Efficient near-infrared photosensitizer with aggregation-induced emission characteristics for mitochondria-targeted and image-guided photodynamic cancer therapy

2020 ◽  
Vol 4 (7) ◽  
pp. 2064-2071 ◽  
Author(s):  
Hanxiao Yang ◽  
Jiabao Zhuang ◽  
Nan Li ◽  
Yue Li ◽  
Shiyu Zhu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Near Infrared ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Highly Efficient ◽  
Photodynamic Cancer Therapy

A highly efficient near-infrared photosensitizer with aggregation-induced emission characteristics was developed for mitochondria-targeted and image-guided photodynamic cancer therapy.

scholarly journals Precise and Efficient Phototheranostics: Molecular Engineering of Photosensitizers with Near-Infrared Aggregation-Induced Emission for Acid-Triggered Nucleus-Targeted Photodynamic Cancer Therapy

2020 ◽  
Author(s):  
Zhijun Zhang ◽  
Wenhan XU ◽  
Peihong Xiao ◽  
Miaomiao Kang ◽  
Dingyuan Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Molecular Engineering ◽  
Ros Generation ◽  
Subcellular Targeting ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Phototheranostics involving both fluorescence imaging (FLI) and photodynamic therapy (PDT) has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal towards practical applications, owing to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory theranostics delivery. In this contribution, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers having aggregation-induced emission (AIE) features and well tailored nanocarrier system. The yielded AIE NPs simultaneously exhibit broad absorption in visible light region, bright near-infrared fluorescence emission, extremely high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them dramatically promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic system bearing excellent photostability and appreciable biosecurity well performed in FLI-guided photodynamic cancer therapy. This study thus not only extends the applications scope of AIE nanomaterials, but also offers useful insights into constructing a new generation of cancer theranostics.

scholarly journals Long wavelength excitable near-infrared fluorescent nanoparticles with aggregation-induced emission characteristics for image-guided tumor resection

2017 ◽  
Vol 8 (4) ◽  
pp. 2782-2789 ◽  
Author(s):  
Jie Liu ◽  
Chao Chen ◽  
Shenglu Ji ◽  
Qian Liu ◽  
Dan Ding ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Resection ◽  
Tumor Detection ◽  
Fluorescent Nanoparticles ◽  
Emission Characteristics ◽  
Aggregation Induced Emission ◽  
Long Wavelength ◽  
Image Guided ◽  
Fluorescent Molecules

Two series of long wavelength excitable near infrared (NIR) fluorescent molecules with aggregation-induced emission characteristics are developed to prepare NIR AIE nanoparticles for accurate tumor detection and image-guided tumor resection.

A Highly Efficient and Photostable Photosensitizer with Near-Infrared Aggregation-Induced Emission for Image-Guided Photodynamic Anticancer Therapy

2017 ◽  
Vol 29 (33) ◽  
pp. 1700548 ◽  
Author(s):  
Wenbo Wu ◽  
Duo Mao ◽  
Fang Hu ◽  
Shidang Xu ◽  
Chao Chen ◽  
...  
Keyword(s):  
Near Infrared ◽  
Anticancer Therapy ◽  
Aggregation Induced Emission ◽  
Image Guided ◽  
Highly Efficient

scholarly journals Precise and Efficient Phototheranostics: Molecular Engineering of Photosensitizers with Near-Infrared Aggregation-Induced Emission for Acid-Triggered Nucleus-Targeted Photodynamic Cancer Therapy

2020 ◽  
Author(s):  
Zhijun Zhang ◽  
Wenhan XU ◽  
Peihong Xiao ◽  
Miaomiao Kang ◽  
Dingyuan Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Molecular Engineering ◽  
Ros Generation ◽  
Subcellular Targeting ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Phototheranostics involving both fluorescence imaging (FLI) and photodynamic therapy (PDT) has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal towards practical applications, owing to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory theranostics delivery. In this contribution, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers having aggregation-induced emission (AIE) features and well tailored nanocarrier system. The yielded AIE NPs simultaneously exhibit broad absorption in visible light region, bright near-infrared fluorescence emission, extremely high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them dramatically promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic system bearing excellent photostability and appreciable biosecurity well performed in FLI-guided photodynamic cancer therapy. This study thus not only extends the applications scope of AIE nanomaterials, but also offers useful insights into constructing a new generation of cancer theranostics.

scholarly journals Precise and Efficient Phototheranostics: Molecular Engineering of Photosensitizers with Near-Infrared Aggregation-Induced Emission for Acid-Triggered Nucleus-Targeted Photodynamic Cancer Therapy

2020 ◽  
Author(s):  
Zhijun Zhang ◽  
Wenhan XU ◽  
Peihong Xiao ◽  
Miaomiao Kang ◽  
Dingyuan Yan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Fluorescence Emission ◽  
Molecular Engineering ◽  
Ros Generation ◽  
Subcellular Targeting ◽  
Aggregation Induced Emission ◽  
Photodynamic Cancer Therapy

Phototheranostics involving both fluorescence imaging (FLI) and photodynamic therapy (PDT) has been recognized to be potentially powerful for cancer treatment by virtue of various intrinsic advantages. However, the state-of-the-art materials in this area are still far from ideal towards practical applications, owing to their respective and collective drawbacks, such as inefficient imaging quality, inferior reactive oxygen species (ROS) production, the lack of subcellular-targeting capability, and dissatisfactory theranostics delivery. In this contribution, these shortcomings are successfully addressed through the integration of finely engineered photosensitizers having aggregation-induced emission (AIE) features and well tailored nanocarrier system. The yielded AIE NPs simultaneously exhibit broad absorption in visible light region, bright near-infrared fluorescence emission, extremely high ROS generation, as well as tumor lysosomal acidity-activated and nucleus-targeted delivery functions, making them dramatically promising for precise and efficient phototheranostics. Both in vitro and in vivo evaluations show that the presented nanotheranostic system bearing excellent photostability and appreciable biosecurity well performed in FLI-guided photodynamic cancer therapy. This study thus not only extends the applications scope of AIE nanomaterials, but also offers useful insights into constructing a new generation of cancer theranostics.

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