Rapid additive-free bacteria lysis using traveling surface acoustic waves in microfluidic channels

Lab on a Chip ◽  
2019 ◽  
Vol 19 (24) ◽  
pp. 4064-4070 ◽  
Author(s):  
Haiwei Lu ◽  
Kirk Mutafopulos ◽  
John A. Heyman ◽  
Pascal Spink ◽  
Liang Shen ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Acoustic Waves ◽  
High Efficiency ◽  
Surface Acoustic Waves ◽  
Microfluidic Channels ◽  
Wide Range

We introduce a microfluidic device that uses traveling surface acoustic waves to lyse bacteria with high efficiency. This lysis method should be applicable to a wide range of bacteria species and can be modified to analyze individual bacteria cells.

scholarly journals Visualization of Surface Acoustic Waves in Thin Liquid Films

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
R. W. Rambach ◽  
J. Taiber ◽  
C. M. L. Scheck ◽  
C. Meyer ◽  
J. Reboud ◽  
...  
Keyword(s):  
Liquid Film ◽  
Acoustic Waves ◽  
Low Cost ◽  
Thin Liquid Film ◽  
Surface Acoustic Waves ◽  
Liquid Films ◽  
Theoretical Description ◽  
Propagation Path ◽  
Microfluidic Channels ◽  
Potential Applications

Abstract We demonstrate that the propagation path of a surface acoustic wave (SAW), excited with an interdigitated transducer (IDT), can be visualized using a thin liquid film dispensed onto a lithium niobate (LiNbO3) substrate. The practical advantages of this visualization method are its rapid and simple implementation, with many potential applications including in characterising acoustic pumping within microfluidic channels. It also enables low-cost characterisation of IDT designs thereby allowing the determination of anisotropy and orientation of the piezoelectric substrate without the requirement for sophisticated and expensive equipment. Here, we show that the optical visibility of the sound path critically depends on the physical properties of the liquid film and identify heptane and methanol as most contrast rich solvents for visualization of SAW. We also provide a detailed theoretical description of this effect.

scholarly journals Wide range of droplet jetting angles by thin-film based surface acoustic waves

2020 ◽  
Vol 53 (35) ◽  
pp. 355402 ◽  
Author(s):  
Jie Li ◽  
Mehdi H Biroun ◽  
Ran Tao ◽  
Yong Wang ◽  
Hamdi Torun ◽  
...  
Keyword(s):  
Thin Film ◽  
Acoustic Waves ◽  
Surface Acoustic Waves ◽  
Wide Range

Full Band-Gap Silicon Phononic Crystals for Surface Acoustic Waves

2006 ◽  
Author(s):  
Saeed Mohammadi ◽  
Abdelkrim Khelif ◽  
Ryan Westafer ◽  
Eric Massey ◽  
William D. Hunt ◽  
...  
Keyword(s):  
Band Gap ◽  
Acoustic Waves ◽  
Phononic Crystal ◽  
Surface Acoustic Waves ◽  
Hexagonal Lattice ◽  
Phononic Crystals ◽  
Bulk Wave ◽  
Filling Fraction ◽  
Phononic Band Gap ◽  
Wide Range

Periodic elastic structures, called phononic crystals, show interesting frequency domain characteristics that can greatly influence the performance of acoustic and ultrasonic devices for several applications. Phononic crystals are acoustic counterparts of the extensively-investigated photonic crystals that are made by varying material properties periodically. Here we demonstrate the existence of phononic band-gaps for surface acoustic waves (SAWs) in a half-space of two dimensional phononic crystals consisting of hexagonal (honeycomb) arrangement of air cylinders in a crystalline Silicon background with low filling fraction. A theoretical calculation of band structure for bulk wave using finite element method is also achieved and shows that there is no complete phononic band gap in the case of the low filling fraction. Fabrication of the holes in Silicon is done by optical lithography and deep Silicon dry etching. In the experimental characterization, we have used slanted finger interdigitated transducers deposited on a thin layer of Zinc oxide (sputtered on top of the phononic crystal structure to excite elastic surface waves in Silicon) to cover a wide range of frequencies. We believe this to be the first reported demonstration of phononic band-gap for SAWs in a hexagonal lattice phononic crystal at such a high frequency.

scholarly journals Selective cell encapsulation, lysis, pico-injection and size-controlled droplet generation using traveling surface acoustic waves in a microfluidic device

Lab on a Chip ◽  
2020 ◽  
Vol 20 (21) ◽  
pp. 3914-3921
Author(s):  
Kirk Mutafopulos ◽  
Peter J. Lu ◽  
Ryan Garry ◽  
Pascal Spink ◽  
David A. Weitz
Keyword(s):  
Microfluidic Device ◽  
Acoustic Waves ◽  
Single Cells ◽  
Surface Acoustic Waves ◽  
Cell Encapsulation ◽  
Droplet Generation ◽  
New Materials ◽  
On Demand ◽  
Interdigital Transducer ◽  
Size Controlled

We generate traveling surface acoustic waves with an interdigital transducer to create droplets on-demand; encapsulate single cells; lyse cells and immediately encapsulate their contents; and pico-inject new materials into existing droplets.

High Efficiency Mixing Chip with Liquid Flow Actuators Operated by Surface Acoustic Waves

2012 ◽  
Vol 132 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Tsunemasa Saiki ◽  
Yuichi Utsumi
Keyword(s):  
Liquid Flow ◽  
Acoustic Waves ◽  
High Efficiency ◽  
Surface Acoustic Waves

Enhanced particle focusing in microfluidic channels with standing surface acoustic waves

2010 ◽  
Vol 87 (5-8) ◽  
pp. 1204-1206 ◽  
Author(s):  
Q. Zeng ◽  
H.W.L. Chan ◽  
X.Z. Zhao ◽  
Y. Chen
Keyword(s):  
Acoustic Waves ◽  
Surface Acoustic Waves ◽  
Microfluidic Channels ◽  
Particle Focusing

scholarly journals ZnO Nanowire-Anchored Microfluidic Device With Herringbone Structure Fabricated by Maskless Photolithography

2020 ◽  
Vol 11 ◽  
pp. 117959722094143
Author(s):  
Dilshan Sooriyaarachchi ◽  
Shahrima Maharubin ◽  
George Z Tan
Keyword(s):  
Turbulent Flows ◽  
Microfluidic Device ◽  
High Efficiency ◽  
Kidney Diseases ◽  
Microfluidic Devices ◽  
Zno Nanowires ◽  
Nanowire Arrays ◽  
Microfluidic Channels ◽  
Zno Nanowire ◽  
Zno Nanowire Arrays

The integration of nanomaterials in microfluidic devices has emerged as a new research paradigm. Microfluidic devices composed of ZnO nanowires have been developed for the collection of urine extracellular vesicles (EVs) at high efficiency and in situ extraction of various microRNAs (miRNAs). The devices can be used for diagnosing various diseases, including kidney diseases and cancers. A major research need for developing micro total analysis systems is to enhance extraction efficiency. This article presents a novel fabrication method for a herringbone-patterned microfluidic device anchored with ZnO nanowire arrays. The substrates with herringbone patterns were created by maskless photolithography. The ZnO nanowire arrays were grown on the substrates by chemical bathing. The patterned design was to introduce turbulent flows as opposed to laminar flow in traditional devices to increase the mixing and contact of the urine sample with ZnO nanowires. The device showed reduced flow rates compared with conventional planar microfluidic channels and successfully extracted urine EV-encapsulated miRNAs.

High-Efficiency Mixing Chip with Liquid Flow Actuators Operated by Surface Acoustic Waves

2013 ◽  
Vol 97 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Tsunemasa Saiki ◽  
Yuichi Utsumi
Keyword(s):  
Liquid Flow ◽  
Acoustic Waves ◽  
High Efficiency ◽  
Surface Acoustic Waves
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