scholarly journals Injectable Silanized Hyaluronic Acid Hydrogel/Biphasic Calcium Phosphate Granule Composites with Improved Handling and Biodegradability Promote Bone Regeneration in Rabbits

2021 ◽  
Author(s):  
Killian Flegeau ◽  
Olivier Gauthier ◽  
Gildas Rethore ◽  
Florent Autrusseau ◽  
Aurelie Schaefer ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Bone Reconstruction ◽  
Hyaluronic Acid Hydrogel

Biphasic calcium phosphate (BCP) granules are osteoconductive biomaterials used in clinics to favor bone reconstruction. Yet, poor cohesivity, injectability and mechanical properties restrain their use as bone fillers. In this...

Bone regeneration of multichannel biphasic calcium phosphate granules supplemented with hyaluronic acid

2019 ◽  
Vol 99 ◽  
pp. 1058-1066 ◽  
Author(s):  
Mirana Taz ◽  
Preeti Makkar ◽  
Khan Mohammad Imran ◽  
D.W. Jang ◽  
Yong-Sik Kim ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate

scholarly journals A Combination of Biphasic Calcium Phosphate (Maxresorb®) and Hyaluronic Acid Gel (Hyadent®) for Repairing Osseous Defects in a Rat Model

2020 ◽  
Vol 10 (5) ◽  
pp. 1651 ◽  
Author(s):  
Abeer G. Ahmed ◽  
Fatin A. Awartani ◽  
Abdurahman A. Niazy ◽  
John A. Jansen ◽  
Hamdan S. Alghamdi
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Rat Model ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Group I ◽  
Male Wistar Rats ◽  
Osseous Defects

The aim of this in vivo study was to evaluate the efficacy of biphasic calcium phosphate (Maxresorb®, BCP) used in combination with hyaluronic acid (Hyadent®, HyA) gel for regeneration of osseous defects in a rat model. Bilateral femoral condylar bone defects (3 mm diameter and 3 mm depth) were created in 40 male Wistar rats. The defects were grafted as group I (BCP only), group II (BCP + HyA), group III (HyA only), and group IV (empty control). At four weeks and 10 weeks, the bone specimens were evaluated using histological and histomorphometrical analyses to identify the newly formed bone area (NF-BA (%)), as well as the remaining BCP particles (R-BCP (%)). Light microscopic examination indicated the absence of an inflammatory reaction within the bone defects after four weeks or 10 weeks of implantation. Significant new bone regeneration was present in the bone defects grafted with BCP or BCP + HyA biomaterials, as early as four weeks, compared to control groups. The addition of HyA to BCP did not significantly improve bone regeneration at four weeks or 10 weeks. Nevertheless, its role in bone healing and regeneration warrants further investigation.

A hybrid composite system of biphasic calcium phosphate granules loaded with hyaluronic acid–gelatin hydrogel for bone regeneration

2017 ◽  
Vol 32 (4) ◽  
pp. 433-445 ◽  
Author(s):  
Omar Faruq ◽  
Boram Kim ◽  
Andrew R Padalhin ◽  
Gun Hee Lee ◽  
Byong-Taek Lee
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Hybrid Composite ◽  
Biphasic Calcium Phosphate ◽  
Composite System ◽  
Gelatin Hydrogel

Development of an Injectable Calcium Phosphate/Hyaluronic Acid Microparticles System for Platelet Lysate Sustained Delivery Aiming Bone Regeneration

2016 ◽  
Vol 16 (11) ◽  
pp. 1662-1677 ◽  
Author(s):  
Pedro S. Babo ◽  
Vítor E. Santo ◽  
Manuela E. Gomes ◽  
Rui L. Reis
Keyword(s):  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Platelet Lysate ◽  
Sustained Delivery

The Fabricated Collagen-Based Nano-Hydroxyapatite/β-Tricalcium Phosphate Scaffolds

2012 ◽  
Vol 506 ◽  
pp. 57-60 ◽  
Author(s):  
M. Ebrahimi ◽  
Naruporn Monmaturapoj ◽  
S. Suttapreyasri ◽  
P. Pripatnanont
Keyword(s):  
Mechanical Properties ◽  
Solid State ◽  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Single Phase ◽  
Physical And Mechanical Properties ◽  
Total Porosity ◽  
Xrd Pattern ◽  
Collagen Coating ◽  
Dimensional Shrinkage

The biphasic calcium phosphate (BCP) concept was introduced to overcome disadvantages of single phase biomaterials. In this study, we prepared BCP from nanoHA and β-TCP that were synthesized via a solid state reaction. Three different ratios of pure BCP and collagen-based BCP scaffolds (%HA/%β-TCP; 30/70, 40/60 and 50/50) were produced using a polymeric sponge method. Physical and mechanical properties of all materials and scaffolds were investigated. XRD pattern proved the purity of each HA, β-TCP and BCP. SEM showed overall distribution of macropores (80-200 µm) with appropriate interconnected porosities. Total porosity of pure BCP (93% ± 2) was found to be higher than collagen-based BCP (85%± 3). It was observed that dimensional shrinkage of larger scaffold (39% ± 4) is lower than smaller one (42% ± 5) and scaffolds with higher HA (50%) ratio experienced greater shrinkage than those with higher β-TCP (70%) ratio (45% ±3 and 36% ±1 respectively). Mechanical properties of both groups tend to be very low and collagen coating had no influence on mechanical behavior. Further studies may improve the physical properties of these composite BCP.

scholarly journals Distinctive bone regeneration of calvarial defects using biphasic calcium phosphate supplemented ultraviolet-crosslinked collagen membrane

2020 ◽  
Vol 50 (1) ◽  
pp. 14 ◽  
Author(s):  
Inpyo Hong ◽  
Alharthi Waleed Khalid ◽  
Hyung-Chul Pae ◽  
Jae-Kook Cha ◽  
Jung-Seok Lee ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Biphasic Calcium Phosphate ◽  
Collagen Membrane ◽  
Calvarial Defects
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