Synthesis of deuterated γ-linolenic acid and application for biological studies: metabolic tuning and Raman imaging

2021 ◽  
Author(s):  
Kosuke Dodo ◽  
Ayato Sato ◽  
Yuki Tamura ◽  
Syusuke Egoshi ◽  
Koichi Fujiwara ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Raman Imaging ◽  
Metabolic Inhibition ◽  
Mechanistic Studies ◽  
Selective Cytotoxicity ◽  
Dual Functional ◽  
Biological Studies ◽  
Tumor Selective

γ-Linolenic acid (GLA) is reported to show tumor-selective cytotoxicity via unidentified mechanisms. We introduced deuterium into GLA as a dual functional tag for metabolic inhibition and Raman imaging and applied for mechanistic studies.

Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators

1996 ◽  
Vol 7 (5) ◽  
pp. 548-557 ◽  
Author(s):  
Tetsuhiko Shirasaka ◽  
Yuji Shimamato ◽  
Hideyuki Ohshimo ◽  
Masahiro Yamaguchi ◽  
Toshiyuki Kato ◽  
...  
Keyword(s):  
Selective Cytotoxicity ◽  
Tumor Selective

scholarly journals Tumor-selective Cytotoxicity of a Novel Pentadiene Analogue on Human Leukemia/lymphoma Cells

2016 ◽  
Vol 3 (2) ◽  
pp. 138-146 ◽  
Author(s):  
Yahaira Santiago-Vázquez ◽  
Umashankar Das ◽  
Armando Varela-Ramirez ◽  
Sarah T. Baca ◽  
Yoshira Ayala-Marin ◽  
...  
Keyword(s):  
Human Leukemia ◽  
Lymphoma Cells ◽  
Selective Cytotoxicity ◽  
Tumor Selective

Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam.

2009 ◽  
Vol 65 (4) ◽  
pp. 719-726 ◽  
Author(s):  
Hironori Iwasaki ◽  
Takafumi Okabe ◽  
Kensaku Takara ◽  
Takayoshi Toda ◽  
Masayuki Shimatani ◽  
...  
Keyword(s):  
Selective Cytotoxicity ◽  
Toddalia Asiatica ◽  
Tumor Selective

Hybrid polymer micelles capable of cRGD targeting and pH-triggered surface charge conversion for tumor selective accumulation and promoted uptake

2014 ◽  
Vol 50 (65) ◽  
pp. 9188-9191 ◽  
Author(s):  
Xiuli Hu ◽  
Xingang Guan ◽  
Jing Li ◽  
Qing Pei ◽  
Ming Liu ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Surface Charge ◽  
Active Targeting ◽  
Hybrid Polymer ◽  
Polymer Micelles ◽  
Dual Functional ◽  
Stimuli Response ◽  
Selective Accumulation ◽  
Tumor Selective

Dual functional micelles combining active targeting (cRGD) and tumor microenvironment stimuli response used for Dox delivery.

Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase

2007 ◽  
Vol 86 (1) ◽  
pp. 117-128 ◽  
Author(s):  
Jung-Hyun Park ◽  
Hyun-Soon Jong ◽  
Sang Gyun Kim ◽  
Yeonjoo Jung ◽  
Keun-Wook Lee ◽  
...  
Keyword(s):  
Histone Deacetylases ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Selective Cytotoxicity ◽  
Tumor Selective

scholarly journals Development and application of Raman microspectroscopic and Raman imaging techniques for cell biological studies

1995 ◽  
Vol 347 ◽  
pp. 477-483 ◽  
Author(s):  
G.J Puppels ◽  
T.C.Bakker Schut ◽  
N.M Sijtsema ◽  
M Grond ◽  
F Maraboeuf ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Raman Imaging ◽  
Biological Studies

Modification of the Electron Microscope for Investigation of Fully Hydrated Biological Specimens

1969 ◽  
Vol 27 ◽  
pp. 418-419 ◽  
Author(s):  
R. C. Moretz ◽  
D. F. Parsons
Keyword(s):  
Electron Beam ◽  
Electron Microscope ◽  
Structural Damage ◽  
Lower Percentage ◽  
Vacuum Drying ◽  
Total Removal ◽  
Total Absence ◽  
Biological Studies ◽  
Electron Microscopes ◽  
Beam Damage

Short lifetime or total absence of electron diffraction of ordered biological specimens is an indication that the specimen undergoes extensive molecular structural damage in the electron microscope. The specimen damage is due to the interaction of the electron beam (40-100 kV) with the specimen and the total removal of water from the structure by vacuum drying. The lower percentage of inelastic scattering at 1 MeV makes it possible to minimize the beam damage to the specimen. The elimination of vacuum drying by modification of the electron microscope is expected to allow more meaningful investigations of biological specimens at 100 kV until 1 MeV electron microscopes become more readily available. One modification, two-film microchambers, has been explored for both biological and non-biological studies.

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