scholarly journals Tantalum oxide nanoparticles as versatile contrast agents for X-ray computed tomography

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7720-7734 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy M. L. Hix ◽  
Kaitlyn A. Wiewiora ◽  
Maximilian C. Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Tantalum Oxide ◽  
Oxide Nanoparticles ◽  
Vast Array ◽  
X Ray ◽  
Nanoparticle Delivery ◽  
X Ray Computed ◽  
Surface Chemistries

Radiopaque tantalum oxide (TaOx) nanoparticles can be fabricated with a variety of surface chemistries enabling the use of computed tomography to image a vast array of important biolgical phenomena and nanoparticle delivery schemes.

Tantalum Oxide Nanoparticles as Versatile Contrast Agents for X-ray Computed Tomography

2020 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy Hix ◽  
Kaitlyn Wieweora ◽  
Maximilian Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Tantalum Oxide ◽  
High Signal ◽  
Drug Delivery Vehicles ◽  
X Ray Computed

Here we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaOx) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaOx nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaOx NCs demonstrate high CT contrast, circulation in blood for ~ 3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated. Partially hydrophilic NCs were encapsulated within mesoporous silica nanoparticles (MSNPs; TaOx@MSNPs) and hydrophobic NCs were encapsulated within poly(lactic-co-glycolic acid) (PLGA; TaOx@PLGA) NPs, serving as potential CT-imagable drug delivery vehicles. Bolus intramuscular injections of TaOx@PLGA NPs and TaOx@MSNPs to mimic the accumulation of NPs at a tumor site produce high signal enhancement in mice. In vitro studies on bare NCs and formuated NPs demonstrate high cytocompatibility and low dissolution of TaOx. This work solidifies that TaOx-based NPs are versatile contrast agents for CT.

X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer

2010 ◽  
Vol 21 (24) ◽  
pp. 245104 ◽  
Author(s):  
Chie Kojima ◽  
Yasuhito Umeda ◽  
Mikako Ogawa ◽  
Atsushi Harada ◽  
Yasuhiro Magata ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Seeded Growth ◽  
X Ray ◽  
X Ray Computed

CMR 2007: 8.03: Gold nanoparticles as contrast agents for MRI and X-ray computed tomography imaging

2007 ◽  
Vol 2 (6) ◽  
pp. 292-293
Author(s):  
S. Roux ◽  
C. Alric ◽  
J. Taleb ◽  
C. Mandon ◽  
C. Billotey ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Computed Tomography Imaging ◽  
X Ray ◽  
Tomography Imaging ◽  
X Ray Computed

Tantalum Oxide Nanoparticles as Versatile Contrast Agents for X-ray Computed Tomography

2020 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy Hix ◽  
Kaitlyn Wieweora ◽  
Maximilian Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Tantalum Oxide ◽  
High Signal ◽  
Drug Delivery Vehicles ◽  
X Ray Computed

Here we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaOx) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaOx nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaOx NCs demonstrate high CT contrast, circulation in blood for ~ 3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated. Partially hydrophilic NCs were encapsulated within mesoporous silica nanoparticles (MSNPs; TaOx@MSNPs) and hydrophobic NCs were encapsulated within poly(lactic-co-glycolic acid) (PLGA; TaOx@PLGA) NPs, serving as potential CT-imagable drug delivery vehicles. Bolus intramuscular injections of TaOx@PLGA NPs and TaOx@MSNPs to mimic the accumulation of NPs at a tumor site produce high signal enhancement in mice. In vitro studies on bare NCs and formuated NPs demonstrate high cytocompatibility and low dissolution of TaOx. This work solidifies that TaOx-based NPs are versatile contrast agents for CT.

New Tungsten Cluster Based Contrast Agents for X-ray Computed Tomography

2014 ◽  
Vol 26 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Detlev Sülzle ◽  
Marcus Bauser ◽  
Thomas Frenzel ◽  
Gregor Jost ◽  
Hubertus Pietsch ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
X Ray ◽  
X Ray Computed

Inorganic Nanoparticles Based Contrast Agents for X-ray Computed Tomography

2012 ◽  
Vol 1 (4) ◽  
pp. 413-431 ◽  
Author(s):  
Anshuman Jakhmola ◽  
Nicolas Anton ◽  
Thierry F. Vandamme
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Inorganic Nanoparticles ◽  
X Ray ◽  
X Ray Computed
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