A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

2020 ◽  
Vol 56 (69) ◽  
pp. 9986-9989
Author(s):  
Amit Kumar Singh ◽  
Moumita Kundu ◽  
Samrat Roy ◽  
Biswajit Roy ◽  
Sk. Sheriff Shah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photon Absorption ◽  
Cancer Drug ◽  
Real Time Monitoring ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Anti Cancer

A two-photon responsive drug delivery system having two-photon absorption (TPA) in the phototherapeutic window with a two-photon uncaging cross-section ≥10 GM and exhibiting real-time monitoring of anti-cancer drug release.

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

Reduction-responsive gold-nanoparticle-conjugated Pluronic micelles: an effective anti-cancer drug delivery system

2012 ◽  
Vol 22 (36) ◽  
pp. 18864 ◽  
Author(s):  
Youhua Tao ◽  
Jiangfeng Han ◽  
Chunting Ye ◽  
Tima Thomas ◽  
Huanyu Dou
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticle ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals A sustained intravitreal drug delivery system with remote real time monitoring capability

2015 ◽  
Vol 24 ◽  
pp. 309-321 ◽  
Author(s):  
Huiyuan Hou ◽  
Alejandra Nieto ◽  
Akram Belghith ◽  
Kaihui Nan ◽  
Yangyang Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Real Time Monitoring ◽  
Intravitreal Drug Delivery

scholarly journals A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yoshinori Inagaki ◽  
Takashi Kokudo ◽  
Mako Kamiya ◽  
Shin-nosuke Uno ◽  
Masumitsu Sato ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Indocyanine Green ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

2020 ◽  
Vol 192 ◽  
pp. 111068 ◽  
Author(s):  
Kejing Shi ◽  
Rodrigo Aviles-Espinosa ◽  
Elizabeth Rendon-Morales ◽  
Lisa Woodbine ◽  
Mohammed Maniruzzaman ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Anti Cancer ◽  
3D Printed ◽  
Cancer Drug Delivery

Preparation of biodegradable PEGylated pH/reduction dual-stimuli responsive nanohydrogels for controlled release of an anti-cancer drug

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 12051-12060 ◽  
Author(s):  
Tingting Zhou ◽  
Xubo Zhao ◽  
Lei Liu ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Stimuli Sensitive

Monodisperse biodegradable PEGylated pH and reduction dual-stimuli sensitive PMPB nanohydrogels were prepared as a drug delivery system for controlled release anti-cancer drugs.

A magnetically guided anti-cancer drug delivery system using porous FePt capsules

Biomaterials ◽  
2012 ◽  
Vol 33 (5) ◽  
pp. 1682-1687 ◽  
Author(s):  
Teruaki Fuchigami ◽  
Ryo Kawamura ◽  
Yoshitaka Kitamoto ◽  
Masaru Nakagawa ◽  
Yoshihisa Namiki
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery
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