Isomeric Ir(iii) complexes for tracking mitochondrial pH fluctuations and inducing mitochondrial dysfunction during photodynamic therapy

Haijie Chen; Chen Ge; Huiqun Cao; Xuepeng Zhang; Ling Zhang; Linhai Jiang; Pingyu Zhang; Qianling Zhang

doi:10.1039/c9dt03453f

Isomeric Ir(iii) complexes for tracking mitochondrial pH fluctuations and inducing mitochondrial dysfunction during photodynamic therapy

Dalton Transactions ◽

10.1039/c9dt03453f ◽

2019 ◽

Vol 48 (46) ◽

pp. 17200-17209 ◽

Cited By ~ 4

Author(s):

Haijie Chen ◽

Chen Ge ◽

Huiqun Cao ◽

Xuepeng Zhang ◽

Ling Zhang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Mitochondrial Dysfunction ◽

Ph Response ◽

Ph Fluctuations

Two pairs of isomeric phosphorescent Ir(iii) complexes that show mitochondrial pH-response and induce mitochondrial dysfunction during photodynamic therapy.

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Reversing Multidrug Resistance by Inducing Mitochondrial Dysfunction for Enhanced Chemo-Photodynamic Therapy in Tumor

ACS Applied Materials & Interfaces ◽

10.1021/acsami.1c12725 ◽

2021 ◽

Vol 13 (38) ◽

pp. 45259-45268

Author(s):

Chao Shi ◽

Haiqiao Huang ◽

Xiao Zhou ◽

Zhen Zhang ◽

He Ma ◽

...

Keyword(s):

Photodynamic Therapy ◽

Multidrug Resistance ◽

Mitochondrial Dysfunction

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A Cancer-Recognizing Polymeric Photosensitizer Based on the Tumor Extracellular pH Response of Conjugated Polymers for Targeted Cancer Photodynamic Therapy

Macromolecular Bioscience ◽

10.1002/mabi.201400361 ◽

2014 ◽

Vol 14 (12) ◽

pp. 1688-1695 ◽

Cited By ~ 16

Author(s):

Songhee Jeong ◽

Wooram Park ◽

Chung-Sung Lee ◽

Kun Na

Keyword(s):

Photodynamic Therapy ◽

Conjugated Polymers ◽

Extracellular Ph ◽

Ph Response

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Reorganization of cytoskeleton induced by 5-aminolevulinic acid-mediated photodynamic therapy and its correlation with mitochondrial dysfunction

Lasers in Surgery and Medicine ◽

10.1002/lsm.20179 ◽

2005 ◽

Vol 36 (5) ◽

pp. 398-408 ◽

Cited By ~ 37

Author(s):

Jui-Chang Tsai ◽

Chia-Lun Wu ◽

Hsiung-Fei Chien ◽

Chin-Tin Chen

Keyword(s):

Photodynamic Therapy ◽

Mitochondrial Dysfunction ◽

Aminolevulinic Acid

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Apoptosis Induced by 2-Aryl Benzothiazoles-Mediated Photodynamic Therapy in Melanomas via Mitochondrial Dysfunction

Chemical Research in Toxicology ◽

10.1021/tx500080w ◽

2014 ◽

Vol 27 (7) ◽

pp. 1187-1198 ◽

Cited By ~ 10

Author(s):

Yin-Kai Chen ◽

Gopal Chandru Senadi ◽

Chih-Hung Lee ◽

Yi-Min Tsai ◽

Yan-Ren Chen ◽

...

Keyword(s):

Photodynamic Therapy ◽

Mitochondrial Dysfunction

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Apoptosis induced by methylene-blue-mediated photodynamic therapy in melanomas and the involvement of mitochondrial dysfunction revealed by proteomics

Cancer Science ◽

10.1111/j.1349-7006.2008.00910.x ◽

2008 ◽

Cited By ~ 12

Author(s):

Yongjun Chen ◽

Wei Zheng ◽

Yingqian Li ◽

Jieying Zhong ◽

Jianguo Ji ◽

...

Keyword(s):

Methylene Blue ◽

Photodynamic Therapy ◽

Mitochondrial Dysfunction

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Photodynamic Therapy

10.1039/9781847551658 ◽

2003 ◽

Cited By ~ 29

Keyword(s):

Photodynamic Therapy

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Construction of a near-infrared responsive upconversion nanoplatform against hypoxic tumors via NO-enhanced photodynamic therapy

Nanoscale ◽

10.1039/c9nr10453d ◽

2020 ◽

Vol 12 (14) ◽

pp. 7875-7887 ◽

Cited By ~ 2

Author(s):

Ying Lan ◽

Xiaohui Zhu ◽

Ming Tang ◽

Yihan Wu ◽

Jing Zhang ◽

...

Keyword(s):

Photodynamic Therapy ◽

Near Infrared ◽

Upconversion Nanoparticles

A near-infrared (NIR) activated theranostic nanoplatform based on upconversion nanoparticles (UCNPs) is developed in order to overcome the hypoxia-associated resistance in photodynamic therapy by photo-release of NO upon NIR illumination.

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Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

Polymer Chemistry ◽

10.1039/c9py01391a ◽

2019 ◽

Vol 10 (45) ◽

pp. 6116-6121 ◽

Cited By ~ 3

Author(s):

Tan Ji ◽

Lei Xia ◽

Wei Zheng ◽

Guang-Qiang Yin ◽

Tao Yue ◽

...

Keyword(s):

Photodynamic Therapy ◽

Self Assembly ◽

Star Polymers ◽

New Family ◽

Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

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A nitroreductase-activatable near-infrared theranostic photosensitizer for photodynamic therapy under mild hypoxia

Chemical Communications ◽

10.1039/d0cc02019b ◽

2020 ◽

Vol 56 (43) ◽

pp. 5819-5822

Author(s):

Jing Zheng ◽

Yongzhuo Liu ◽

Fengling Song ◽

Long Jiao ◽

Yingnan Wu ◽

...

Keyword(s):

Photodynamic Therapy ◽

Triplet State ◽

Near Infrared ◽

Mild Hypoxia

In this study, a near-infrared (NIR) theranostic photosensitizer was developed based on a heptamethine aminocyanine dye with a long-lived triplet state.

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