Indentification of Mitochondria-related Hub Genes in Sarcopenia and Functional Regulation of MFG-E8 on ROS-mediated Mitochondrial Dysfunction and Cell Cycle Arrest

Sarcopenia has a high prevalence in the elderly population, but the genes and pathways related to aging in elderly patients with sarcopenia are poorly understood. Milk fat globule epidermal growth...

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Milk fat globule-epidermal growth factor 8 is a critical determinant of bone mass and alters the course of inflammation in arthritis

Bone Abstracts ◽

10.1530/boneabs.1.pp18 ◽

2013 ◽

Author(s):

Kathrin Sinningen ◽

Sylvia Thiele ◽

Sylvia Grossklaus ◽

Mark Udey ◽

Hofbauer Lorenz C ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Bone Mass ◽

Milk Fat ◽

Critical Determinant ◽

Milk Fat Globule ◽

Epidermal Growth ◽

Fat Globule

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Loss of milk fat globule-epidermal growth factor 8 (MFG-E8) in mice leads to low bone mass and accelerates ovariectomy-associated bone loss by increasing osteoclastogenesis

Bone ◽

10.1016/j.bone.2015.04.003 ◽

2015 ◽

Vol 76 ◽

pp. 107-114 ◽

Cited By ~ 8

Author(s):

Kathrin Sinningen ◽

Elise Albus ◽

Sylvia Thiele ◽

Sylvia Grossklaus ◽

Thomas Kurth ◽

...

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Bone Loss ◽

Bone Mass ◽

Milk Fat ◽

Low Bone Mass ◽

Milk Fat Globule ◽

Epidermal Growth ◽

Fat Globule

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Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury

Journal of Surgical Research ◽

10.1016/j.jss.2017.02.024 ◽

2017 ◽

Vol 213 ◽

pp. 281-289 ◽

Cited By ~ 4

Author(s):

Cindy Cen ◽

Monowar Aziz ◽

Weng-Lang Yang ◽

Mian Zhou ◽

Jeffrey M. Nicastro ◽

...

Keyword(s):

Acute Kidney Injury ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Factor Viii ◽

Milk Fat ◽

Kidney Injury ◽

Milk Fat Globule ◽

Epidermal Growth ◽

Fat Globule

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TGF-β Increases MFGE8 Production in Myeloid-Derived Suppressor Cells to Promote B16F10 Melanoma Metastasis

Biomedicines ◽

10.3390/biomedicines9080896 ◽

2021 ◽

Vol 9 (8) ◽

pp. 896

Author(s):

Heejin Lim ◽

Taewoo Yang ◽

Wongeun Lee ◽

Sung-Gyoo Park

Keyword(s):

Milk Fat ◽

Tumor Metastasis ◽

Suppressor Cells ◽

Melanoma Metastasis ◽

Myeloid Derived Suppressor Cells ◽

B16f10 Melanoma ◽

B16f10 Cell ◽

Milk Fat Globule ◽

Epidermal Growth ◽

Fat Globule

There is growing evidence that myeloid-derived suppressor cells (MDSCs) are directly involved in all stages leading to metastasis. Many mechanisms for this effect have been proposed, but mechanisms of coregulation between tumor cells and MDSCs remain poorly understood. In this study, we demonstrate that MDSCs are a source of milk fat globule-epidermal growth factor (EGF) factor 8 (MFGE8), which is known to be involved in tumor metastasis. Interestingly, TGF-β, an abundant cytokine in the tumor microenvironment (TME), increased MFGE8 production by MDSCs. In addition, co-culturing MDSCs with B16F10 melanoma cells increased B16F10 cell migration, while MFGE8 neutralization decreased their migration. Taken together, these findings suggest that MFGE8 is an important effector molecule through which MDSCs promote tumor metastasis, and the TME positively regulates MFGE8 production by MDSCs through TGF-β.

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