scholarly journals Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

2020 ◽  
Vol 11 (44) ◽  
pp. 6988-7008 ◽  
Author(s):  
Duc Dung Nguyen ◽  
Jui-Yang Lai
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Disease Treatment ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Stimuli Response

Recent exploitations of stimuli-responsive polymers as ophthalmic drug delivery systems for the treatment of eye diseases are summarized and discussed.

scholarly journals Classification of stimuli–responsive polymers as anticancer drug delivery systems

Drug Delivery ◽  
2014 ◽  
Vol 22 (2) ◽  
pp. 145-155 ◽  
Author(s):  
Bita Taghizadeh ◽  
Shahrouz Taranejoo ◽  
Seyed Ali Monemian ◽  
Zoha Salehi Moghaddam ◽  
Karim Daliri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

scholarly journals Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

2010 ◽  
Vol 51 (11) ◽  
pp. 5403 ◽  
Author(s):  
Henry F. Edelhauser ◽  
Cheryl L. Rowe-Rendleman ◽  
Michael R. Robinson ◽  
Daniel G. Dawson ◽  
Gerald J. Chader ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Basic Research ◽  
Delivery Systems ◽  
Clinical Applications ◽  
Retinal Diseases ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

scholarly journals Polymer-Based Smart Drug Delivery Systems for Skin Application and Demonstration of Stimuli-Responsiveness

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1285
Author(s):  
Louise Van Gheluwe ◽  
Igor Chourpa ◽  
Coline Gaigne ◽  
Emilie Munnier
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Ex Vivo ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Stimuli Responsive Polymers ◽  
Smart Drug ◽  
Smart Drug Delivery

Progress in recent years in the field of stimuli-responsive polymers, whose properties change depending on the intensity of a signal, permitted an increase in smart drug delivery systems (SDDS). SDDS have attracted the attention of the scientific community because they can help meet two current challenges of the pharmaceutical industry: targeted drug delivery and personalized medicine. Controlled release of the active ingredient can be achieved through various stimuli, among which are temperature, pH, redox potential or even enzymes. SDDS, hitherto explored mainly in oncology, are now developed in the fields of dermatology and cosmetics. They are mostly hydrogels or nanosystems, and the most-used stimuli are pH and temperature. This review offers an overview of polymer-based SDDS developed to trigger the release of active ingredients intended to treat skin conditions or pathologies. The methods used to attest to stimuli-responsiveness in vitro, ex vivo and in vivo are discussed.

scholarly journals DEVELOPMENT, EVALUATION AND CHARACTERISTICS OF OPHTHALMIC IN SITU GEL SYSTEM: A REVIEW

2019 ◽  
pp. 47-53 ◽  
Author(s):  
MRINMOY DEKA ◽  
ABDUL BAQUEE AHMED ◽  
JASHOBIR CHAKRABORTY
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Temperature Modulation ◽  
Duration Of Action ◽  
In Situ Gel ◽  
Ophthalmic Drug Delivery ◽  
Sensitive Organ ◽  
Ophthalmic Drug

Eye is a sensitive organ and is easily injured and infected. Delivery of drugs into eye is complicated due to removal mechanism of precorneal area results decrease in therapeutic response. Conventional ocular delivery systems like solution, suspension, ointment shows some disadvantages such as rapid corneal elimination, repeated instillation of drug and short duration of action. In situ polymeric delivery system will help to achieve optimal concentration of drug at the target site, thereby helps to achieve the desired therapeutic concentration. There are various novel ocular drug delivery systems such as In-situ gel, dendrimers, niosomes, nanoparticulate system, collagen shield, ocular iontophoresis suspension and ocusert etc. In situ gelling systems are liquid upon instillation and undergo a phase transition to form gel due to some stimuli responses such as temperature modulation, change in pH and presence of ions. Various attempts have been made towards the development of stable sustained release in-situ gels. Newer research in ophthalmic drug delivery systems is directed towards an incorporation of several drug delivery technologies, that includes to build up systems which is not only extend the contact time of the vehicle at the ocular surface, but which at the same time slow down the removal of the drug. This is a review based on ocular in situ gels, characteristization, techniques and evaluation of in situ ophthalmic drug delivery systems,

scholarly journals Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

2015 ◽  
Vol 18 (5) ◽  
pp. 683 ◽  
Author(s):  
Andreza Maria Ribeiro ◽  
Ana Figueiras ◽  
Francisco Veiga
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Contact Lenses ◽  
Delivery Systems ◽  
Ocular Drug Delivery ◽  
Ocular Tissue ◽  
Soft Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
New Therapeutic Approaches ◽  
Ophthalmic Drug

Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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