Gamma rays as innovative tool towards synthesizing conducting copolymers with improved properties

New Journal of Chemistry ◽

10.1039/d1nj02300d ◽

2021 ◽

Author(s):

Teseer Bahry ◽

Benazir Khurshid ◽

Yamina Chouli ◽

Souad Abou Zeid ◽

Cyrille sollogoub ◽

...

Keyword(s):

Gamma Rays ◽

Water Radiolysis ◽

Innovative Tool ◽

Conducting Copolymers ◽

Thiophene Derivatives

In the present study, copolymers of Pyrrole (Py) with different co-monomers (thiophene derivatives) were originally polymerized through two radiolytic approaches: water radiolysis and dichloromethane radiolysis. This method can be easily...

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A Facile One-Pot Synthesis of Versatile PEGylated Platinum Nanoflowers and Their Application in Radiation Therapy

International Journal of Molecular Sciences ◽

10.3390/ijms21051619 ◽

2020 ◽

Vol 21 (5) ◽

pp. 1619 ◽

Cited By ~ 1

Author(s):

Xiaomin Yang ◽

Daniela Salado-Leza ◽

Erika Porcel ◽

César R. González-Vargas ◽

Farah Savina ◽

...

Keyword(s):

Radiation Therapy ◽

Gamma Rays ◽

Metallic Nanoparticles ◽

Large Scale ◽

Molecular Probe ◽

Water Radiolysis ◽

Fluorescence Lifetime Imaging ◽

One Pot ◽

Fluorescent Markers ◽

Cervical Cancer Cells

Nanomedicine has stepped into the spotlight of radiation therapy over the last two decades. Nanoparticles (NPs), especially metallic NPs, can potentiate radiotherapy by specific accumulation into tumors, thus enhancing the efficacy while alleviating the toxicity of radiotherapy. Water radiolysis is a simple, fast and environmentally-friendly method to prepare highly controllable metallic nanoparticles in large scale. In this study, we used this method to prepare biocompatible PEGylated (with Poly(Ethylene Glycol) diamine) platinum nanoflowers (Pt NFs). These nanoagents provide unique surface chemistry, which allows functionalization with various molecules such as fluorescent markers, drugs or radionuclides. The Pt NFs were produced with a controlled aggregation of small Pt subunits through a combination of grafted polymers and radiation-induced polymer cross-linking. Confocal microscopy and fluorescence lifetime imaging microscopy revealed that Pt NFs were localized in the cytoplasm of cervical cancer cells (HeLa) but not in the nucleus. Clonogenic assays revealed that Pt NFs amplify the gamma rays induced killing of HeLa cells with a sensitizing enhancement ratio (SER) of 23%, thus making them promising candidates for future cancer radiation therapy. Furthermore, the efficiency of Pt NFs to induce nanoscopic biomolecular damage by interacting with gamma rays, was evaluated using plasmids as molecular probe. These findings show that the Pt NFs are efficient nano-radio-enhancers. Finally, these NFs could be used to improve not only the performances of radiation therapy treatments but also drug delivery and/or diagnosis when functionalized with various molecules.

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Synthesis and Characterization of Conducting Copolymers of Thiophene Derivatives

Journal of Macromolecular Science Part A ◽

10.1080/10601325.2014.871949 ◽

2014 ◽

Vol 51 (3) ◽

pp. 210-216 ◽

Cited By ~ 5

Author(s):

Ersen Turac ◽

Ertugrul Sahmetlioglu ◽

Levent Toppare

Keyword(s):

Synthesis And Characterization ◽

Conducting Copolymers ◽

Thiophene Derivatives

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On the possible gamma-ray source in Cygnus

Symposium - International Astronomical Union ◽

10.1017/s0074180900101391 ◽

1967 ◽

Vol 31 ◽

pp. 469-471

Author(s):

J. G. Duthie ◽

M. P. Savedoff ◽

R. Cobb

Keyword(s):

Gamma Rays ◽

Gamma Ray ◽

Right Ascension

A source of gamma rays has been found at right ascension 20h15m, declination +35°, with an uncertainty of 6° in each coordinate. Its flux is (1·5 ± 0·8) x 10-4photons cm-2sec-1at 100 MeV. Possible identifications are reviewed, but no conclusion is reached. The mechanism producing the radiation is also uncertain.

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Solar Flare Energetic Neutral Emission Measurements in the Project Coronas-I

International Astronomical Union Colloquium ◽

10.1017/s0252921100026208 ◽

1994 ◽

Vol 144 ◽

pp. 635-639

Author(s):

J. Baláž ◽

A. V. Dmitriev ◽

M. A. Kovalevskaya ◽

K. Kudela ◽

S. N. Kuznetsov ◽

...

Keyword(s):

Solar Flare ◽

Energy Range ◽

Gamma Rays ◽

Pulse Shape ◽

Gamma Ray ◽

Pulse Shape Discrimination ◽

Shape Discrimination ◽

Solar Neutron ◽

Low Altitude

AbstractThe experiment SONG (SOlar Neutron and Gamma rays) for the low altitude satellite CORONAS-I is described. The instrument is capable to provide gamma-ray line and continuum detection in the energy range 0.1 – 100 MeV as well as detection of neutrons with energies above 30 MeV. As a by-product, the electrons in the range 11 – 108 MeV will be measured too. The pulse shape discrimination technique (PSD) is used.

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Ovarian Dysfunction in Fetally Irradiated Beagles

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100080717 ◽

1977 ◽

Vol 35 ◽

pp. 658-659

Author(s):

T. M. Seed ◽

M. H. Sanderson ◽

D. L. Gutzeit ◽

T. E. Fritz ◽

D. V. Tolle ◽

...

Keyword(s):

Gamma Rays ◽

Low Dose ◽

Long Term Effects ◽

Ovarian Dysfunction ◽

Dose Rates ◽

Highly Sensitive ◽

Microscopic Evaluation ◽

Ovarian Pathology ◽

Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

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