pH and redox dual-responsive biodegradable polymeric micelles with high drug loading for effective anticancer drug delivery

A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

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Poly(N-isopropylacrylamide)-b-Poly(L-lysine)-b-Poly(L-histidine) Triblock Amphiphilic Copolymer Nanomicelles for Dual-Responsive Anticancer Drug Delivery

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.18822 ◽

2020 ◽

Vol 20 (11) ◽

pp. 6959-6967

Author(s):

Rimesh Augustine ◽

Dae-Kyoung Kim ◽

Ho An Kim ◽

Jae Ho Kim ◽

Il Kim

Keyword(s):

Drug Delivery ◽

Anticancer Drug ◽

Drug Loading ◽

Anticancer Drug Delivery ◽

Dual Responsive ◽

Micellar Aggregates ◽

Reversible Addition ◽

Hydrogen Carbonate ◽

Copolymer Micelle

A series of ABC triblock poly(N-isopropylacrylamide)75-block-poly(L-lysine)35-block-poly(L-histidine)n (p(NIPAM)75-b-p(Lys)35-b-p(His)N) (N = 35,50,75,100) copolymer bio-conjugates were prepared by combining reversible addition-fragmentation chain transfer polymerization and fast ring-opening polymerization of N-carboxyanhydride a-amino acid using 1,3-dicyclohexylimidazolium hydrogen carbonate as a catalyst. All the resulting triblock copolymers self-assembled into spherical micellar aggregates in aqueous solution, irrespective of the chain length of the histidine block. The micellar aggregates encapsulated the anticancer drug doxorubicin (Dox) and exhibited high drug loading efficiency. Temperature and pH stimuli were applied to investigate the controlled release of Dox. The non-cytotoxic nature of the polymers was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cellular uptake of the Dox-loaded micelles revealed that the micelles successfully release Dox in cancer cells in response to pH- and temperature-induced morphological change. In-vitro studies further confirmed that the Dox-loaded triblock copolymer micelle is an excellent platform for drug delivery.

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Superparamagnetic yolk–shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

RSC Advances ◽

10.1039/c6ra21492d ◽

2016 ◽

Vol 6 (105) ◽

pp. 103399-103411 ◽

Cited By ~ 10

Author(s):

Tuan-Wei Sun ◽

Ying-Jie Zhu ◽

Feng Chen ◽

Chao Qi ◽

Bing-Qiang Lu ◽

...

Keyword(s):

Drug Delivery ◽

Iron Oxide ◽

High Performance ◽

Drug Loading ◽

Magnesium Silicate ◽

Loading Capacity ◽

Ph Responsive ◽

High Drug ◽

Anticancer Drug Delivery ◽

High Drug Loading

The as-prepared yolk–shell porous nanospheres of SPIO@MS exhibit a high drug loading capacity, and a sustained and pH-responsive drug release behaviour.

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Preparation of Doxorubicin-Loaded Amphiphilic Poly(D,L-Lactide-Co-Glycolide)-b-Poly(N-Acryloylmorpholine) AB2 Miktoarm Star Block Copolymers for Anticancer Drug Delivery

Materials ◽

10.3390/ma13173713 ◽

2020 ◽

Vol 13 (17) ◽

pp. 3713

Author(s):

Kalyan Ramesh ◽

Avnish Kumar Mishra ◽

Jin Kon Kim ◽

Yeon Tae Jeong ◽

Yeong-Soon Gal ◽

...

Keyword(s):

Drug Delivery ◽

Block Copolymers ◽

Anticancer Drug ◽

Polymeric Micelles ◽

Drug Loading ◽

Gel Permeation Chromatography ◽

Critical Micellar Concentration ◽

Anticancer Drug Delivery ◽

Miktoarm Star ◽

Star Block Copolymers

Owing to their unique topology and physical properties, micelles based on miktoarm amphiphilic star block copolymers play an important role in the biomedical field for drug delivery. Herein, we developed a series of AB2-type poly(D,L-lactide-co-glycolide)-b-poly(N-acryloyl morpholine) (PLGA-b-PNAM2) miktoarm star block copolymers by reversible addition–fragmentation chain–transfer polymerization and ring-opening copolymerization. The resulting miktoarm star polymers were investigated by 1H NMR spectroscopy and gel permeation chromatography. The critical micellar concentration value of the micelles increases with an increase in PNAM block length. As revealed by transmission electron microscopy and dynamic light scattering, the amphiphilic miktoarm star block copolymers can self-assemble to form spherical micellar aggregates in water. The anticancer drug doxorubicin (DOX) was encapsulated by polymeric micelles; the drug-loading efficiency and drug-loading content of the DOX-loaded micelles were 81.7% and 9.1%, respectively. Acidic environments triggered the dissociation of the polymeric micelles, which led to the more release of DOX in pH 6.4 than pH 7.4. The amphiphilic PLGA-b-PNAM2 miktoarm star block copolymers may have broad application as nanocarriers for controlled drug delivery.

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Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery

Molecules ◽

10.3390/molecules27010281 ◽

2022 ◽

Vol 27 (1) ◽

pp. 281

Author(s):

Li Li ◽

Dongyu Lei ◽

Jiaojiao Zhang ◽

Lu Xu ◽

Jiashan Li ◽

...

Keyword(s):

Drug Delivery ◽

Disulfide Bonds ◽

Intelligent System ◽

Click Reaction ◽

Drug Loading ◽

Loading Capacity ◽

Triggered Release ◽

High Drug ◽

Dual Responsive ◽

High Drug Loading

Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed and synthesized by conjugates of glutamic acid-cysteine dendrimer with alginate (Glu-Cys-SA) through click reaction, and then cross-linked with polyethylene glycol (PEG) through hydrogen bonds to form a 3D-net structure. The hydrogel, self-assembled by the inner disulfide bonds of the dendrimer, is designed to respond to the GSH heterogeneity in tumors, with a remarkably high drug loading capacity. The Dox-loaded Glu-Cys-SA hydrogel showed controlled drug release behavior, significantly with a release rate of over 76% in response to GSH. The cytotoxicity investigation indicated that the prepared DOX-loaded hydrogel exhibited comparable anti-tumor activity against HepG-2 cells with positive control. These biocompatible hydrogels are expected to be well-designed GSH and pH dual-sensitive conjugates or polymers for efficient anticancer drug delivery.

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