Catalytic asymmetric preparation of pyrroloindolines: strategies and applications to total synthesis

2021 ◽  
Author(s):  
Guang-Jian Mei ◽  
Wai Lean Koay ◽  
Chuan Xiang Alvin Tan ◽  
Yixin Lu
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
State Of The Art ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

Pyrroloindolines are widely present in natural products. In this review, we summarize state-of-the-art of catalytic asymmetric synthesis of pyrroloindolines, as well as related applications to natural products total synthesis.

scholarly journals Catalytic asymmetric synthesis of biologically important 3-hydroxyoxindoles: an update

2016 ◽  
Vol 12 ◽  
pp. 1000-1039 ◽  
Author(s):  
Bin Yu ◽  
Hui Xing ◽  
De-Quan Yu ◽  
Hong-Min Liu
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Drug Discovery ◽  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Biological Activities ◽  
Transition Metal Catalysis ◽  
Metal Catalysis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

Oxindole scaffolds are prevalent in natural products and have been recognized as privileged substructures in new drug discovery. Several oxindole-containing compounds have advanced into clinical trials for the treatment of different diseases. Among these compounds, enantioenriched 3-hydroxyoxindole scaffolds also exist in natural products and have proven to possess promising biological activities. A large number of catalytic asymmetric strategies toward the construction of 3-hydroxyoxindoles based on transition metal catalysis and organocatalysis have been reported in the last decades. Additionally, 3-hydroxyoxindoles as versatile precursors have also been used in the total synthesis of natural products and for constructing structurally novel scaffolds. In this review, we aim to provide an overview about the catalytic asymmetric synthesis of biologically important 3-substituted 3-hydroxyoxindoles and 3-hydroxyoxindole-based further transformations.

Catalytic asymmetric synthesis of natural products with heterocyclic rings

1998 ◽  
Vol 35 (5) ◽  
pp. 1057-1064 ◽  
Author(s):  
Masakatsu Shibasaki ◽  
Akihiko Kojima ◽  
Satoshi Shimizu
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

Organometallics-Based Catalytic (Asymmetric) Synthesis of Natural Products

2018 ◽  
pp. 191-259
Author(s):  
Hongbin Zhai ◽  
Yun Li ◽  
Bin Cheng ◽  
Zhiqiang Ma ◽  
Peng Gao ◽  
...  
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

Direct catalytic asymmetric synthesis of α-chiral primary amines

2020 ◽  
Vol 49 (17) ◽  
pp. 6141-6153
Author(s):  
Qin Yin ◽  
Yongjie Shi ◽  
Jingxin Wang ◽  
Xumu Zhang
Keyword(s):  
Asymmetric Synthesis ◽  
State Of The Art ◽  
The State ◽  
Primary Amines ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric

This review highlights the state-of-the-art catalytic methods for the direct asymmetric synthesis of α-chiral primary amines and demonstrates their utility in the construction of molecular complexities.

Enantioselective Syntheses of Yohimbine Alkaloids: Proving Grounds for New Catalytic Transformations

Synthesis ◽  
2021 ◽  
Author(s):  
Karl A. Scheidt ◽  
Eric R Miller
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
Total Synthesis ◽  
State Of The Art ◽  
The State ◽  
Catalytic Transformations ◽  
Bond Forming ◽  
The Past ◽  
Catalytic Asymmetric ◽  
Enantioselective Syntheses

The total synthesis of bioactive alkaloids is an enduring challenge and an indication of the state of the art of chemical synthesis. With the explosion of catalytic asymmetric methods over the past three decades, these compelling targets have been fertile proving grounds for enantioselective bond forming transformations. We summarize these activities herein both to highlight the power and versatility of these methods and to instill future inspiration for new syntheses of these privileged natural products.

Atroposelective Carbonylation of Aryl Iodides with Amides: Facile Synthesis of Enantioenriched Cyclic and Acyclic Amides

2021 ◽  
Author(s):  
Li-Ping Chen ◽  
Jiangfei Chen ◽  
Yu-Jiao Zhang ◽  
Xingyi He ◽  
Ya-Fei Han ◽  
...  
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Bioactive Molecules ◽  
Facile Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Aryl Iodides ◽  
Axially Chiral ◽  
Catalytic Asymmetric

Axially chiral cyclic and acyclic amides are frequently found in natural products and bioactive molecules, but their versatilely catalytic asymmetric synthesis with high enantioselectivities and good yields has been a...

ChemInform Abstract: Catalytic Asymmetric Synthesis of Natural Products with Heterocyclic Rings

ChemInform ◽  
2010 ◽  
Vol 30 (9) ◽  
pp. no-no
Author(s):  
Masakatsu Shibasaki ◽  
Akihiko Kojima ◽  
Satoshi Shimizu
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Catalytic Asymmetric Synthesis ◽  
Catalytic Asymmetric
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