Enhanced Synthesis of oxo-Verdazyl Radicals Bearing Sterically-and Electronically-Diverse C3-Substitents

2021 ◽  
Author(s):  
Rebecca Olivia Fuller ◽  
Madeleine Taylor ◽  
Margot Duggin ◽  
Alex C. Bissember ◽  
Allan J. Canty ◽  
...  
Keyword(s):  
Aryl Substituent ◽  
Verdazyl Radicals

The synthetic viability of the hydrazine- and phosgene-free synthesis of 1,5-dimethyl oxo-verdazyl radicals has been improved via a detailed study investigating the influence of the aryl substituent on the tetrazinanone...

Magnetic properties of a new type of 1,5-diphenyl-6-oxo- and -thioxo-verdazyl radicals

1995 ◽  
Vol 241 (5-6) ◽  
pp. 618-622 ◽  
Author(s):  
Kazuo Mukai ◽  
Syuji Kawasaki ◽  
Javad B. Jamali ◽  
Norio Achiwa
Keyword(s):  
Magnetic Properties ◽  
Verdazyl Radicals ◽  
New Type

EPR of single-crystal and polycrystalline specimens of verdazyl radicals

1982 ◽  
Vol 22 (5) ◽  
pp. 667-670
Author(s):  
L. S. Podenko ◽  
A. K. Chirkov ◽  
V. E. Petroshen' ◽  
V. P. Schchipanov
Keyword(s):  
Single Crystal ◽  
Verdazyl Radicals

Kinetics and Mechanism of Isocyanide-Promoted Carbene Insertion into the Aryl Substituent of an N-Heterocyclic Carbene Ligand in Ruthenium-Based Metathesis Catalysts

2017 ◽  
Vol 36 (16) ◽  
pp. 3043-3052 ◽  
Author(s):  
Justin R. Griffiths ◽  
Elan J. Hofman ◽  
Jerome B. Keister ◽  
Steven T. Diver
Keyword(s):  
Kinetics And Mechanism ◽  
Aryl Substituent ◽  
Carbene Insertion ◽  
Metathesis Catalysts

scholarly journals The effects of introducing sterically demanding aryl substituents in [Cu(N^N)(P^P)]+ complexes

2017 ◽  
Vol 46 (19) ◽  
pp. 6379-6391 ◽  
Author(s):  
Fabian Brunner ◽  
Stefan Graber ◽  
Yann Baumgartner ◽  
Daniel Häussinger ◽  
Alessandro Prescimone ◽  
...  
Keyword(s):  
Aryl Substituent ◽  
Sterically Demanding ◽  
Sterically Hindered

[Cu(6-Arbpy)(POP)][PF6] and [Cu(6-Arbpy)(xantphos)][PF6] compounds in which Ar is a sterically hindered aryl substituent are described; structural and solution dynamical consequences of the bulky groups are investigated.

Skeleton transformation of α-pyrone induced by 5-aryl substituent into ring-fused dihydrofuran

2014 ◽  
Vol 55 (9) ◽  
pp. 1536-1539 ◽  
Author(s):  
Takuya Miura ◽  
Saki Fujioka ◽  
Hiroki Iwasaki ◽  
Minoru Ozeki ◽  
Naoto Kojima ◽  
...  
Keyword(s):  
Aryl Substituent

The syntheses, structures and spectroelectrochemical properties of 6-oxo-verdazyl derivatives bearing surface anchoring groups

2022 ◽  
Author(s):  
Varshini Jayantha Kumar ◽  
Jian-Zhong Wu ◽  
Martyna Judd ◽  
Elodie ROUSSET ◽  
Marcus Korb ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Terminal Alkynes ◽  
Bearing Surface ◽  
Surface Anchoring ◽  
Verdazyl Radicals ◽  
Cross Coupling Reactions ◽  
Anchoring Groups ◽  
Spectroelectrochemical Properties

A series of 6-oxo verdazyl radicals functionalised at the 1- and 5-positions by methyl, thiomethyl and iodo groups were synthesised using conventional strategies. Facile Sonogashira cross-coupling reactions of terminal alkynes...

Morpholines-(IV)

1971 ◽  
Vol 26 (11) ◽  
pp. 1140-1143 ◽  
Author(s):  
Riaz F. Abdulla ◽  
Alok N. Bannerji
Keyword(s):  
Nmr Spectroscopy ◽  
Nmr Spectra ◽  
Beta Lactams ◽  
Aryl Substituent ◽  
Open Chain ◽  
H Nmr

Cyclodehydrohalogenation-beta-Lactams-Morpholin-3-ones-H'-NMR SpectroscopyN-Aryl-N-chloroacetyl-2-chlorophenacylamines (2) give morpholinones 3, or beta-lactams 4, depending upon the N-aryl-substituent. N-Phenyl-N- (2,3-dibromo-3-phenylpropionyl) -4-nitrophenacylamine did not undergo base-catalysed cyclization but gave, instead, the α,β-unsaturated, open-chain amide 5. N-Aryl-N-chloroacetyl-aminomethyl-2-naphthylketones afford only beta-lactams. The first attempt at the synthesis of a 2-chloro-3-oxo-morpholine resulted in the isolation of the 2-hydroxyderivative. The H1-NMR spectra of some more 3-oxo-morpholines have been recorded.

scholarly journals Thieno[2,3-b)pyridinones as Antagonists on the Glycine Site of the N-methyl-ᴅ-aspartate Receptor - Binding Studies, Molecular Modeling and structure-Activity-Relationships

2000 ◽  
Vol 68 (1) ◽  
pp. 1-14 ◽  
Author(s):  
H.-P. Buchstaller ◽  
C.D. Siebert ◽  
R.H. Lyssy ◽  
G. Ecker ◽  
M. Krug ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Phenyl Ring ◽  
Parent Compound ◽  
Aryl Substituent ◽  
Binding Studies ◽  
Torsion Angles ◽  
Qsar Studies ◽  
Aspartate Receptor ◽  
Structure Activity ◽  
Ortho Substituent

Within the frame of the synthesis of glycine antagonists, a series of novel thieno[2,3- b]pyridinones with substituted phenyl residues in position 5 were synthesised to investigate the importance of the torsion angle between the pyridinone skeleton and the phenyl ring for binding affinity. The parent compound, 4-hydroxy-5-phenylthieno[2,3-b]pyridine-6(7H)-one, and its thienyl analogue, exhibited highest potencies, whereas compounds with ortho-substituted aryl moieties in position 5 showed decreased activities. This seems to be due to unfavourable steric interactions and increased torsion angles between the thieno[2,3- b]pyridinone system and the aryl substituent in position 5. Further evidence is drawn by QSAR studies, which showed an inverse relationship between the size of the ortho-substituent and the binding affinity.

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