Marcus Vinicius Martins Rubatino
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Ana Laura Araújo Santos
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Rayssa Araújo dos Santos
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Magali Benjamim de Araújo
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Roxithromycin is one of the most frequently used macrolide antibiotics, a safe group of antimicrobials that acts
against Gram-positive bacteria and some Gram-negative bacteria. It is sold in several countries in different dosage forms
(tablets and capsules) and strengths (50, 100, 150 and 300 mg). Several analytical methods have been described to
quantify roxithromycin in different matrices, such as biological and environmental samples and food. Identifying the main
characteristics of the drugs and selecting appropriate analytical methods for their quantification are of paramount
importance for understanding the behavior of drugs, metabolites and impurities. This review presents the physicalchemical and microbiological characteristics, properties as well as methods for quantification of roxithromycin in
biological fluids, pharmaceutical preparations, food and environmental samples. HPLC coupled to various detection
systems is the most used analytical technique to determine roxithromycin in these matrices. Although many analytical
methods have been reported for the analysis of this drug, it is very important to include in this context a prospective view,
in order to implement new analytical technologies for the quality control of this antimicrobial that contribute to the
preservation of economic and environmental impacts.
Recent advances in de novo protein design: principles, methods, and applications