Intestine-penetrating, pH-sensitive and double-layered nanoparticles for oral delivery of doxorubicin with reduced toxicity

2019 ◽  
Vol 7 (23) ◽  
pp. 3692-3703 ◽  
Author(s):  
Min Sun ◽  
Dapeng Li ◽  
Xin Wang ◽  
Le He ◽  
Xiaodong Lv ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Oral Delivery ◽  
Ph Sensitive ◽  
Oral Toxicity ◽  
Absorption Effect ◽  
Reduced Toxicity

Herein, CMC-coated double-layered nanoparticles were prepared to induce the oral toxicity of doxorubicin via the intestinal absorption effect.

Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems

2001 ◽  
Vol 70 (1-2) ◽  
pp. 139-147 ◽  
Author(s):  
Muhammad Baluom ◽  
Michael Friedman ◽  
Abraham Rubinstein
Keyword(s):  
Intestinal Absorption ◽  
Oral Delivery ◽  
Delivery Systems ◽  
Oral Delivery Systems

Preparation andin vitroevaluation of new pH-sensitive hydrogel beads for oral delivery of protein drugs

2010 ◽  
Vol 115 (5) ◽  
pp. 2828-2837 ◽  
Author(s):  
I. M. El-Sherbiny ◽  
E. M. Abdel-Bary ◽  
D. R. K. Harding
Keyword(s):  
Oral Delivery ◽  
Ph Sensitive ◽  
Protein Drugs ◽  
Hydrogel Beads ◽  
Ph Sensitive Hydrogel

A novel pH-sensitive interferon-β (INF-β) oral delivery system for application in multiple sclerosis

2013 ◽  
Vol 456 (2) ◽  
pp. 459-472 ◽  
Author(s):  
Pierre P.D. Kondiah ◽  
Lomas K. Tomar ◽  
Charu Tyagi ◽  
Yahya E. Choonara ◽  
Girish Modi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Delivery System ◽  
Oral Delivery ◽  
Ph Sensitive ◽  
Interferon Β ◽  
Oral Delivery System

Synthesis of CSK-DEX-PLGA Nanoparticles for the Oral Delivery of Exenatide to Improve Its Mucus Penetration and Intestinal Absorption

2019 ◽  
Vol 16 (2) ◽  
pp. 518-532 ◽  
Author(s):  
Yina Song ◽  
Yanan Shi ◽  
Liping Zhang ◽  
Haiyan Hu ◽  
Chunyan Zhang ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Oral Delivery ◽  
Plga Nanoparticles ◽  
Mucus Penetration

pH-sensitive polymer-based carriers as a useful approach for oral delivery of therapeutic protein: A review

2021 ◽  
Vol 28 ◽  
Author(s):  
Maryam Shamseddini lori ◽  
Mandana Ohadi ◽  
Mohammad Amin Raeisi Estabragh ◽  
Sepehr Afsharipour ◽  
Ibrahim M Banat ◽  
...  
Keyword(s):  
Spatial Structure ◽  
Oral Delivery ◽  
Protein A ◽  
Protein Structures ◽  
Ph Sensitive ◽  
Hydrophilic Nature ◽  
Stomach Acid ◽  
Correct Function ◽  
Ph Sensitive Polymer ◽  
The Stability

: There are many proteins and enzymes in the human body, and their dysfunction can lead to disease. The use of proteins as a drug is common in various diseases such as diabetes. Proteins are hydrophilic molecules whose spatial structure is critical to their correct function. There are different ways to the administration of proteins. Protein structures are degraded by gastric acid and enzymes in the gastrointestinal tract and have a slight ability to permeation from the gastrointestinal epithelium due to their large hydrophilic nature. Therefore, their oral use has limitations. Since the oral use of drugs is one of the best and easiest routes for patients, many studies have been done to increase the stability, penetration and ultimately increase the bioavailability of proteins through oral administration. One of the studied strategies for oral delivery of protein is the use of pH-sensitive polymer-based carriers. These carriers use different pH-sensitive polymers such as eudragit®, chitosan, dextran, and alginate. The use of pH-sensitive polymer-based carriers by protecting the protein from stomach acid (low pH) and degrading enzymes, increasing permeability, and maintaining the spatial structure of the protein leads to increased bioavailability. In this review, we focus on the various polymers used to prepare pH-sensitive polymer-based carriers for the oral delivery of proteins.

Sign in / Sign up

Export Citation Format

Share Document