scholarly journals Disruption of mitochondrial redox homeostasis by enzymatic activation of a trialkylphosphine probe

2021 ◽  
Author(s):  
Jade Nguyen ◽  
Alina Tirla ◽  
Pablo Rivera-Fuentes
Keyword(s):  
Stress Response ◽  
Morphological Changes ◽  
Redox Homeostasis ◽  
Integrated Stress Response ◽  
Enzymatic Activation

The release of tributylphosphine in mitochondria induces morphological changes and upregulates specific genes from the integrated stress response, such as CHAC1.

Hypercapnia impairs protein translation by activating integrated stress response

2018 ◽  
Author(s):  
V Kryvenko ◽  
W Seeger ◽  
I Vadász
Keyword(s):  
Stress Response ◽  
Protein Translation ◽  
Integrated Stress Response

scholarly journals Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma

2020 ◽  
Vol 37 (11) ◽  
pp. 1370-1380 ◽  
Author(s):  
Karen Krukowski ◽  
Amber Nolan ◽  
Elma S. Frias ◽  
Katherine Grue ◽  
McKenna Becker ◽  
...  
Keyword(s):  
Stress Response ◽  
Head Trauma ◽  
Integrated Stress Response

scholarly journals Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ai-Ling Tian ◽  
Qi Wu ◽  
Peng Liu ◽  
Liwei Zhao ◽  
Isabelle Martins ◽  
...  
Keyword(s):  
Stress Response ◽  
Immune Responses ◽  
Initiation Factor ◽  
Integrated Stress Response ◽  
Serine Residue ◽  
Eif2α Phosphorylation ◽  
Lysosomotropic Agents ◽  
Cultured Human Cells

AbstractThe integrated stress response manifests with the phosphorylation of eukaryotic initiation factor 2α (eIF2α) on serine residue 51 and plays a major role in the adaptation of cells to endoplasmic reticulum stress in the initiation of autophagy and in the ignition of immune responses. Here, we report that lysosomotropic agents, including azithromycin, chloroquine, and hydroxychloroquine, can trigger eIF2α phosphorylation in vitro (in cultured human cells) and, as validated for hydroxychloroquine, in vivo (in mice). Cells bearing a non-phosphorylatable eIF2α mutant (S51A) failed to accumulate autophagic puncta in response to azithromycin, chloroquine, and hydroxychloroquine. Conversely, two inhibitors of eIF2α dephosphorylation, nelfinavir and salubrinal, enhanced the induction of such autophagic puncta. Altogether, these results point to the unexpected capacity of azithromycin, chloroquine, and hydroxychloroquine to elicit the integrated stress response.

scholarly journals Targeting the integrated stress response in ophthalmology

2021 ◽  
pp. 1-14
Author(s):  
Hsiao-Sang Chu ◽  
Cornelia Peterson ◽  
Albert Jun ◽  
James Foster
Keyword(s):  
Stress Response ◽  
Integrated Stress Response

Targeting integrated stress response regulates microglial M1/M2 polarization and attenuates neuroinflammation following surgical brain injury in rat

2021 ◽  
pp. 110048
Author(s):  
Teng-chao Huang ◽  
Lun Luo ◽  
Shi-hai Jiang ◽  
Chuan Chen ◽  
Hai-yong He ◽  
...  
Keyword(s):  
Brain Injury ◽  
Stress Response ◽  
Integrated Stress Response ◽  
M2 Polarization ◽  
Surgical Brain Injury

scholarly journals Aging Accelerates Pulmonary Fibrosis Via the Activation of Integrated Stress Response and Recruitment of Monocyte-Derived Alveolar Macrophages

2020 ◽  
Author(s):  
S. Watanabe ◽  
N. Markov ◽  
Z. Lu ◽  
R. Piseaux Aillon ◽  
H. Abdala-Valencia ◽  
...  
Keyword(s):  
Stress Response ◽  
Pulmonary Fibrosis ◽  
Alveolar Macrophages ◽  
Integrated Stress Response
Sign in / Sign up

Export Citation Format

Share Document