scholarly journals Ratiometric fluorescent probes based on through-bond energy transfer of cyanine donors to near-infrared hemicyanine acceptors for mitochondrial pH detection and monitoring of mitophagy

2020 ◽  
Vol 8 (8) ◽  
pp. 1603-1615 ◽  
Author(s):  
Shuai Xia ◽  
Jianbo Wang ◽  
Yibin Zhang ◽  
Nick Whisman ◽  
Jianheng Bi ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Fluorescent Probes ◽  
Bond Energy ◽  
Near Infrared ◽  
Ph Changes ◽  
Highly Efficient ◽  
Ph Detection

Two ratiometric near-infrared fluorescent probes (A and B) have been developed to selectively and accurately detect mitochondrial pH changes based on highly efficient through-bond energy transfer (TBET) from cyanine donors to near-infrared-emissive hemicyanine acceptors.

Near‐Infrared Bioluminescence Imaging with a through‐Bond Energy Transfer Cassette

ChemBioChem ◽  
2019 ◽  
Vol 20 (15) ◽  
pp. 1919-1923 ◽  
Author(s):  
Masahiro Abe ◽  
Ryo Nishihara ◽  
Yuma Ikeda ◽  
Takahiro Nakajima ◽  
Moritoshi Sato ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Bond Energy ◽  
Near Infrared ◽  
Bioluminescence Imaging

scholarly journals Cover Feature: Near‐Infrared Bioluminescence Imaging with a through‐Bond Energy Transfer Cassette (ChemBioChem 15/2019)

ChemBioChem ◽  
2019 ◽  
Vol 20 (15) ◽  
pp. 1870-1870
Author(s):  
Masahiro Abe ◽  
Ryo Nishihara ◽  
Yuma Ikeda ◽  
Takahiro Nakajima ◽  
Moritoshi Sato ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Bond Energy ◽  
Near Infrared ◽  
Bioluminescence Imaging

scholarly journals Ratiometric Near-Infrared Fluorescent Probes Based on Hemicyanine Dyes Bearing Dithioacetal and Formal Residues for pH Detection in Mitochondria

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 2088
Author(s):  
Yunnan Yan ◽  
Yibin Zhang ◽  
Shuai Xia ◽  
Shulin Wan ◽  
Tara Vohs ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Formyl Group ◽  
Pka Values ◽  
Theoretical Methods ◽  
Hemicyanine Dye ◽  
Hemicyanine Dyes ◽  
Experimental Values ◽  
Van Der Waals Radii ◽  
Ph Detection

Ratiometric near-infrared fluorescent probes (AH+ and BH+) have been prepared for pH determination in mitochondria by attaching dithioacetal and formal residues onto a hemicyanine dye. The reactive formyl group on probe BH+ allows for retention inside mitochondria as it can react with a protein primary amine residue to form an imine under slightly basic pH 8.0. Probes AH+ and BH+ display ratiometric fluorescent responses to pH changes through the protonation and deprotonaton of a hydroxy group in hemicyanine dyes with experimentally determined pKa values of 6.85 and 6.49, respectively. Calculated pKa values from a variety of theoretical methods indicated that the SMDBONDI method of accounting for solvent and van der Waals radii plus including a water molecule located near the site of protonation produced the closest overall agreement with the experimental values at 7.33 and 6.14 for AH+ and BH+ respectively.

scholarly journals Fluorescent probes for sensitive and selective detection of pH changes in live cells in visible and near-infrared channels

2017 ◽  
Vol 5 (48) ◽  
pp. 9579-9590 ◽  
Author(s):  
Mingxi Fang ◽  
Rashmi Adhikari ◽  
Jianheng Bi ◽  
Wafa Mazi ◽  
Nethaniah Dorh ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Live Cells ◽  
Selective Detection ◽  
Ph Changes ◽  
Ring Structures

Five fluorescent probes bearing coumarin moieties with spirolactam ring structures have been developed to detect pH changes in visible and near-infrared channels.

A visible-near-infrared fluorescent probe for peroxynitrite with large pseudo-Stokes and emission shift via through-bond energy and charge transfers controlled by energy matching

2018 ◽  
Vol 6 (16) ◽  
pp. 2489-2496 ◽  
Author(s):  
Yuxin Guo ◽  
Gonghao Lu ◽  
Jiezhen Zhuo ◽  
Jiayu Wang ◽  
Xue Li ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Charge Transfer ◽  
Fluorescent Probe ◽  
Bond Energy ◽  
Near Infrared ◽  
Intramolecular Charge Transfer

We reported a visible-near-infrared fluorescent probe for peroxynitrite detection with large pseudo-Stokes and emission shifts, based on through-bond energy transfer (TBET) in combination with intramolecular charge transfer (ICT).

A smart two-photon fluorescent platform based on desulfurization–cyclization: a phthalimide–rhodamine chemodosimeter for Hg2+ NIR emission at 746 nm and through-bond energy transfer

2017 ◽  
Vol 41 (22) ◽  
pp. 13495-13503 ◽  
Author(s):  
Shan-kun Yao ◽  
Ying Qian ◽  
Zheng-qing Qi ◽  
Chang-gui Lu ◽  
Yi-ping Cui
Keyword(s):  
Energy Transfer ◽  
Bond Energy ◽  
Near Infrared ◽  
Infrared Region ◽  
Two Photon ◽  
Nir Emission ◽  
Near Infrared Region ◽  
Fluorescent Chemodosimeter

In this work, a smart two-photon fluorescent platform based on desulfurization–cyclization was developed, in the construction of TBET-based fluorescent chemodosimeter CyRSN towards Hg2+ in near-infrared region at 746 nm.

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