Biological control of S-nitrosothiol reactivity: potential role of sigma-hole interactions

2020 ◽  
Vol 22 (12) ◽  
pp. 6595-6605
Author(s):  
Niloufar Hendinejad ◽  
Qadir K. Timerghazin

S-Nitrosothiols, ubiquitous biological derivatives of nitric oxide, can engage in σ-hole/bonding with Lewis bases, which, in combination with hydrogen bonding with Lewis acids, could be the basis of enzymatic control of S-nitrosothiol reactions.

1993 ◽  
Vol 125 (5) ◽  
pp. 967-969 ◽  
Author(s):  
David R. Clements ◽  
Rudolf Harmsen

Effective management of the interactions within the mite community is critical to biological control of economically damaging phytophagous mites such as Panonychus ulmi Koch (Tetranychidae) (Clements and Harmsen 1990). Although much is known about the potential role of phytoseiid mites in controlling P. ulmi (Dover et al. 1979), mites from at least seven other families may be present in apple orchards (Thistlewood 1991). Stigmaeid mites are predators which may play a beneficial role in biological control in conjunction with phytoseiids (Clements and Harmsen 1992). Eriophyid mites are phytophagous but seldom cause economic damage, and may compete with tetranychids and provide alternative food for predators of tetranychids (Croft and Hoying 1977).


2020 ◽  
Vol 22 (1) ◽  
pp. 72-79
Author(s):  
Alexandra Lee ◽  
◽  
Warwick Butt ◽  
◽  
◽  
...  

Inhaled nitric oxide has been used for 30 years to improve oxygenation and decrease pulmonary vascular resistance. In the past 15 years, there has been increased understanding of the role of endogenous nitric oxide on cell surface receptors, mitochondria, and intracellular processes involving calcium and superoxide radicals. This has led to several animal and human experiments revealing a potential role for administered nitric oxide or nitric oxide donors in patients with systemic inflammatory response syndrome or ischaemia–reperfusion injury, and in patients for whom exposure of blood to artificial surfaces has occurred.


2005 ◽  
Vol 26 (7) ◽  
pp. 585-597 ◽  
Author(s):  
Salih Ozgocmen ◽  
Huseyin Ozyurt ◽  
Sadik Sogut ◽  
Omer Akyol

Endothelium ◽  
1999 ◽  
Vol 7 (1) ◽  
pp. 1-9 ◽  
Author(s):  
F. H. Mumtaz ◽  
M. A. Khan ◽  
M. E. Sullivan ◽  
C. S. Thompson ◽  
D. P. Mikhailidis ◽  
...  

2016 ◽  
Vol 21 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Huzefa Vahora ◽  
Munawwar Ali Khan ◽  
Usama Alalami ◽  
Arif Hussain

1998 ◽  
Vol 85 (3) ◽  
pp. 830-834 ◽  
Author(s):  
Shubha Shastry ◽  
Niki M. Dietz ◽  
John R. Halliwill ◽  
Ann S. Reed ◽  
Michael J. Joyner

We sought to examine further the potential role of nitric oxide (NO) in the neurally mediated cutaneous vasodilation in nonacral skin during body heating in humans. Six subjects were heated with a water-perfused suit while cutaneous blood flow was measured by using laser-Doppler flowmeters placed on both forearms. The NO synthase inhibitor N G-monomethyl-l-arginine (l-NMMA) was given selectively to one forearm via a brachial artery catheter after marked cutaneous vasodilation had been established. During body heating, oral temperature increased by 1.1 ± 0.1°C while heart rate increased by 30 ± 6 beats/min. Mean arterial pressure stayed constant at 84 ± 2 mmHg. In the experimental forearm, cutaneous vascular conductance (CVC; laser-Doppler) decreased to 86 ± 5% of the peak response to heating ( P < 0.05 vs. pre-l-NMMA values) afterl-NMMA infusion. In some subjects, l-NMMA caused CVC to fall by ∼30%; in others, it had little impact on the cutaneous circulation. CVC in the control arm showed a similar increase with heating, then stayed constant whilel-NMMA was given to the contralateral side. These results demonstrate that NO contributes modestly, but not consistently, to cutaneous vasodilation during body heating in humans. They also indicate that NO is not the only factor responsible for the dilation.


2009 ◽  
Vol 11 (39) ◽  
pp. 8790 ◽  
Author(s):  
Koichi Fumino ◽  
Alexander Wulf ◽  
Ralf Ludwig

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