Laser trapping/confocal Raman spectroscopic characterization of PLGA-PEG nanoparticles

Soft Matter ◽  
2018 ◽  
Vol 14 (40) ◽  
pp. 8090-8094 ◽  
Author(s):  
Jie Yang ◽  
Ruo-Nan Zhang ◽  
Dong-Jie Liu ◽  
Xu Zhou ◽  
Tatsuya Shoji ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Spectroscopic Characterization ◽  
Plga Nanoparticles ◽  
Laser Trapping ◽  
Poly Ethylene Glycol ◽  
Chemical Methods ◽  
Raman Spectroscopic ◽  
Confocal Raman ◽  
Poly Ethylene

We have immobilized poly(ethylene glycol) (PEG) on the surfaces of poly(lactic-co-glycolic acid) (PLGA) nanoparticles by two different chemical methods, i.e., SOCl2 halogenate-alcoholysis and DCC dehydration. The PEG-immobilized PLGA nanoparticles were precisely characterized by the laser trapping/confocal Raman spectroscope.

Biodegradable PLGA nanoparticles loaded with hydrophobic drugs: confocal Raman microspectroscopic characterization

2015 ◽  
Vol 3 (18) ◽  
pp. 3677-3680 ◽  
Author(s):  
Hu Yan ◽  
Yi-Fan Hou ◽  
Peng-Fei Niu ◽  
Ke Zhang ◽  
Tatsuya Shoji ◽  
...  
Keyword(s):  
Plga Nanoparticles ◽  
Spectroscopic Technique ◽  
Laser Trapping ◽  
Hydrophobic Drugs ◽  
Raman Spectroscopic ◽  
Confocal Raman ◽  
Individual Nanoparticles ◽  
First Time

PLGA nanoparticles with bicyclol and Br-NBP were for the first time successfully characterized by a laser trapping/confocal Raman spectroscopic technique only using individual nanoparticles.

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