Tantalum Oxide Nanoparticles for the Imaging of Articular Cartilage Using X-Ray Computed Tomography: Visualization of Ex Vivo/In Vivo Murine Tibia and Ex Vivo Human Index Finger Cartilage

2014 ◽  
Vol 126 (32) ◽  
pp. 8546-8550 ◽  
Author(s):  
Jonathan D. Freedman ◽  
Hrvoje Lusic ◽  
Brian D. Snyder ◽  
Mark W. Grinstaff
Keyword(s):  
Computed Tomography ◽  
Articular Cartilage ◽  
Index Finger ◽  
Ex Vivo ◽  
Tantalum Oxide ◽  
Oxide Nanoparticles ◽  
X Ray ◽  
X Ray Computed

Mineralization of Sialoliths Investigated by Ex Vivo and In Vivo X-ray Computed Tomography

2019 ◽  
Vol 25 (1) ◽  
pp. 151-163 ◽  
Author(s):  
Pedro Nolasco ◽  
Paulo V. Coelho ◽  
Carla Coelho ◽  
David F. Angelo ◽  
J. R. Dias ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Computed Tomography ◽  
Organic Matter ◽  
Ex Vivo ◽  
Correct Selection ◽  
Quantitative Relation ◽  
Helical Computed Tomography ◽  
X Ray ◽  
X Ray Computed

AbstractThe fraction of organic matter present affects the fragmentation behavior of sialoliths; thus, pretherapeutic information on the degree of mineralization is relevant for a correct selection of lithotripsy procedures. This work proposes a methodology for in vivo characterization of salivary calculi in the pretherapeutic context. Sialoliths were characterized in detail by X-ray computed microtomography (μCT) in combination with atomic emission spectroscopy, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Correlative analysis of the same specimens was performed by in vivo and ex vivo helical computed tomography (HCT) and ex vivo μCT. The mineral matter in the sialoliths consisted essentially of apatite (89 vol%) and whitlockite (11 vol%) with average density of 1.8 g/cm3. In hydrated conditions, the mineral mass prevailed with 53 ± 13 wt%, whereas the organic matter, with a density of 1.2 g/cm3, occupied 65 ± 10% of the sialoliths’ volume. A quantitative relation between sialoliths mineral density and X-ray attenuation is proposed for both HCT and μCT.

scholarly journals Tantalum oxide nanoparticles as versatile contrast agents for X-ray computed tomography

Nanoscale ◽  
2020 ◽  
Vol 12 (14) ◽  
pp. 7720-7734 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy M. L. Hix ◽  
Kaitlyn A. Wiewiora ◽  
Maximilian C. Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Tantalum Oxide ◽  
Oxide Nanoparticles ◽  
Vast Array ◽  
X Ray ◽  
Nanoparticle Delivery ◽  
X Ray Computed ◽  
Surface Chemistries

Radiopaque tantalum oxide (TaOx) nanoparticles can be fabricated with a variety of surface chemistries enabling the use of computed tomography to image a vast array of important biolgical phenomena and nanoparticle delivery schemes.

scholarly journals Validation of an XCT/fDOT System on Mice

ISRN Optics ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Anne Koenig ◽  
Anne Planat-Chrétien ◽  
Kai Hassler ◽  
Martina Bucher ◽  
Jean-Guillaume Coutard ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Imaging System ◽  
Ex Vivo ◽  
Optical Tomography ◽  
Diffuse Optical Tomography ◽  
Cylindrical Geometry ◽  
X Ray ◽  
Dual Modality ◽  
X Ray Computed

In this paper we present systems for dual modality imaging, combining fluorescence-enhanced diffuse optical tomography and X-ray computed tomography. Fluorescence diffuse optical tomography is carried out in a cylindrical geometry, which ensures optimal sampling and a straight forward integration with the X-ray modality. Specific acquisition protocols and reconstruction software have been developed to this end. The X-ray computed tomography serves two purposes. First, it provides the anatomical information in the registered dual modality images. Second, it provides the actual shape and boundaries of the animal as a priori input to the fluorescence reconstruction algorithm. To evaluate the performance of the optical imaging system, experiments have been conducted on phantoms, mice with inserted fluorescing capillaries, and finally on mice bearing tumors, ex-vivo and in-vivo. Experiments on mice with capillaries inserted in different region of interest, allow estimating the detection limits of fluorophore concentrations. The fluorescence reconstructions are shown to be geometrically consistent with the X-ray images. Finally we demonstrate the capability of the bimodal system to localize real tumours in mice in-vivo. These results show that dual modality fluorescence-enhanced diffuse optical tomography and X-ray computed tomography imaging in cylindrical geometry has a high potential for small animal tumour evolution studies.

Tantalum Oxide Nanoparticles as Versatile Contrast Agents for X-ray Computed Tomography

2020 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy Hix ◽  
Kaitlyn Wieweora ◽  
Maximilian Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Tantalum Oxide ◽  
High Signal ◽  
Drug Delivery Vehicles ◽  
X Ray Computed

Here we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaOx) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaOx nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaOx NCs demonstrate high CT contrast, circulation in blood for ~ 3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated. Partially hydrophilic NCs were encapsulated within mesoporous silica nanoparticles (MSNPs; TaOx@MSNPs) and hydrophobic NCs were encapsulated within poly(lactic-co-glycolic acid) (PLGA; TaOx@PLGA) NPs, serving as potential CT-imagable drug delivery vehicles. Bolus intramuscular injections of TaOx@PLGA NPs and TaOx@MSNPs to mimic the accumulation of NPs at a tumor site produce high signal enhancement in mice. In vitro studies on bare NCs and formuated NPs demonstrate high cytocompatibility and low dissolution of TaOx. This work solidifies that TaOx-based NPs are versatile contrast agents for CT.

PEG modified BaGdF5:Yb/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging

Biomaterials ◽  
2012 ◽  
Vol 33 (36) ◽  
pp. 9232-9238 ◽  
Author(s):  
Songjun Zeng ◽  
Ming-Kiu Tsang ◽  
Chi-Fai Chan ◽  
Ka-Leung Wong ◽  
Jianhua Hao
Keyword(s):  
Computed Tomography ◽  
X Ray ◽  
X Ray Computed ◽  
Biomagnetic Imaging

scholarly journals Multi-scale X-ray computed tomography to detect and localize metal-based nanomaterials in lung tissues of in vivo exposed mice

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Perrine Chaurand ◽  
Wei Liu ◽  
Daniel Borschneck ◽  
Clément Levard ◽  
Mélanie Auffan ◽  
...  
Keyword(s):  
Computed Tomography ◽  
X Ray ◽  
Multi Scale ◽  
X Ray Computed

scholarly journals Evaluation of Regenerative Processes in a Rat Model of Mandibular Condyle Defect using in vivo Micro X-Ray Computed Tomography

2012 ◽  
Vol 21 (4) ◽  
pp. 407-412 ◽  
Author(s):  
Tadahito Saito ◽  
Takayuki Mashimo ◽  
Hiroshi Shiratsuchi ◽  
Shunsuke Namaki ◽  
Kunihito Matsumoto ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Rat Model ◽  
Mandibular Condyle ◽  
Regenerative Processes ◽  
X Ray ◽  
X Ray Computed

A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging

2011 ◽  
Vol 124 (6) ◽  
pp. 1466-1471 ◽  
Author(s):  
Yanlan Liu ◽  
Kelong Ai ◽  
Jianhua Liu ◽  
Qinghai Yuan ◽  
Yangyang He ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
High Performance ◽  
Computed Tomography Imaging ◽  
X Ray ◽  
Tomography Imaging ◽  
X Ray Computed

Tantalum Oxide Nanoparticles as Versatile Contrast Agents for X-ray Computed Tomography

2020 ◽  
Author(s):  
Shatadru Chakravarty ◽  
Jeremy Hix ◽  
Kaitlyn Wieweora ◽  
Maximilian Volk ◽  
Elizabeth Kenyon ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agents ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Tantalum Oxide ◽  
High Signal ◽  
Drug Delivery Vehicles ◽  
X Ray Computed

Here we describe the synthesis, characterization and in vitro and in vivo performance of a series of tantalum oxide (TaOx) based nanoparticles (NPs) for computed tomography (CT). Five distinct versions of 9-12 nm diameter silane coated TaOx nanocrystals (NCs) were fabricated by a sol-gel method with varying degrees of hydrophilicity and with or without fluorescence, with the highest reported Ta content to date (78%). Highly hydrophilic NCs were left bare and were evaluated in vivo in mice for micro-CT of full body vasculature, where following intravenous injection, TaOx NCs demonstrate high CT contrast, circulation in blood for ~ 3 h, and eventual accumulation in RES organs; and following injection locally in the mammary gland, where the full ductal tree structure can be clearly delineated. Partially hydrophilic NCs were encapsulated within mesoporous silica nanoparticles (MSNPs; TaOx@MSNPs) and hydrophobic NCs were encapsulated within poly(lactic-co-glycolic acid) (PLGA; TaOx@PLGA) NPs, serving as potential CT-imagable drug delivery vehicles. Bolus intramuscular injections of TaOx@PLGA NPs and TaOx@MSNPs to mimic the accumulation of NPs at a tumor site produce high signal enhancement in mice. In vitro studies on bare NCs and formuated NPs demonstrate high cytocompatibility and low dissolution of TaOx. This work solidifies that TaOx-based NPs are versatile contrast agents for CT.

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