scholarly journals The effect of hexokinase and tricarboxylic acid-cycle intermediates on fatty acid oxidation and formation of ketone bodies by rat-liver mitochondria

1966 ◽  
Vol 98 (2) ◽  
pp. 389-393 ◽  
Author(s):  
FJR Hird ◽  
RH Symons ◽  
MJ Weidemann
Keyword(s):  
Fatty Acid ◽  
Rat Liver ◽  
Ketone Bodies ◽  
Tricarboxylic Acid Cycle ◽  
Liver Mitochondria ◽  
Tricarboxylic Acid ◽  
Rat Liver Mitochondria ◽  
Acid Oxidation ◽  
Acid Cycle ◽  
Tricarboxylic Acid Cycle Intermediates

UTILIZATION OF LIPIDS BY FISH: II. FATTY ACID OXIDATION BY A PARTICULATE FRACTION FROM LATERAL LINE MUSCLE

1964 ◽  
Vol 42 (3) ◽  
pp. 345-352 ◽  
Author(s):  
E. Bilinski ◽  
R. E. E. Jonas
Keyword(s):  
Fatty Acid ◽  
Rainbow Trout ◽  
Fatty Acid Oxidation ◽  
Lateral Line ◽  
Sockeye Salmon ◽  
Tricarboxylic Acid Cycle ◽  
Tricarboxylic Acid ◽  
Acid Oxidation ◽  
Acid Cycle ◽  
Tricarboxylic Acid Cycle Intermediates

The fatty acid oxidizing system present in lateral line muscle of rainbow trout (Salmo gairdnerii) and sockeye salmon (Oncorhynchus nerka) was studied by using subcellular particles, having the sedimentation characteristics of mitochondria. The rate of oxidation of K-myristate-1-C14, K-octanoate-1-C14, and Na-hexanoate-1-C14 was determined at 25 °C by measuring the formation of C14O2. Oxidation was stimulated by adenosine triphosphate Mg++, coenzyme A and tricarboxylic acid cycle intermediates, but not by cytochrome c. It was optimum at pH 7.5–8.5.The data are consistent with the assumption that in the lateral line muscle fatty acid oxidation takes place through the known mechanism involving CoA derivatives.

Biochemical studies on ovine pregnancy toxaemia. I. Enzymic activities of liver and brain

1959 ◽  
Vol 10 (6) ◽  
pp. 854 ◽  
Author(s):  
CH Gallagher
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Tricarboxylic Acid Cycle ◽  
Liver Mitochondria ◽  
Tricarboxylic Acid ◽  
Acid Oxidation ◽  
Enzyme Preparations ◽  
Acid Cycle ◽  
Sheep Liver ◽  
Pregnancy Toxaemia

Enzymic activities in vitro of liver and brain tissue of sheep with pregnancy toxaemia were measured. Anaerobic glycolysis and oxidations of tricarboxylic acid cycle intermediates and related substrates were normal for both brain and liver enzyme preparations. Fatty acid oxidation by liver mitochondria was abnormal. Liver mitochondria from cases of pregnancy toxaemia were invariably incapable of oxidizing octanoate and palmitate, and frequently unable to oxidize propionate. The rate of propionate oxidation was low even when this substrate was oxidized. Butyrate oxidation was not much reduced by pregnancy toxaemia. Starvation of ewes in late pregnancy did not inactivate the fatty acid oxidation chains of liver mitochondria. Possible reasons for the failure of lipid metabolism are discussed. The dependence of sheep liver metabolism upon fatty acid oxidation is discussed. Insignificant amounts of glucose are absorbed from the alimentary canal in sheep and, even if absorbed, are not catabolized to supply acetyl coenzyme A for oxidation in the tricarboxylic acid cycle. Consequently sheep liver is prone to failure from interference with fatty acid oxidation. Pregnancy toxaemia is discussed in relevance to the disturbance of fatty acid metabolism which is thought to be of considerable significance in the disease.

scholarly journals Detection of myocardial medium‐chain fatty acid oxidation and tricarboxylic acid cycle activity with hyperpolarized [1– 13 C]octanoate

2020 ◽  
Vol 33 (3) ◽  
Author(s):  
Hikari A.I. Yoshihara ◽  
Jessica A.M. Bastiaansen ◽  
Magnus Karlsson ◽  
Mathilde H. Lerche ◽  
Arnaud Comment ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Tricarboxylic Acid Cycle ◽  
Tricarboxylic Acid ◽  
Chain Fatty Acid ◽  
Medium Chain Fatty Acid ◽  
Acid Oxidation ◽  
Acid Cycle ◽  
Medium Chain
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