SYNTHESIS, CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF NEW 1,3-DIMETHYL-8-(CHROMON-3-YL)-XANTHINE DERIVATIVES CONTAINING 2,6-DI-TERT-BUTYLPHENOL FRAGMENT

2021 ◽  
Author(s):  
Stanislav S. Shatokhin ◽  
Vladislav A Tuskaev ◽  
Svetlana Chermenovna Gagieva ◽  
Alina Markova ◽  
Dmitry I. Pozdnyakov ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Tert Butyl ◽  
Xanthine Derivatives ◽  
Sterically Hindered Phenol ◽  
Hindered Phenol ◽  
Sterically Hindered

The condensation of 3-formylchromones and 6-amino-5-((3,5-di-tert-butyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino)-1,3-dimethyl-pyrimidine-2,4(1H,3H)-dione allowed us to synthesize chromone based hybrids containing additional pharmacophores - xanthine and sterically hindered phenol fragments. Novel compounds have been characterized by 1H...

2,6-Di-tert-butyl-4-{[N-(4,6-dichloro-1,3,5-triazin-2-yl)propylamino]methyl}phenol

2006 ◽  
Vol 62 (7) ◽  
pp. o2916-o2917 ◽  
Author(s):  
Tao Zeng ◽  
Li-Gong Chen
Keyword(s):  
Dihedral Angle ◽  
Title Compound ◽  
Phenol Group ◽  
Tert Butyl ◽  
Compound C ◽  
Sterically Hindered Phenol ◽  
Hindered Phenol ◽  
Sterically Hindered

The title compound, C21H30Cl2N4O, contains a sterically hindered phenol group. The dihedral angle between the two rings is 72.3 (1)°. The propyl chain is disordered over two orientations.

Antioxidant activity of isatin acylhydrazones with sterically hindered phenol fragments

2015 ◽  
Vol 85 (1) ◽  
pp. 53-56 ◽  
Author(s):  
G. N. Nugumanova ◽  
S. V. Bukharov ◽  
R. G. Tagasheva ◽  
N. A. Mukmeneva ◽  
R. Ya. Deberdeev
Keyword(s):  
Antioxidant Activity ◽  
Sterically Hindered Phenol ◽  
Hindered Phenol ◽  
Sterically Hindered

scholarly journals Antioxidant activity of thiophane in rats with of experimental tetrachlorolmethane-induced hepatitis

2010 ◽  
Vol 9 (5) ◽  
pp. 98-101
Author(s):  
V. I. Smoliyakova ◽  
M. B. Plotnikov ◽  
G. A. Chernyshyova ◽  
I. S. Ivanov ◽  
A. Ye. Prosenko ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Tocopherol Content ◽  
Intragastric Administration ◽  
Lipid Peroxidation Products ◽  
Sterically Hindered Phenol ◽  
Fluorescent Products ◽  
Hindered Phenol ◽  
Sterically Hindered

The purpose of this investigation is to study antioxidant activity of sterically hindered phenol — thiophane in rats with toxical hepatitis. Increase of diene and triene conjugates as well as fluorescent products in hepar tissue was revealed. Course intragastric administration of thiophane decreased significantly the content of lipid peroxidation products (diene and triene conjugates, fluorescent products) and held over the α-tocopherol content in hepar tissue.

Synthesis and Antioxidant Activity of Sterically Hindered Phenol Derivatives of Carboxy- and Sulfobetaines

2018 ◽  
Vol 88 (1) ◽  
pp. 68-72 ◽  
Author(s):  
R. G. Tagasheva ◽  
E. R. Shakirova ◽  
S. V. Bukharov ◽  
I. V. Galkina ◽  
G. K. Ziyatdinova ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Phenol Derivatives ◽  
Sterically Hindered Phenol ◽  
Hindered Phenol ◽  
Sterically Hindered ◽  
Derivatives Of

Antioxidant activity of hydrazones with sterically hindered phenol fragments

2012 ◽  
Vol 86 (12) ◽  
pp. 1816-1820 ◽  
Author(s):  
A. N. Nikolaevskii ◽  
O. P. Kniga ◽  
E. I. Khizhan ◽  
G. A. Tikhonova ◽  
V. V. Vinogradov ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Sterically Hindered Phenol ◽  
Hindered Phenol ◽  
Sterically Hindered

Crystal and Molecular Structural Features of Indolin-2-One Derivatives with Sterically Hindered Phenol Moieties

2018 ◽  
Vol 59 (2) ◽  
pp. 439-448
Author(s):  
E. V. Mironova ◽  
A. V. Bogdanov ◽  
G. N. Nugumanova ◽  
S. V. Bukharov ◽  
V. F. Mironov ◽  
...  
Keyword(s):  
Structural Features ◽  
Sterically Hindered Phenol ◽  
Hindered Phenol ◽  
Sterically Hindered

Bi-functional sterically hindered phenol lipid-based delivery systems as potential multi-target agents against Alzheimer's disease via an intranasal route

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13757-13770
Author(s):  
Evgenia A. Burilova ◽  
Tatiana N. Pashirova ◽  
Irina V. Zueva ◽  
Elmira M. Gibadullina ◽  
Sofya V. Lushchekina ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Intranasal Administration ◽  
Delivery Systems ◽  
Sterically Hindered Phenols ◽  
Intranasal Route ◽  
Sterically Hindered Phenol ◽  
Hindered Phenols ◽  
Hindered Phenol ◽  
Sterically Hindered

New lipid-based nanomaterials based on sterically hindered phenols were developed as potential drugs against Alzheimer's disease via intranasal administration.

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