scholarly journals Advances in polycyclization cascades in natural product synthesis

2021 ◽  
Author(s):  
Yubo Jiang ◽  
Ryan E. McNamee ◽  
Philip J. Smith ◽  
Ana Sozanschi ◽  
Zixuan Tong ◽  
...  
Keyword(s):  
Natural Product ◽  
Cascade Reactions ◽  
Single Step ◽  
Natural Product Synthesis ◽  
Ring Systems ◽  
Recent Advances ◽  
Powerful Means ◽  
Multiple Ring

Cascade reactions are among the most powerful means to achieve the construction of multiple ring systems in a single step. This tutorial review describes recent advances in the use of polycyclization cascades in natural product synthesis.

ChemInform Abstract: Recent Advances in Biomimetic Natural Product Synthesis

ChemInform ◽  
2008 ◽  
Vol 39 (27) ◽  
Author(s):  
Paul G. Bulger ◽  
Sharan K. Bagal ◽  
Rodolfo Marquez
Keyword(s):  
Natural Product ◽  
Natural Product Synthesis ◽  
Recent Advances

scholarly journals Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis

Molecules ◽  
2016 ◽  
Vol 21 (7) ◽  
pp. 951 ◽  
Author(s):  
Seung-Mann Paek ◽  
Myeonggyo Jeong ◽  
Jeyun Jo ◽  
Yu Heo ◽  
Young Han ◽  
...  
Keyword(s):  
Amino Acids ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Asymmetric Induction ◽  
Recent Advances

scholarly journals Recent Advance of Domino Michael Reaction in Natural Product Synthesis

2021 ◽  
Vol 16 (10) ◽  
pp. 1934578X2110498
Author(s):  
Hisahiro Hagiwara
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Michael Reaction ◽  
Natural Product Synthesis ◽  
Total Syntheses ◽  
Michael Reactions ◽  
Recent Advances ◽  
Key Steps ◽  
Related Compounds

Recent advances in the total syntheses of cyclic natural products and related compounds from 2005 to 2021, which employ domino Michael reactions as key steps, have been reviewed, focusing mainly on the domino Michael reactions catalyzed by organocatalysts.

scholarly journals All-carbon [3 + 2] cycloaddition in natural product synthesis

2020 ◽  
Vol 16 ◽  
pp. 3015-3031
Author(s):  
Zhuo Wang ◽  
Junyang Liu
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Structural Features ◽  
Single Step ◽  
Natural Product Synthesis ◽  
Synthetic Chemistry ◽  
Quaternary Centers ◽  
Chemical Structures ◽  
Quaternary Center ◽  
Medicinal Properties

Many natural products possess interesting medicinal properties that arise from their intriguing chemical structures. The highly-substituted carbocycle is one of the most common structural features in many structurally complicated natural products. However, the construction of highly-substituted, stereo-congested, five-membered carbocycles containing all-carbon quaternary center(s) is, at present, a distinct challenge in modern synthetic chemistry, which can be accessed through the all-carbon [3 + 2] cycloaddition. More importantly, the all-carbon [3 + 2] cycloaddition can forge vicinal all-carbon quaternary centers in a single step and has been demonstrated in the synthesis of complex natural products. In this review, we present the development of all-carbon [3 + 2] cycloadditions and illustrate their application in natural product synthesis reported in the last decade covering 2011–2020 (inclusive).

scholarly journals Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods

2015 ◽  
Vol 68 (4) ◽  
pp. 693 ◽  
Author(s):  
Sonja B. Kamptmann ◽  
Steven V. Ley
Keyword(s):  
Natural Product ◽  
Flow Chemistry ◽  
Single Step ◽  
Natural Product Synthesis ◽  
Biomimetic Synthesis ◽  
Synthetic Chemistry ◽  
Chemical Methods ◽  
Complex Architectures

Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis. Here we show the syntheses of borrerine derived alkaloids, indicating that we can use biomimetic principles in flow to prepare complex architectures in a single step.

Recent Advances in Steroid Synthesis: A Tribute to Sir Derek Barton

2018 ◽  
Vol 71 (9) ◽  
pp. 627
Author(s):  
Kieran D. Jones ◽  
Scott G. Stewart
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Methyl Ether ◽  
Ring System ◽  
Natural Product Synthesis ◽  
Steroid Synthesis ◽  
Research Areas ◽  
Recent Advances

The synthesis of steroids and gaining an ultimate understanding of their reactivity was one of Sir Derek Barton’s most notable research areas. This highlight will focus on the construction of the steroid ring system from 2016 to 2018, and will include pathways that eventually led to natural product synthesis. For example, efficient syntheses of ent-pregnanolone sulfate and oestradiol methyl ether will be explained along with the total synthesis of cannogenol-3-O-α-l-rhamnoside.

Recent Advances in Natural Product Synthesis by Using Intramolecular Diels−Alder Reactions†

2005 ◽  
Vol 105 (12) ◽  
pp. 4779-4807 ◽  
Author(s):  
Ken-ichi Takao ◽  
Ryosuke Munakata ◽  
Kin-ichi Tadano
Keyword(s):  
Natural Product ◽  
Diels Alder ◽  
Natural Product Synthesis ◽  
Recent Advances
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