scholarly journals Highly sensitive mutation quantification by high-dynamic-range capillary-array electrophoresis (HiDy CE)

Lab on a Chip ◽  
2020 ◽  
Vol 20 (6) ◽  
pp. 1083-1091 ◽  
Author(s):  
Takashi Anazawa ◽  
Hiroko Matsunaga ◽  
Shuhei Yamamoto ◽  
Ryoji Inaba
Keyword(s):  
Dynamic Range ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Wild Type ◽  
Large Excess ◽  
Capillary Array Electrophoresis ◽  
Highly Sensitive ◽  
High Dynamic ◽  
Capillary Array

Mutant (MT) in a large excess of wild type (WT) was quantified with high-sensitivity (LOD of 0.004% MT/WT) and four-orders-of-magnitude dynamic range (0.01–100% MT/WT) by a high-dynamic-range capillary-array electrophoresis (HiDy CE).

scholarly journals Ultra-high dynamic range quantum measurement retaining its sensitivity

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
E. D. Herbschleb ◽  
H. Kato ◽  
T. Makino ◽  
S. Yamasaki ◽  
N. Mizuochi
Keyword(s):  
Dynamic Range ◽  
Large Range ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Current Field ◽  
Standard Measurement ◽  
Quantum Properties ◽  
Highly Sensitive ◽  
High Dynamic ◽  
Measurement Concept

AbstractQuantum sensors are highly sensitive since they capitalise on fragile quantum properties such as coherence, while enabling ultra-high spatial resolution. For sensing, the crux is to minimise the measurement uncertainty in a chosen range within a given time. However, basic quantum sensing protocols cannot simultaneously achieve both a high sensitivity and a large range. Here, we demonstrate a non-adaptive algorithm for increasing this range, in principle without limit, for alternating-current field sensing, while being able to get arbitrarily close to the best possible sensitivity. Therefore, it outperforms the standard measurement concept in both sensitivity and range. Also, we explore this algorithm thoroughly by simulation, and discuss the T−2 scaling that this algorithm approaches in the coherent regime, as opposed to the T−1/2 of the standard measurement. The same algorithm can be applied to any modulo-limited sensor.

scholarly journals Electronic Optical Sky Surveys

1998 ◽  
Vol 179 ◽  
pp. 49-55
Author(s):  
T.A. McKay
Keyword(s):  
Dynamic Range ◽  
Large Fraction ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Low Noise ◽  
Computer Hardware ◽  
Optical Detectors ◽  
Small Fields ◽  
Technical Advances ◽  
High Dynamic

The introduction of of Charge Coupled Devices (CCDs) in the middle 1970s provided astronomy with nearly perfect (linear, high-sensitivity, low-noise, high dynamic-range, digital) optical detectors. Unfortunately, restrictions imposed by CCD production and cost has typically limited their use to observations of relatively small fields. Recently a combination of technical advances have made practical the application of CCDs to survey science. CCD mosaic cameras, which help overcome the size restrictions imposed by CCD manufacture, allow electronic access to a larger fraction of the available focal plane. Multi-fiber spectrographs, which couple the low-noise, high QE performance of CCDs with the ability to observe spectra for many objects at once, have improved the spectroscopic efficiency of telescopes by factors approaching half a million. An improved understanding of image distortion gives us telescopes on which we expect sub-arcsecond images a large fraction of the time. Finally, and perhaps most important, the performance of computer hardware continues to advance, to the point where analysis of multi-terabyte datasets, while still daunting, is at least conceivable.

scholarly journals Missing flux in VLBI observations of SiO maser at 7 mm in IRC+10011

2017 ◽  
Vol 13 (S336) ◽  
pp. 387-388
Author(s):  
J.-F. Desmurs ◽  
J. Alcolea ◽  
V. Bujarrabal ◽  
F. Colomer ◽  
R. Soria-Ruiz
Keyword(s):  
Dynamic Range ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Total Flux ◽  
Agb Stars ◽  
Maser Emission ◽  
Spectral Channel ◽  
Emission Area ◽  
Vlbi Observations ◽  
High Dynamic

AbstractVLBI observations of SiO masers recover at most 40-50% of the total flux obtained by single dish observations at any spectral channel. Some previous studies seems to indicate that, at least, part of the lost flux is divided up into many weak components rather than in a large resolved emission area. Taking benefit of the high sensitivity and resolution of the HSA, we investigate the problem of the missing flux in VLBI observations of SiO maser emission at 7 mm in the AGB stars and obtain a high dynamic range map of IRC+10011. We conclude that the missing flux is mostly contained in many very weak maser components.

Integrated Hybrid MEMS Hydrogen Sensor with High Sensitivity and High Dynamic Range

2020 ◽  
Vol 140 (7) ◽  
pp. 158-164
Author(s):  
Yumi Hayashi ◽  
Hiroaki Yamazaki ◽  
Kei Masunishi ◽  
Daiki Ono ◽  
Tomohiro Saito ◽  
...  
Keyword(s):  
Dynamic Range ◽  
High Sensitivity ◽  
Hydrogen Sensor ◽  
High Dynamic Range ◽  
High Dynamic

scholarly journals An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range

Lab on a Chip ◽  
2017 ◽  
Vol 17 (24) ◽  
pp. 4231-4242 ◽  
Author(s):  
Takashi Anazawa ◽  
Motohiro Yamazaki
Keyword(s):  
Dynamic Range ◽  
Detection System ◽  
High Sensitivity ◽  
High Dynamic Range ◽  
Image Sensor ◽  
High Dynamic ◽  
Photo Detection

Fluorescence from four emission points is collimated by four lenses, split into four-color fluxes by four dichroic mirrors, and directly input into the image sensor.

Sign in / Sign up

Export Citation Format

Share Document