethylene
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