High-efficiency fluorescent and magnetic multimodal probe for long-term monitoring and deep penetration imaging of tumors

High-quality multimodal imaging requires exogenous contrast agents with high sensitivity, spatial–temporal resolution, and high penetration depth for the accurate diagnosis and surveillance of cancer.

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Development and Assembly of a MEMS Based High-Sensitivity Relative Gravimeter for Multi-Pixel Imaging Applications

10.5194/egusphere-egu21-13167 ◽

2021 ◽

Author(s):

Karl Toland ◽

Abhinav Prasad ◽

Andreas Noack ◽

Kristian Anastasiou ◽

Richard Middlemiss ◽

...

Keyword(s):

High Sensitivity ◽

Cost Effective ◽

Mount Etna ◽

Earth Tides ◽

Gravity Measurements ◽

Stepper Motors ◽

Long Term Monitoring ◽

The Stability ◽

Term Monitoring

The manufacture and production of a&#160;high-sensitivity&#160;cost-effective gravimeter has the potential to change the&#160;methodology&#160;and efficiency&#160;of gravity measurements. Currently,&#160;the&#160;most common&#160;method&#160;to conduct a survey is&#160;by using&#160;a single gravimeter, usually costing tens of thousands of Dollars,&#160;with measurements taken at multiple locations to&#160;obtain the required data.&#160;The availability of a cost-effective gravimeter&#160;however would allow the user to install multiple gravimeters, at the same cost of a single gravimeter,&#160;to increase the efficiency of&#160;surveys and long-term monitoring.&#160;&#160;&#160;Since the previous reporting on a low-drift relative MEMS gravimeter for multi-pixel imaging applications (Prasad, A. et al,&#160;EGU2020-18528), significant&#160;progress&#160;has&#160;been made in the&#160;development and assembly of the previously reported system. Field prototypes have been manufactured and undergone significant testing&#160;to investigate the stability and robustness of the system&#160;in preparation for&#160;the&#160;deployment&#160;of multiple devices&#160;as part of the gravity imager on Mount Etna. The device, known as Wee-g, has several key features which makes it an attractive prospect in the field of gravimetry. Examples of these features are that the Wee-g is small and portable with the ability to connect to the device remotely, can be powered through a mains connected power supply, or through portable batteries, weighs under 4kg, has a low power consumption during normal use of 5W, correct for tilt through manual adjustments or remotely through integrated stepper motors with a total tilt correction range of 5 degrees, the ability to read out tilt of the device through an inclinometer for either alignment or long term monitoring and numerous temperature sensors and heater servos to control the temperature of the MEMS to <1mK.&#160;This presentation aims to report on the progress that has been achieved&#160;in the&#160;development and&#160;manufacturing of the prototype devices, various testing of the devices under various laboratory conditions (such as the measurements of the Earth tides, and a relative measurement of gravity at various floor levels), as well as additional&#160;applications that are to be explored in 2021.&#160;

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Differential Surface Plasmon Resonance Sensor for the Detection of Chemicals and Biochemicals

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.543.310 ◽

2013 ◽

Vol 543 ◽

pp. 310-313 ◽

Cited By ~ 3

Author(s):

Carmelo Fallauto ◽

Guido Perrone ◽

Alberto Vallan

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Plasmon Resonance ◽

High Sensitivity ◽

Practical Implementation ◽

Resonance Sensor ◽

Order Of Magnitude ◽

Long Term Monitoring ◽

Term Monitoring

Surface plasmon resonance is one the most common optical sensing techniques for the detection of chemicals and biochemicals, although still mainly confined to lab applications. Typically, these sensors are made by a thin gold layer deposited on a glass prism or on an optical fiber similar to those used in telecom applications. Key advantages of this technique are the possibility to specifically detect different chemicals through functionalization of the metal surface and the high sensitivity, although the latter may turn into a weakness in long term monitoring applications due to cross-sensitivity to parasitic effects. To overcome this limitation the paper proposes a novel sensor implementation with a cascaded double sensing area, particularly suited for long term monitoring of pollutant since one sensing area is actually used to detect the desired molecules, while the other for compensating drifts due to fluctuations, misalignments and temperature variations. The paper addresses mainly the prism-based implementation, but the proposed configuration is suited also for an all-fiber approach. Examples of practical implementation of the proposed techniques are given, evidencing an accuracy improvement of more than an order of magnitude.

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Infectious Causes of Acute and Chronic Sinusitis

10.5772/intechopen.99603 ◽

2021 ◽

Author(s):

Jana I. Preis ◽

Anna W. Maro ◽

Sophie Hurez ◽

Sneha Pusapati

Keyword(s):

Nasal Cavity ◽

Paranasal Sinuses ◽

Shock Absorber ◽

Accurate Diagnosis ◽

Duration Of Symptoms ◽

Prevention Therapy ◽

Long Term Monitoring ◽

Term Monitoring

Paranasal sinuses anatomy is paired in 4 parts which includes frontal, maxillary, ethmoid, and sphenoid. Their relevant function is to secrete mucous for moisture, humidify inspired air, impart vocal resonance, and act as shock absorber for intracranial contents. Retention of secretions in the nasal cavity and sinuses can cause inflammation of the mucosa of paranasal sinuses and lead to infection. Classification of sinusitis is based on duration of symptoms. Diagnosis can be achieved clinically, however other diagnosis modalities such as cultures or radiology can help to achieve accurate diagnosis. Depending on the etiology management can be supportive or pharmacological. In some cases, long term monitoring and prevention therapy may be required.

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