Enzymatic synthesis of PEG–poly(amine-co-thioether esters) as highly efficient pH and ROS dual-responsive nanocarriers for anticancer drug delivery

2019 ◽  
Vol 7 (4) ◽  
pp. 651-664 ◽  
Author(s):  
Yi-hong Gong ◽  
Man Shu ◽  
Jian-hua Xie ◽  
Chao Zhang ◽  
Zhong Cao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Enzymatic Synthesis ◽  
Anticancer Drug Delivery ◽  
Highly Efficient ◽  
Dual Responsive ◽  
Synthesized Materials ◽  
Drug Nanocarriers ◽  
Dual Responsibilities

Novel multifunctional drug nanocarriers with pH and ROS dual-responsibilities were developed using enzymatically synthesized materials.

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

2020 ◽  
Vol 20 (11) ◽  
pp. 6959-6967
Author(s):  
Rimesh Augustine ◽  
Dae-Kyoung Kim ◽  
Ho An Kim ◽  
Jae Ho Kim ◽  
Il Kim
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Loading ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Micellar Aggregates ◽  
Reversible Addition ◽  
Hydrogen Carbonate ◽  
Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

Amphiphilic drug–drug assembly via dual-responsive linkages for small-molecule anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66420-66430 ◽  
Author(s):  
Tian Zhong ◽  
Ran Huang ◽  
Lianjiang Tan
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Disulfide Bonds ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Amphiphilic Drug

Amphiphilic drug–drug assembly nanoparticles based on dual-responsive H-bonding-instructed disulfide bonds can release irinotecan and doxorubicin simultaneously in cancer cells for anticancer purposes.

scholarly journals Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery

2014 ◽  
Vol 50 (95) ◽  
pp. 15105-15108 ◽  
Author(s):  
Yue Lu ◽  
Ran Mo ◽  
Wanyi Tai ◽  
Wujin Sun ◽  
Dennis B. Pacardo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

scholarly journals Correction: FRET-based intracellular investigation of nanoprodrugs toward highly efficient anticancer drug delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (42) ◽  
pp. 21951-21951
Author(s):  
Farsai Taemaitree ◽  
Beatrice Fortuni ◽  
Yoshitaka Koseki ◽  
Eduard Fron ◽  
Susana Rocha ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Highly Efficient ◽  
Intracellular Investigation

Correction for ‘FRET-based intracellular investigation of nanoprodrugs toward highly efficient anticancer drug delivery’ by Farsai Taemaitree et al., Nanoscale, 2020, 12, 16710–16715, DOI: 10.1039/D0NR04910G.

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