scholarly journals Systems biology approach to elucidation of contaminant biodegradation in complex samples – integration of high-resolution analytical and molecular tools

2019 ◽  
Vol 218 ◽  
pp. 481-504 ◽  
Author(s):  
Caroline Gauchotte-Lindsay ◽  
Thomas J. Aspray ◽  
Mara Knapp ◽  
Umer Z. Ijaz
Keyword(s):  
Systems Biology ◽  
High Resolution ◽  
Microbial Communities ◽  
Contaminated Soils ◽  
Rational Design ◽  
Data Driven ◽  
Molecular Tools ◽  
Complex Samples ◽  
Driven Systems

We present here a data-driven systems biology framework for the rational design of biotechnological solutions for contaminated environments with the aim of understanding the interactions and mechanisms underpinning the role of microbial communities in the biodegradation of contaminated soils.

scholarly journals Mobilizing Media Studies in an Age of Datafication

2020 ◽  
Vol 21 (6) ◽  
pp. 568-573 ◽  
Author(s):  
Lina Dencik
Keyword(s):  
Media Studies ◽  
Lived Experiences ◽  
Social Practices ◽  
Data Driven ◽  
Driven Systems ◽  
Data Practices

We are at a pivotal moment for understanding and deciding what is actually at stake with datafication. In this contribution, I argue for the increasingly important and politicized role of media scholarship to privilege lived experiences and situated practices as a counter to the active neutralization of data-driven systems and their implications. In particular, I argue for the relevance of media studies to emphasize the uses to which technology is put and explore how data practices relate to other social practices and historical contexts as a way to broaden the parameters of response, moving data politics beyond the confines of the technology itself, and contending instead with the premise and terms of the debate.

Combining integrated systems-biology approaches with intervention-based experimental design provides a higher-resolution path forward for microbiome research

2019 ◽  
Vol 42 ◽  
Author(s):  
J. Alfredo Blakeley-Ruiz ◽  
Carlee S. McClintock ◽  
Ralph Lydic ◽  
Helen A. Baghdoyan ◽  
James J. Choo ◽  
...  
Keyword(s):  
Systems Biology ◽  
High Resolution ◽  
Experimental Design ◽  
Integrated Systems ◽  
Microbiome Research ◽  
Constructive Criticism

Abstract The Hooks et al. review of microbiota-gut-brain (MGB) literature provides a constructive criticism of the general approaches encompassing MGB research. This commentary extends their review by: (a) highlighting capabilities of advanced systems-biology “-omics” techniques for microbiome research and (b) recommending that combining these high-resolution techniques with intervention-based experimental design may be the path forward for future MGB research.

Quantitative accuracy of serotonergic neurotrans-mission imaging with high-resolution 123I SPECT

2004 ◽  
Vol 43 (06) ◽  
pp. 185-189 ◽  
Author(s):  
J. T. Kuikka
Keyword(s):  
High Resolution ◽  
Scatter Correction ◽  
Region Of Interest ◽  
Binding Potential ◽  
Partial Volume ◽  
Therapeutic Drugs ◽  
Quantitative Accuracy ◽  
Critical Error ◽  
Statistical Noise

Summary Aim: Serotonin transporter (SERT) imaging can be used to study the role of regional abnormalities of neurotransmitter release in various mental disorders and to study the mechanism of action of therapeutic drugs or drugs’ abuse. We examine the quantitative accuracy and reproducibility that can be achieved with high-resolution SPECT of serotonergic neurotransmission. Method: Binding potential (BP) of 123I labeled tracer specific for midbrain SERT was assessed in 20 healthy persons. The effects of scatter, attenuation, partial volume, mis-registration and statistical noise were estimated using phantom and human studies. Results: Without any correction, BP was underestimated by 73%. The partial volume error was the major component in this underestimation whereas the most critical error for the reproducibility was misplacement of region of interest (ROI). Conclusion: The proper ROI registration, the use of the multiple head gamma camera with transmission based scatter correction introduce more relevant results. However, due to the small dimensions of the midbrain SERT structures and poor spatial resolution of SPECT, the improvement without the partial volume correction is not great enough to restore the estimate of BP to that of the true one.

Which is the role of dynamic high-resolution ultrasound (D-HRUS) in the assessment of plantar plate tears?

2008 ◽  
Vol 29 (S 1) ◽  
Author(s):  
LM Sconfienza ◽  
F Lacelli ◽  
G Grillo ◽  
G Serafini ◽  
G Garlaschi ◽  
...  
Keyword(s):  
High Resolution ◽  
Plantar Plate

High-Resolution CT in Paraquat Poisoning of the Lung: Role of Prognosis Prediction

1998 ◽  
Vol 38 (6) ◽  
pp. 1027
Author(s):  
Kyoung Suk Kim ◽  
Young Tong Kim ◽  
Eun Joo Kwon ◽  
Choung Sik Choi ◽  
Han Heag Im ◽  
...  
Keyword(s):  
High Resolution ◽  
Prognosis Prediction ◽  
High Resolution Ct ◽  
Paraquat Poisoning
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