Reversibly-regulated drug release using poly(tannic acid) fabricated nanocarriers for reduced secondary side effects in tumor therapy

2020 ◽  
Vol 5 (6) ◽  
pp. 986-998
Author(s):  
Chao Chen ◽  
Tonghao Ma ◽  
Wen Tang ◽  
Xiaoli Wang ◽  
Yibing Wang ◽  
...  
Keyword(s):  
Side Effects ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Tannic Acid ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Ph Responsive ◽  
Normal Tissues ◽  
Secondary Side

This article introduced a reversibly pH-responsive and targeting nanocarrier based on mesoporous silica nanoparticles which could be utilized to reduce the “secondary” side effects on normal tissues.

pH-Sensitive nanogates based on poly(l-histidine) for controlled drug release from mesoporous silica nanoparticles

2016 ◽  
Vol 7 (7) ◽  
pp. 1475-1485 ◽  
Author(s):  
Panayiotis Bilalis ◽  
Leto-A. Tziveleka ◽  
Spyridon Varlas ◽  
Hermis Iatrou
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Ph Responsive

Mesoporous silica nanoparticles (MSNs) bearing poly(l-histidine)-grafted nanogates were prepared by surface-initiated ROP. The obtained polypeptide-functionalized MSNs were used as smart pH-responsive nanocarriers for controlled drug release applications.

Gas-generating mesoporous silica nanoparticles with rapid localized drug release for enhanced chemophotothermal tumor therapy

2020 ◽  
Vol 8 (23) ◽  
pp. 6754-6763
Author(s):  
Zhiming Zhang ◽  
Li Zhang ◽  
Chenlu Huang ◽  
Qing Guo ◽  
Yueyue Zuo ◽  
...  
Keyword(s):  
Drug Release ◽  
Combination Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Tumor Therapy ◽  
Promising Strategy

Chemophotothermal combination therapy has emerged as a novel and promising strategy to treat cancer.

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