Therapeutic effects of boronate ester cross-linked injectable hydrogels for the treatment of hepatocellular carcinoma

2021 ◽  
Author(s):  
Jae Min Jung ◽  
Seong Han Kim ◽  
V. H. Giang Phan ◽  
Thavasyappan Thambi ◽  
Doo Sung Lee
Keyword(s):  
Hepatocellular Carcinoma ◽  
Ethylene Glycol ◽  
Therapeutic Effects ◽  
Poly Ethylene Glycol ◽  
Injectable Hydrogels ◽  
High Incidence ◽  
High Incidence Rate ◽  
The Common ◽  
Poly Ethylene ◽  
Responsive Hydrogels

Hepatocellular carcinoma is the common malignant with a high incidence rate and responsible for the highest cause of cancer-related deaths. Herein, we developed a thermo-responsive hydrogels comprised of poly(ε-caprolactone-co-lactide)-b-poly(ethylene glycol)-b-poly(ε-caprolactone-co-lactide...

Best of both worlds: Diels–Alder chemistry towards fabrication of redox-responsive degradable hydrogels for protein release

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74757-74764 ◽  
Author(s):  
Ismail Altinbasak ◽  
Rana Sanyal ◽  
Amitav Sanyal
Keyword(s):  
Ethylene Glycol ◽  
Alder Reaction ◽  
Diels Alder ◽  
Protein Release ◽  
Poly Ethylene Glycol ◽  
Diels Alder Reaction ◽  
Redox Responsive ◽  
Poly Ethylene ◽  
Responsive Hydrogels

Poly(ethylene glycol)-based redox-responsive hydrogels have been preparedviathe Diels–Alder reaction between a furan-containing hydrophilic copolymer and a disulfide-containing bis-maleimide based crosslinker.

Thermo-Responsive Hydrogels Based on Branched Poly(L-lactide)-poly(ethylene glycol) Copolymers

2008 ◽  
Vol 272 (1) ◽  
pp. 13-27 ◽  
Author(s):  
Ingrid W. Velthoen ◽  
Edze J. Tijsma ◽  
Pieter J. Dijkstra ◽  
Jan Feijen
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Responsive Hydrogels

Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials

RSC Advances ◽  
2015 ◽  
Vol 5 (45) ◽  
pp. 35469-35486 ◽  
Author(s):  
Emilia Bakaic ◽  
Niels M. B. Smeets ◽  
Todd Hoare
Keyword(s):  
Ethylene Glycol ◽  
Recent Progress ◽  
Design Criteria ◽  
Poly Ethylene Glycol ◽  
Injectable Hydrogels ◽  
Glycol Methacrylate ◽  
Oligoethylene Glycol ◽  
Poly Ethylene ◽  
Functional Biomaterials

The design criteria for injectable, in situ-gelling hydrogels are reviewed in conjunction with highlights on recent progress in the preparation of injectable PEG and PEG-analogue poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels.

Enzyme-mediated preparation of hydrogels composed of poly(ethylene glycol) and gelatin as cell culture platforms

RSC Advances ◽  
2015 ◽  
Vol 5 (4) ◽  
pp. 3070-3073 ◽  
Author(s):  
Kousuke Moriyama ◽  
Rie Wakabayashi ◽  
Masahiro Goto ◽  
Noriho Kamiya
Keyword(s):  
Cell Culture ◽  
Horseradish Peroxidase ◽  
Ethylene Glycol ◽  
Cell Sheet ◽  
Viable Cell ◽  
Poly Ethylene Glycol ◽  
Redox Responsive ◽  
Poly Ethylene ◽  
Responsive Hydrogels

Horseradish peroxidase-mediated preparation of redox-responsive hydrogels composed of thiolated poly(ethylene glycol) and gelatin allowed the proliferation of cells on the gel and the harvest as a viable cell sheet.

Poly(ethylene glycol)–poly(lysine) block copolymer–ubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells

Oncogene ◽  
2018 ◽  
Vol 38 (2) ◽  
pp. 244-260 ◽  
Author(s):  
Reishi Toshiyama ◽  
Masamitsu Konno ◽  
Hidetoshi Eguchi ◽  
Hiroyasu Takemoto ◽  
Takehiro Noda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Antitumor Effect ◽  
Aminopeptidase N ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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