Synthesis and biological evaluation of isatin oxime ether-tethered aryl 1H-1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis

2022 ◽  
Author(s):  
Sampath Kumar Kancharla ◽  
Saritha Birudaraju ◽  
Arani Pal ◽  
L. Krishnakanth Reddy ◽  
RAMI REDDY EDA ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Evaluation ◽  
Oxime Ether ◽  
Propargyl Ether ◽  
Synthesis And Biological Evaluation

A series of fifteen novel isatin oxime ether-tethered aryl 1H-1,2,3-triazole hybrids 5a-o were designed and synthesized by employing Cu(I) catalyzed azide-alkyne [3+2] cycloaddition (CuAAC) between isatin oxime O-propargyl ether and...

Pyranocoumarin, a novel anti-TB pharmacophore: Synthesis and biological evaluation against Mycobacterium tuberculosis

2006 ◽  
Vol 14 (13) ◽  
pp. 4610-4626 ◽  
Author(s):  
Ze-Qi Xu ◽  
Krzysztof Pupek ◽  
William J. Suling ◽  
Livia Enache ◽  
Michael T. Flavin
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis and Biological Evaluation of New Hydrazone Derivatives of Quinoline and Their Cu(II) and Zn(II) Complexes againstMycobacterium tuberculosis

2015 ◽  
Vol 2015 ◽  
pp. 1-14 ◽  
Author(s):  
Mustapha C. Mandewale ◽  
Bapu Thorat ◽  
Dnyaneshwar Shelke ◽  
Ramesh Yamgar
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Metal Complexes ◽  
Inhibitory Activity ◽  
Biological Properties ◽  
Biological Evaluation ◽  
Fluorescence Properties ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A new series of quinoline hydrazone derivatives and their metal complexes have been synthesized and their biological properties have been evaluated againstMycobacterium tuberculosis(H37 RV strain). Most of the newly synthesized compounds displayed 100% inhibitory activity at a concentration of 6.25–25 μg/mL, againstMycobacterium tuberculosis. Fluorescence properties of all the synthesized compounds have been studied.

scholarly journals The synthesis and biological evaluation of mycobacterial p-hydroxybenzoic acid derivatives (p-HBADs)

2014 ◽  
Vol 12 (7) ◽  
pp. 1114-1123 ◽  
Author(s):  
Jean Bourke ◽  
Corinna F. Brereton ◽  
Stephen V. Gordon ◽  
Ed C. Lavelle ◽  
Eoin M. Scanlan
Keyword(s):  
Immune Response ◽  
Mycobacterium Tuberculosis ◽  
Host Immune Response ◽  
Biological Evaluation ◽  
Hydroxybenzoic Acid ◽  
Synthesis And Biological Evaluation

Synthetic p-hydroxybenzoic acid derivatives (p-HBADs) from Mycobacterium tuberculosis have the ability to suppress host immune response in vitro.

Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids

2016 ◽  
Vol 84 ◽  
pp. 1739-1747 ◽  
Author(s):  
Dijovani Batista dos Reis ◽  
Thalita Cristina Alves Souza ◽  
Maria Cristina S. Lourenço ◽  
Mauro Vieira de Almeida ◽  
Adriano Barbosa ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Evaluation ◽  
Leishmania Amazonensis ◽  
Synthesis And Biological Evaluation
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