Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing

Lab on a Chip ◽  
2020 ◽  
Vol 20 (22) ◽  
pp. 4205-4214
Author(s):  
Yihang Chen ◽  
Shiming Zhang ◽  
Qingyu Cui ◽  
Jiahua Ni ◽  
Xiaochen Wang ◽  
...  

Microchannels created in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogels have the potential to prevent dry-eye disease by facilitating tear exchange. Biosensors are further demonstrated for wearable biosensing applications.

2016 ◽  
Vol 163 ◽  
pp. 167-173.e1 ◽  
Author(s):  
Sarah La Porta Weber ◽  
Rodrigo Becco de Souza ◽  
José Álvaro Pereira Gomes ◽  
Ana Luisa Hofling-Lima

PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0258217
Author(s):  
Chantaka Supiyaphun ◽  
Passara Jongkhajornpong ◽  
Sasivimol Rattanasiri ◽  
Kaevalin Lekhanont

Purpose To investigate the prevalence of dry eye disease (DED) and its associated risk factors among Thai university students. Methods A cross-sectional study using an electronic survey was conducted in two Rajabhat universities in Bangkok, Thailand. The woman’s health study questionnaire was used to determine students with DED. The prevalence of DED along with 95% confidence interval (CI) were calculated. Logistic regression model was used to identify the associated risk factors. Results A total of 4,111 university students joined and completed the survey questionnaires. Mean age was 18.8 ± 1.1 years with female predominance (2874 students, 69.91%). Clinically diagnosed DED was reported in 136 students (3.31%), while severe symptoms of eye dryness and irritation were reported in 227 students (5.52%). The prevalence of DED among Thai university students was 8.15% (95% CI 7.33% to 9.02%). History of contact lens use and high screen time (> 8 hours per day) were reported in 868 students (21.11%) and 2101 students (51.11%), respectively. Male gender, contact lens use and high screen time were significantly associated with higher risk of DED with the adjusted ORs (95% CI) of 1.39 (1.09, 1.77), 2.49 (1.96, 3.17), and 1.43 (1.14, 1.80), respectively. Conclusions DED is not rare among Thai university students. Contact lens use and high screen time are two significant modifiable risk factors of DED in our students. These findings can raise awareness of DED in youth population and provide valuable information for public health promotion in university students.


2013 ◽  
pp. 77-77
Author(s):  
Heiko Pult ◽  
Jason Nichols

2018 ◽  
Vol 542 ◽  
pp. 84-94 ◽  
Author(s):  
Ramachandram Badugu ◽  
Bennie H. Jeng ◽  
E. Albert Reece ◽  
Joseph R. Lakowicz

2021 ◽  
Author(s):  
Nianhong Wang ◽  
Dan Chen ◽  
Yan Liu ◽  
Huan Weng ◽  
Huiying Wang ◽  
...  

Abstract Background To investigate the current status, morbidity, and risk factors of functional dry eye disease (DED) in Shanghai's working-class population. On this basis, exploring measures and methods to fundamentally cure and prevent functional DED. Methods A questionnaire form was used to record the data of the diagnosed functional DED working-class subjects in Shanghai, the results were recorded and analyzed. Additionally, the subjective symptoms of DED subjects and the respective clinical results were also recorded. The classification and corneal staining between subjects who wear contact lens or without were compared. The correlation of classification and corneal staining with their risk factors were also analyzed. Results The risk factors of functional DED showed much in common though their works have professional particularity. EDE accounts for a large proportion of DED (45.35%), many subjects coexist symptoms and signs of mixed DED (32.64%). The age of 21–40 is the peak year range (70.4%). Contact lens, visual terminals, air-conditioner, decoration, stay up later, sleep disorder, smoking were risk factors in most functional DED subjects. Notably, contact lens is a leading risk factor to cause functional DED and ocular surface complications (both were p < 0.01), while deep sleep seems to be a protective factor (p < 0.01%). Conclusion The incidence of functional DED in Shanghai is kept in a high level, most risk factors are closely related to daily work and life, while they are almost reversible. Exploring and eradicating these daily risk factors seems to be a more preferable way to fundamentally control and prevent functional DED.


2020 ◽  
Vol 9 (3) ◽  
pp. 1-4
Author(s):  
Madhavi Chevuturu

Background: Dry eye is a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance.   The present study was conducted to assess prevalence and risk factors of dry eye diseases among the study group. Subjects and Methods:  The present study was conducted from February 2018 to July 2018 on 184 patients of both genders visiting the Department of Ophthalmology Mediciti institute of medical sciences with eye complaints. Slit-lamp biomicroscopy with a cobalt blue filter was used to investigate the tear film layer, and the interval from the last blink to the appearance of the first random dry spot on the cornea was noted. Schirmer’s test was performed. Whatman filter paper no 41 was placed in the lower fornix at the lateral one-third of the lower lid margin. Results: Age groups 40-50 years had 52, 50-60 years had 98 and 60-70 years had 34 patients. There were 110 males and 74 females. The difference was significant (P< 0.05). 64 (58.1%) males and 40 (54%) had a dry eye disease. The prevalence found to be 61.9%. The severity of DED was mild in 25%, moderate in 46% and severe in 29%. The difference was significant (P< 0.05). Risk factors of DED were steroid use in 14%, smoking in 56%, alcoholism in 24%, computer job in 78%, systemic allergy in 4%, ocular allergy in 32%, contact lens use in 17% and previous ocular surgery in 7%. The difference was significant (P< 0.05). Conclusion: The author found that the prevalence rate of dry eyes was 61.9%. Risk factors of DED were steroid use, smoking, alcoholism, computer job, systemic allergy, ocular allergy, contact lens use and previous ocular surgery.


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