The binding mode of vilazodone in the human serotonin transporter elucidated by ligand docking and molecular dynamics simulations

2020 ◽  
Vol 22 (9) ◽  
pp. 5132-5144 ◽  
Author(s):  
Yang Zhang ◽  
Guoxun Zheng ◽  
Tingting Fu ◽  
Jiajun Hong ◽  
Fengcheng Li ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Binding Mode ◽  
Ligand Docking ◽  
Action Mechanism ◽  
Major Depressive ◽  
Serotonin Reuptake Transporter ◽  
Dynamics Simulations

Vilazodone is a novel antidepressant for the treatment of major depressive disorder with the action mechanism of inhibiting the human serotonin reuptake transporter (hSERT), not only occupying the S1 binding site, but also extending to the S2 site.

scholarly journals Serotonin transporter binding as a possible predictor of one-year remission in major depressive disorder

2008 ◽  
Vol 42 (14) ◽  
pp. 1137-1144 ◽  
Author(s):  
Jeffrey M. Miller ◽  
Maria A. Oquendo ◽  
R. Todd Ogden ◽  
J. John Mann ◽  
Ramin V. Parsey
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Major Depressive ◽  
One Year

scholarly journals Positron Emission Tomography Quantification of Serotonin Transporter in Suicide Attempters with Major Depressive Disorder

2013 ◽  
Vol 74 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Jeffrey M. Miller ◽  
Natalie Hesselgrave ◽  
R. Todd Ogden ◽  
Gregory M. Sullivan ◽  
Maria A. Oquendo ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Emission Tomography ◽  
Major Depressive ◽  
Suicide Attempters ◽  
Positron Emission

Revealing vilazodone's binding mechanism underlying its partial agonism to the 5-HT1A receptor in the treatment of major depressive disorder

2017 ◽  
Vol 19 (42) ◽  
pp. 28885-28896 ◽  
Author(s):  
Guoxun Zheng ◽  
Weiwei Xue ◽  
Fengyuan Yang ◽  
Yang Zhang ◽  
Yuzong Chen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Computational Methods ◽  
Binding Mode ◽  
Binding Mechanism ◽  
Major Depressive ◽  
Partial Agonism

The binding mechanism of vilazodone to 5-HT1A receptor was revealed via integrated computational methods. The identified binding mode will provide valuable information for medicinal chemists in designing and discovering novel SPARIs for MDD treatment.

Computational identification of the binding mechanism of a triple reuptake inhibitor amitifadine for the treatment of major depressive disorder

2018 ◽  
Vol 20 (9) ◽  
pp. 6606-6616 ◽  
Author(s):  
Weiwei Xue ◽  
Panpan Wang ◽  
Gao Tu ◽  
Fengyuan Yang ◽  
Guoxun Zheng ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Reuptake Inhibitor ◽  
Binding Mode ◽  
Binding Mechanism ◽  
Major Depressive ◽  
Computational Identification ◽  
Key Residues

A shared binding mode involving eleven key residues at the S1 site of MATs for the binding of amitifadine is identified.

S84. PET Quantification of Serotonin Transporter Binding in Major Depressive Disorder

2019 ◽  
Vol 85 (10) ◽  
pp. S329
Author(s):  
Jeffrey Miller ◽  
Patrick Hurley ◽  
Francesca Zanderigo ◽  
Harry Rubin-Falcone ◽  
R. Todd Ogden ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Major Depressive ◽  
Pet Quantification

Role of the serotonin transporter gene locus in the response to SSRI treatment of major depressive disorder in late life

2015 ◽  
Vol 29 (5) ◽  
pp. 623-633 ◽  
Author(s):  
Davide Seripa ◽  
Andrea Pilotto ◽  
Giulia Paroni ◽  
Andrea Fontana ◽  
Grazia D’Onofrio ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Gene Locus ◽  
Late Life ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Major Depressive ◽  
Ssri Treatment

Social Adversity, the Serotonin Transporter (5-HTTLPR) Polymorphism and Major Depressive Disorder

2006 ◽  
Vol 59 (3) ◽  
pp. 224-229 ◽  
Author(s):  
Paul G. Surtees ◽  
Nicholas W.J. Wainwright ◽  
Saffron A.G. Willis-Owen ◽  
Robert Luben ◽  
Nicholas E. Day ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serotonin Transporter ◽  
Major Depressive ◽  
Social Adversity
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