Programmable, self-assembled DNA nanodevices for cellular programming and tissue engineering

Nanoscale ◽  
2021 ◽  
Author(s):  
Ankit Gangrade ◽  
Nicholas Stephanopoulos ◽  
Dhiraj Devidas Bhatia
Keyword(s):  
Tissue Engineering ◽  
Supramolecular Chemistry ◽  
Materials Science ◽  
Dynamic Field ◽  
Self Assembled

DNA-based nanotechnology has evolved into an autonomous, highly innovative, and dynamic field of research at the nexus of supramolecular chemistry, nanotechnology, materials science, and biotechnology. DNA-based materials, including origami nanodevices,...

Mechanical basis for fibrillar bundle morphology

Soft Matter ◽  
2020 ◽  
Vol 16 (40) ◽  
pp. 9306-9318
Author(s):  
Thomas C. T. Michaels ◽  
Edvin Memet ◽  
L. Mahadevan
Keyword(s):  
Molecular Biology ◽  
Supramolecular Chemistry ◽  
Materials Science ◽  
Mechanical Basis ◽  
Self Assembled

Understanding the morphology of self-assembled fibrillar bundles and aggregates is relevant to a range of problems in molecular biology, supramolecular chemistry and materials science.

scholarly journals Synthesis and Characterization of a Bioconjugate Based on Oleic Acid and L-Cysteine

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1791
Author(s):  
Marco Vizcarra-Pacheco ◽  
María Ley-Flores ◽  
Ana Mizrahim Matrecitos-Burruel ◽  
Ricardo López-Esparza ◽  
Daniel Fernández-Quiroz ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Materials Science ◽  
Critical Micellar Concentration ◽  
Synthesis And Characterization ◽  
New Materials ◽  
Visible Spectroscopy ◽  
Amide Bonds ◽  
Transmission Electron ◽  
Self Assembled

One of the main challenges facing materials science today is the synthesis of new biodegradable and biocompatible materials capable of improving existing ones. This work focused on the synthesis of new biomaterials from the bioconjugation of oleic acid with L-cysteine using carbodiimide. The resulting reaction leads to amide bonds between the carboxylic acid of oleic acid and the primary amine of L-cysteine. The formation of the bioconjugate was corroborated by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, and nuclear magnetic resonance (NMR). In these techniques, the development of new materials with marked differences with the precursors was confirmed. Furthermore, NMR has elucidated a surfactant structure, with a hydrophilic part and a hydrophobic section. Ultraviolet-visible spectroscopy (UV-Vis) was used to determine the critical micellar concentration (CMC) of the bioconjugate. Subsequently, light diffraction (DLS) was used to analyze the size of the resulting self-assembled structures. Finally, transmission electron microscopy (TEM) was obtained, where the shape and size of the self-assembled structures were appreciated.

scholarly journals Self-assembled luminescent Cu(I) tetrametallic metallacycles based on 3,3’-bipyridine ligand

2021 ◽  
Author(s):  
Christophe Lescop ◽  
Guillaume Calvez ◽  
Florent Moutier ◽  
Jana Schiller
Keyword(s):  
Supramolecular Chemistry ◽  
Bipyridine Ligand ◽  
Self Assembled

3,3’-bipyridine ligand B was reacted with pre-assembled [Cu2(2-dppm)2] Cu(I) bimetallic flexible precursor A accordingly to coordination-driven supramolecular chemistry synthetic principles. Outcomes obtained revealed the necessity to formally introduce bridging halide...

scholarly journals Self-assembled composite matrix in a hierarchical 3-D scaffold for bone tissue engineering

2011 ◽  
Vol 7 (5) ◽  
pp. 2244-2255 ◽  
Author(s):  
Muwan Chen ◽  
Dang Q.S. Le ◽  
Anette Baatrup ◽  
Jens V. Nygaard ◽  
San Hein ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Matrix ◽  
Self Assembled

Regenerative Medicine: Applications and Development in Urology

2007 ◽  
Vol 74 (4) ◽  
pp. 197-205
Author(s):  
F. Pinto ◽  
A. Calarco ◽  
A. Brescia ◽  
E. Sacco ◽  
A. D'addessi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Regenerative Medicine ◽  
Cell Transplantation ◽  
Materials Science ◽  
Experimental Studies ◽  
Embryonic Stem ◽  
Human Embryos ◽  
Engineering Applications

Purpose Congenital abnormalities and acquired disorders can lead to organ damage and loss. Nowadays, transplantation represents the only effective treatment option. However, there is a marked decrease in the number of organ donors, which is even yearly worsening due to the population aging. The regenerative medicine represents a realistic option that allows to restore and maintain the normal functions of tissues and organs. This article reviews the principles of regenerative medicine and the recent advances with regard to its application to the genitourinary tract. Recent findings The field of regenerative medicine involves different areas of technology, such as tissue engineering, stem cells and cloning. Tissue engineering involves the field of cell transplantation, materials science and engineering in order to create functional replacement tissues. Stem cells and cloning permit the extraction of pluripotent, embryonic stem cells offering a potentially limitless source of cells for tissue engineering applications. Most current strategies for tissue engineering depend upon a sample of autologous cells from the patient's diseased organ. Biopsies from patients with extensive end-stage organ failure, however, may not yield enough normal cells. In these situations, stem cells are envisaged as being an alternative source. Stem cells can be derived from discarded human embryos (human embryonic stem cells), from fetal tissue or from adult sources (bone marrow, fat, skin). Therapeutic cloning offers a potentially limitless source of cells for tissue engineering applications. Regenerative medicine and tissue engineering scientists have increasingly applied the principles of cell transplantation, materials science and bioengineering to construct biological substitutes that will restore and maintain normal function in urological diseased and injured tissues such as kidney, ureter, bladder, urethra and penis. Conclusions Regenerative medicine offers several applications in acquired and congenital genitourinary diseases. Tissue engineering, stem cells and, mostly, cloning have been applied in experimental studies with excellent results. Few preliminary human applications have been developed with promising results.

The Application of Natural Collagen Materials and Tissue Engineering on Repair for Exercise-Induced Meniscus Injury

2013 ◽  
Vol 830 ◽  
pp. 490-494
Author(s):  
Zhi Ping Wang
Keyword(s):  
Tissue Engineering ◽  
Materials Science ◽  
Meniscus Repair ◽  
Practical Application ◽  
Tissue Engineering Scaffolds ◽  
Meniscus Injury ◽  
Meniscus Tissue ◽  
Engineering Problems ◽  
Mechanical Factors ◽  
Exercise Induced

With the development of tissue engineering and materials science, through the research of meniscus tissue engineering to discover novel tissue engineering materials, and further accelerate the research of meniscus tissue engineering, through clinical trials and application of finding appropriate meniscus substitute, which can provide a new mode of treatment for meniscus repair. The focus of the current study including the mechanism of meniscus injury can absorb the natural collagen meniscus tissue engineering scaffolds as feasibility analysis, stress stimulation, meniscus recovery mechanical factors in 4 aspects. Research shows that it has a good application prospect and wider space for meniscus tissue engineering repair of exercise-induced meniscus injury. But in practical application, the meniscus tissue engineering scaffold construction, research on extra cellular matrix composite and its tissue compatibility, repair after tissue engineering meniscus stress stimulation and can withstand the mechanical factors the problem is still the meniscus tissue engineering problems.

Materials science and design principles of therapeutic materials in orthopedic and bone tissue engineering

2021 ◽  
Author(s):  
Wenqing Liang ◽  
Yongqiang Dong ◽  
Hailiang Shen ◽  
Ruyi Shao ◽  
Xudong Wu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Materials Science ◽  
Design Principles

Self-Assembled Biomimetic Scaffolds for Bone Tissue Engineering

2016 ◽  
pp. 104-132
Author(s):  
Ozan Karaman ◽  
Cenk Celik ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Engineering Applications ◽  
Temporal Regulation ◽  
Biomimetic Scaffolds ◽  
Self Assembled

Cranial, maxillofacial, and oral fractures, as well as large bone defects, are currently being treated by auto- and allograft procedures. These techniques have limitations such as immune response, donor-site morbidity, and lack of availability. Therefore, the interest in tissue engineering applications as replacement for bone graft has been growing rapidly. Typical bone tissue engineering models require a cell-supporting scaffold in order to maintain a 3-dimensional substrate mimicking in vivo extracellular matrix for cells to attach, proliferate and function during the formation of bone tissue. Combining the understanding of molecular and structural biology with materials engineering and design will enable new strategies for developing biological tissue constructs with clinical relevance. Self-assembled biomimetic scaffolds are especially suitable as they provide spatial and temporal regulation. Specifically, self-assembling peptides capable of in situ gelation serve as attractive candidates for minimally invasive injectable therapies in bone tissue engineering applications.

Self-Assembled Organic Nanotubes: Novel Bionanomaterials for Orthopedics and Tissue Engineering

2017 ◽  
pp. 19-46
Author(s):  
Rachel L. Beingessner ◽  
Baljit Singh ◽  
Thomas J. Webster ◽  
Hicham Fenniri
Keyword(s):  
Tissue Engineering ◽  
Self Assembled ◽  
Organic Nanotubes
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