Biomimetic Smart Nanoplatform for Dual Imaging-Guided Synergistic Cancer Therapy

2022 ◽  
Author(s):  
Yanfei Shen ◽  
Zhengzou Fang ◽  
Erli Yang ◽  
Ying Du ◽  
Daqing Gao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapy Outcome ◽  
Highly Efficient ◽  
Dual Imaging

Developing an integrated multimodal diagnosis and therapeutics nanoplatform is of great importance to enhance the cancer therapy outcome. Herein, we report a highly efficient and biocompatible nanoplatform based on the...

scholarly journals Self-assembled porphyrin polymer nanoparticles with NIR-II emission and highly efficient photothermal performance in cancer therapy

2022 ◽  
Vol 13 ◽  
pp. 100198
Author(s):  
Cheng Li ◽  
Zijin Luo ◽  
Lixia Yang ◽  
Jun Chen ◽  
Kai Cheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymer Nanoparticles ◽  
Highly Efficient ◽  
Self Assembled

scholarly journals Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy

Biomaterials ◽  
2016 ◽  
Vol 103 ◽  
pp. 75-85 ◽  
Author(s):  
Mirong Guan ◽  
Jiechao Ge ◽  
Jingyi Wu ◽  
Guoqiang Zhang ◽  
Daiqin Chen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Highly Efficient ◽  
Tumor Accumulation

A two-photon AIE fluorophore as a photosensitizer for highly efficient mitochondria-targeted photodynamic therapy

2020 ◽  
Vol 44 (22) ◽  
pp. 9355-9364 ◽  
Author(s):  
Qunshou Kong ◽  
Boxuan Ma ◽  
Tao Yu ◽  
Cheng Hu ◽  
Gaocan Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Two Photon ◽  
Highly Efficient ◽  
Targeted Photodynamic Therapy

Nowadays, photodynamic therapy (PDT) has become an effective method for cancer therapy.

A biodegradable multifunctional nanoplatform based on antimonene nanosheets for synergistic cancer phototherapy and dual imaging

2021 ◽  
Author(s):  
Xiaokang Jin ◽  
Chengfeng Xu ◽  
Jinhua Hu ◽  
Shuting Yao ◽  
Zhiwen Hu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Human Body ◽  
Severe Damage ◽  
Dual Imaging

Recently, nanomaterials have been well-studied in cancer therapy, but some of them often experience difficulties with degradation in vivo, which could cause severe damage to the human body. Among numerous...

“Stemness” Genomics Law Governs Clinical Behavior of Human Cancer: Implications for Decision Making in Disease Management

2008 ◽  
Vol 26 (17) ◽  
pp. 2846-2853 ◽  
Author(s):  
Gennadi V. Glinsky
Keyword(s):  
Cancer Therapy ◽  
Cancer Patients ◽  
Scientific Information ◽  
Embryonic Stem ◽  
Therapy Outcome ◽  
Chromatin Domain ◽  
Term Therapy ◽  
Practical Implementation ◽  
Cancer Therapies ◽  
Clinical Behavior

One of the most significant accomplishments of translational oncogenomics is a realistic promise of efficient diagnostic tests that would facilitate implementation of the concept of individualized cancer therapies. Recent discovery of the BMI1 pathway rule indicates that gene expression signatures (GESs) associated with the “stemness” state of a cell might be informative as molecular predictors of cancer therapy outcome. We illustrate a potential clinical utility of this concept using GESs derived from genomic analysis of embryonic stem cells (ESCs) during transition from self-renewing, pluripotent state to differentiated phenotypes. Signatures of multiple stemness pathways (signatures of BMI1, Nanog/Sox2/Oct4, EED, and Suz12 pathways; transposon exclusion zones and ESC pattern 3 signatures; signatures of Polycomb-bound and bivalent chromatin domain transcription factors) seem informative in stratification of cancer patients into low- and high-intensity treatment groups on the basis of prediction of the long-term therapy outcome. A stemness cancer therapy outcome predictor (CTOP) algorithm combining scores of nine stemness signatures outperforms individual signatures and demonstrates a superior prognostic accuracy in retrospective supervised analysis of large cohorts of breast, prostate, lung, and ovarian cancer patients. Our analysis suggests that stemness genomics law governs clinical behavior of human malignancies and defines epigenetic boundaries of therapy-resistant and -sensitive tumors within distinct stemness/differentiation programs. One of the main conclusions of our analysis is that near-term progress in practical implementation of the concept of personalized cancer therapies would depend on timely delivery to practicing physicians of relevant scientific information regarding the outcome of prospective trials validating prognostic performance of CTOP tests in a clinical setting.

Deep tumor‐penetrated nanosystem eliminates cancer stem cell for highly efficient liver cancer therapy

2020 ◽  
pp. 127874
Author(s):  
Qiufang Chen ◽  
Bin Deng ◽  
Qing Luo ◽  
Guanbin Song
Keyword(s):  
Stem Cell ◽  
Cancer Therapy ◽  
Liver Cancer ◽  
Cancer Stem Cell ◽  
Highly Efficient

Highly Efficient and Safe Delivery of VEGF siRNA by Bioreducible Fluorinated Peptide Dendrimers for Cancer Therapy

2017 ◽  
Vol 9 (11) ◽  
pp. 9402-9415 ◽  
Author(s):  
Xiaojun Cai ◽  
Haofang Zhu ◽  
Yanmei Zhang ◽  
Zhongwei Gu
Keyword(s):  
Cancer Therapy ◽  
Safe Delivery ◽  
Highly Efficient ◽  
Peptide Dendrimers

scholarly journals Mitochondria-Targeted Nanocarriers Promote Highly Efficient Cancer Therapy: A Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Zeng Zeng ◽  
Chao Fang ◽  
Ying Zhang ◽  
Cong-Xian Chen ◽  
Yi-Feng Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Cancer Treatment ◽  
Therapeutic Agents ◽  
Sonodynamic Therapy ◽  
Therapeutic Modalities ◽  
Normal Functions ◽  
The Past ◽  
Highly Efficient ◽  
Apoptotic Pathways ◽  
Mitochondria Targeting

Mitochondria are the primary organelles which can produce adenosine triphosphate (ATP). They play vital roles in maintaining normal functions. They also regulated apoptotic pathways of cancer cells. Given that, designing therapeutic agents that precisely target mitochondria is of great importance for cancer treatment. Nanocarriers can combine the mitochondria with other therapeutic modalities in cancer treatment, thus showing great potential to cancer therapy in the past few years. Herein, we summarized lipophilic cation- and peptide-based nanosystems for mitochondria targeting. This review described how mitochondria-targeted nanocarriers promoted highly efficient cancer treatment in photodynamic therapy (PDT), chemotherapy, combined immunotherapy, and sonodynamic therapy (SDT). We further discussed mitochondria-targeted nanocarriers’ major challenges and future prospects in clinical cancer treatment.

Hybrid MoSe2–indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy

2018 ◽  
Vol 6 (6) ◽  
pp. 1503-1516 ◽  
Author(s):  
Jingqin Chen ◽  
Xueshen Li ◽  
Xiaoyang Liu ◽  
Huixiang Yan ◽  
Zhihua Xie ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Indocyanine Green ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Highly Efficient

The synthesis of sMoSe2–ICG NSs for highly efficient tumor photoacoustic imaging guided photothermal therapy.

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