Current Understanding of Water Properties inside Carbon Nanotubes

Confined water inside carbon nanotubes (CNTs) has attracted a lot of attention in recent years, amassing as a result a very large number of dedicated studies, both theoretical and experimental. This exceptional scientific interest can be understood in terms of the exotic properties of nanoconfined water, as well as the vast array of possible applications of CNTs in a wide range of fields stretching from geology to medicine and biology. This review presents an overreaching narrative of the properties of water in CNTs, based mostly on results from systematic nuclear magnetic resonance (NMR) and molecular dynamics (MD) studies, which together allow the untangling and explanation of many seemingly contradictory results present in the literature. Further, we identify still-debatable issues and open problems, as well as avenues for future studies, both theoretical and experimental.

Atomic-Scale Characterization of Structural Heterogeny in 2D TMD Layers

The heterogeneity features among 2-dimensional (2D) transition metal dichalcogenides (TMDs) layered materials endow them with distinctive properties for a vast array of novel applications. Their unique properties stem from the...

Multimodal Discourse Analysis of Egyptian Political Movies: Framing Social Justice in the Movie Ahl El Kemma (Cream of the Crop)

Nascent research is conducted on the advancement of discourse analysis in film to include different modes as images, sound and text. This study is focused on how images are embedded within texts in an audio-visual medium such as cinema to highlight political messages; it also seeks to broaden our understanding of politics beyond a relatively narrow conceptualization of the "political" through studying non-traditional discourses such as cinematic discourse. The aim of the study is to develop a systematic approach to film analysis to examine political nuance sin film. The method adopted in this research is Multi modal Discourse Analysis (MDA) focusing on embedding visuals, audio, and text in the film to examine how a political meaning can be conveyed through the interaction between those different modes. Drawing on the multi modal discourse analysis literature, different modalities will be studied to understand how those modes interact in the cinematic discourse. The film, "Cream of the Crop", is selected as an example to examine how political meanings in film can tackle the cinematic representation of the notion of social justice. This study contributes to the vast array of literature on the multi modal discourse analysis of films by focusing on political dynamics within them.

Sugar-Derived Amidines and Congeners: Structures, Glycosidase Inhibition and Applications

Glycosidases, the enzymes responsible for the breakdown of glycoconjugates including di-, oligo- and polysaccharides are ubiquitous through all kingdoms of life. The extreme chemical stability of the glycosidic bond combined with the catalytic rates achieved by glycosidases makes them among the most proficient of all enzymes. Given their multitude of roles in vivo, inhibition of these enzymes is highly attractive with potential in the treatment of a vast array of pathologies ranging from lysosomal storage and diabetes to viral infections. Therefore great efforts have been invested in the last three decades to design and synthesize inhibitors of glycosidases leading to a number of drugs currently on the market. Amongst the vast array of structures that have been disclosed, sugars incorporating an amidine moiety have been the focus of many research groups around the world because of their glycosidase transition state-like structure. In this review we report and discuss the structure, the inhibition profile and the use of these molecules including related structural congeners as transition state analogs.

Spaces of Communication

Semio-pragmatics, an approach to the study of film and audiovisual media first proposed by Roger Odin in the early 1980s, shifted the focus from textual analysis to the interaction of text and context and to the institutional modes of framing and reading which shape the viewer’s engagement with the film. A response to an impasse in post-1968 film semiotics and psychoanalytical approaches to film spectatorship, semio-pragmatics contributed significantly to the further development of film studies alongside Cultural Studies, neo-formalism, historical reception studies and the phenomenology of film. Spaces of Communication offers a concise introduction to semio-pragmatics and condenses the intellectual trajectory of one of the foundational figures of film studies into a relatively short and accessible volume. It is a book which testifies to the author’s deep and rich intellectual engagement with a vast array of objects ranging from the classics of the cinephile canon to television news programs, home movies and mobile phone films.

Comparative longitudinal variation of total IgG and IgA anti-SARS-CoV-2 antibodies in recipients of BNT162b2 vaccination

Objectives This article aims to summarize the 6-month variation of a vast array of anti-SARS-CoV-2 antibodies in recipients of BNT162b2 mRNA-based vaccination. Methods The study population consisted of 84 baseline SARS-CoV-2 seronegative healthcare employees (median age 45 years, 53.6% females), receiving mRNA-based BNT162b2 primary vaccination cycle. Blood was collected before the first and second BNT162b2 vaccine doses, as well as 1, 3 and 6 months afterwards. The serum titers of the following anti-SARS-CoV-2 antibodies were assayed: total anti-RBD (receptor binding domain), anti-spike trimeric IgG, anti-RBD IgG and anti-spike S1 IgA. Results All antibodies’ levels peaked 1 month after vaccination, but then displayed a considerable decrease. The median rates of 6-month decline were −95% for IgG anti-SARS-CoV-2 RBD, −85% for IgG anti-SARS-CoV-2 trimeric spike, −73% for IgA anti-SARS-CoV-2 S1 and −56% for total anti-SARS-CoV-2 RBD antibodies, respectively. The median time of seronegativization was estimated at 579 days for total anti-SARS-CoV-2 RBD antibodies, 271 days for IgG anti-SARS-CoV-2 trimeric spike, 264 days for IgG anti-SARS-CoV-2 RBD and 208 days for IgA anti-SARS-CoV-2 S1, respectively. The rate of seropositive subjects declined from 98–100% at the peak to 50–100% after 6 months. The inter-individual variation of anti-SARS-CoV-2 antibodies reduction at 6 months was 3–44% from the peak. Conclusions The results of this longitudinal serosurvey demonstrate that the titer of anti-SARS-CoV-2 antibodies declined 6 months after BNT162b2 vaccination, with median time of IgG/IgA seronegativization estimated between 7 and 9 months, thus supporting the opportunity of administering vaccine boosters approximately 5 to 6 months after the last dose of the primary vaccination cycle.

Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants

Measuring the level of protection conferred by anti-SARS-CoV-2 (trimeric) spike or RBD (receptor binding domain) antibodies (especially total and IgG) is a suitable and reliable approach for predicting biological protection against the risk of infection and severe coronavirus disease 2019 (COVID-19) illness. Nonetheless, SARS-CoV-2 has undergone a broad process of recombination since the identification of the prototype lineage in 2019, introducing a huge number of mutations in its genome and generating a vast array of variants of interest (VoI) and concern (VoC). Many of such variants developed several mutations in spike protein and RBD, with the new Omicron (B.1.1.529) clade displaying over 30 changes, 15 of which concentrated in the RBD. Besides their impact on virus biology, as well as on the risk of detection failure with some molecular techniques (i.e., S gene dropout), recent evidence suggests that these mutations may also jeopardize the reliability of currently available commercial immunoassays for detecting anti-SARS-CoV-2 antibodies. The antigen (either spike or RBD) and epitopes of the prototype SARS-CoV-2 coated in some immunoassays may no longer reflect the sequence of circulating variants. On the other hand, anti-SARS-CoV-2 antibodies elicited by highly mutated SARS-CoV-2 variants may no longer be efficiently recognized by the currently available commercial immunoassays. Therefore, beside the compelling need to regularly re-evaluate and revalidate all commercially available immunoassays against live virus neutralization assays based on emerging VoCs or VoIs, diagnostic companies may also consider to redevelop their methods, replacing former SARS-CoV-2 antigens and epitopes with those of the new variants.

The quest for myriad strains

In the era in which the web is fully demonstrating its archival potential, more and more composers make use of sound, melody and computer library repositories. It is a clear trend in popular music, which is increasingly being extended also to ‘academic’ composition: today authors can access and contribute to a vast array of audio materials, of procedures and languages, where historicity and innovation coexist in an eternal present. At first glance it may seem a revolution. However, a closer look reveals ancient roots in the history of music that audio reproduction has made only more evident: the fixation of music on tape, at first, has led some composers (e.g. Bruno Maderna) to create sound libraries to be reused in different works, thus blurring the borders of the Opera; later on, the dematerialization and atomization of procedures in IT have pushed towards a philosophy of sharing (e.g. libraries for Computer Assisted Composition systems) – exalted today by the capillarity of the lightning-fast web distribution – raising deep questions about the concept of author itself. Moving further backwards, to the re-uses in Rossini and Mozart, or to the anonymous formulas in Gregorian chant, could we not find the recurrence of a quest for that world of «myriad strains that once shall sound», where the composer can stretch forth a hand for a musical idea, so wonderfully glimpsed by Busoni in his Sketch for a New Esthetic of Music?

Formation and degeneration of scaled capillary notochaetae in Owenia fusiformis Delle Chiaje, 1844 (Oweniidae, Annelida)

Phylotranscriptomic studies of the past decade have repeatedly placed Oweniidae together with Magelonidae, as the sister group to remaining annelids. This newly established placement clearly makes them a key-lineage for understanding annelid evolution and morphology. One of the most prominent morphological features of all annelids are their chaetae. The arrangement and formation process (chaetogenesis) of these chitinous bristles have been studied extensively in hooked chaetae that are arranged in rows. However, the information on other types of chaetae is still scarce. In this study, we investigated the scaled capillary notochaetae of Owenia fusiformis, looking both into the formation process that causes the scaly surface ornamentation and into their arrangement within tight bundles. Our results demonstrate the incredible plasticity of chaetogenesis that allows forming a vast array of three-dimensional structures. The capillary chaetae of Owenia fusiformis are unique in lacking an enamel coating and the scales covering the apical surface of each chaeta are formed by a single microvillus of the chaetoblast. Furthermore, the bundle of chaetae has a peripherally located formative site and a central degenerative site and it appears to result from a secondary curling of the chaetal sac.

Setting the agenda in environmental crisis: Relationships between tweets, Google search trends, and newspaper coverage during the California drought

Nuanced public responses to droughts and other chronic environmental crises reflect today’s increasingly complex communication ecosystem. At once global and infinitely customizable, this vast array of media and information channels requires existing theory to address the implications of interactions among social media, “traditional” mass media outlets, and information-seeking tools such as search engines. How do these channels intervene in public conversation? What might the agenda-setting perspective have to say? Data collected during peak years of the California drought, 2013–2015, indicate that California residents responded to worsening drought conditions Twitter first, which was the only media behavior directly stimulated by environmental stressors. Google searches stimulated newspaper coverage and Twitter activity, revealing the centrality of search behaviors in this environmental crisis. The findings suggest significant changes to the communication landscape as individual and collective users become increasingly dependent on non-mainstream media channels for information in chronic crisis situations.