Rational design of near-infrared platinum(ii)-acetylide conjugated polymers for photoacoustic imaging-guided synergistic phototherapy under 808 nm irradiation

We have developed a novel near-infrared Pt-acetylide conjugated polymer CP3 with highly efficient photoconversion behaviors for synergistic cancer phototherapy.

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Side-chain engineering of conjugated polymers toward highly efficient near-infrared organic photo-detectors via morphology and dark current management

Journal of Materials Chemistry C ◽

10.1039/d0tc00082e ◽

2020 ◽

Vol 8 (23) ◽

pp. 7765-7771

Author(s):

Yeongkwon Kang ◽

Hyeong Ju Eun ◽

Hyojin Kye ◽

Dahee Kim ◽

Junseok Heo ◽

...

Keyword(s):

Conjugated Polymers ◽

Dark Current ◽

Conjugated Polymer ◽

Near Infrared ◽

Side Chain ◽

Current Management ◽

Highly Efficient ◽

Photo Detectors

A side-chain engineered conjugated polymer provides outstanding NIR detectivity exceeding 2.0 × 1012Jones, due to enhanced photo-responsivity and suppressed dark current.

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Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window

Materials Horizons ◽

10.1039/c7mh00672a ◽

2017 ◽

Vol 4 (6) ◽

pp. 1151-1156 ◽

Cited By ~ 66

Author(s):

Bing Guo ◽

Zonghai Sheng ◽

Kenry Kenry ◽

Dehong Hu ◽

Xiangwei Lin ◽

...

Keyword(s):

Brain Tumors ◽

Conjugated Polymer ◽

Near Infrared ◽

Photoacoustic Imaging ◽

Polymer Nanoparticles ◽

High Signal ◽

Highly Efficient ◽

Conjugated Polymer Nanoparticles ◽

Good Penetration ◽

Good Biocompatibility

NIR II conjugated polymer nanoparticles with good biocompatibility, excellent photoacoustic stability and high imaging contrast are formulated, which allows highly efficient imaging of orthotopic brain tumors with a high signal/background ratio and a good penetration depth.

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Ambient Oxygen-Doped Conjugated Polymer for pH-Activatable Aggregation-Enhanced Photoacoustic Imaging in the Second Near-Infrared Window

Analytical Chemistry ◽

10.1021/acs.analchem.0c04601 ◽

2021 ◽

Vol 93 (6) ◽

pp. 3189-3195

Author(s):

Jiayingzi Wu ◽

Liyan You ◽

Saadia T. Chaudhry ◽

Jiazhi He ◽

Ji-Xin Cheng ◽

...

Keyword(s):

Conjugated Polymer ◽

Near Infrared ◽

Photoacoustic Imaging ◽

Ambient Oxygen ◽

Infrared Window

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Selective reaction of conjugated polymers with basic proteins for broad-spectrum antivirulence therapy

NPG Asia Materials ◽

10.1038/s41427-020-00252-1 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Han Sun ◽

Jing Liu ◽

Fengting Lv ◽

Libing Liu ◽

Qi Gu ◽

...

Keyword(s):

Survival Rate ◽

Mouse Model ◽

Conjugated Polymers ◽

Broad Spectrum ◽

Conjugated Polymer ◽

Bacterial Infections ◽

Rational Design ◽

High Efficiency ◽

Broad Applicability ◽

Selective Reaction

AbstractAntivirulence therapy has proven to be an attractive method for the treatment of bacterial infections and venomous injuries; however, the approaches for neutralizing multiple types of virulence through one platform are limited. To address this challenge, we have developed a reactive conjugated polymer, PPV–NHS, which functions as a broad-spectrum antidote for directly inactivating basic toxins. The antivirulence is achieved via multivalent electrostatic recognition and subsequent amidation reactions between PPV–NHS and toxins. The resultant bioconjugates significantly reduced neurotoxicity and cytotoxicity. In the mouse model, PPV–NHS effectively inhibited the toxicity of cardiotoxin (CTX) and improved the survival rate of toxin-challenged mice. This work represents the rational design of functionalized conjugated polymers for antivirulence therapy with both high efficiency and broad applicability.

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Correction: Side-chain engineering of conjugated polymers toward highly efficient near-infrared organic photo-detectors via morphology and dark current management

Journal of Materials Chemistry C ◽

10.1039/d0tc90140g ◽

2020 ◽

Vol 8 (28) ◽

pp. 9775-9775

Author(s):

Yeongkwon Kang ◽

Hyeong Ju Eun ◽

Hyojin Kye ◽

Dahee Kim ◽

Junseok Heo ◽

...

Keyword(s):

Conjugated Polymers ◽

Dark Current ◽

Near Infrared ◽

Side Chain ◽

Current Management ◽

Highly Efficient ◽

Photo Detectors

Correction for ‘Side-chain engineering of conjugated polymers toward highly efficient near-infrared organic photo-detectors via morphology and dark current management’ by Yeongkwon Kang et al., J. Mater. Chem. C, 2020, 8, 7765–7771, DOI: 10.1039/D0TC00082E.

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Molecular engineering of diketopyrrolopyrrole-conjugated polymer nanoparticles by chalcogenide variation for photoacoustic imaging guided photothermal therapy

Journal of Materials Chemistry B ◽

10.1039/d1tb00193k ◽

2021 ◽

Vol 9 (14) ◽

pp. 3153-3160

Author(s):

Xin Jin ◽

Xiaoyi Xing ◽

Qingyuan Deng ◽

Weixia Qing ◽

Zhonghua Liu ◽

...

Keyword(s):

Conjugated Polymers ◽

Efficient Method ◽

Conjugated Polymer ◽

Photothermal Therapy ◽

Photoacoustic Imaging ◽

Molecular Engineering ◽

Polymer Nanoparticles ◽

Conjugated Polymer Nanoparticles ◽

Molecular Skeleton

This work presents an efficient method of accessing DPP-SO that not only possess an excellent anti-tumour property but also regulates the photothermal performance of DPP-conjugated polymers by changing the heteroatom in the molecular skeleton.

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