scholarly journals The effects of inhibition of gluconeogenesis in suckling newborn rats

1977 ◽  
Vol 162 (1) ◽  
pp. 209-212 ◽  
Author(s):  
P Ferre ◽  
J P Pegorier ◽  
J Girard
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Ketone Bodies ◽  
Plasma Free Fatty Acid ◽  
High Plasma ◽  
Normal Blood ◽  
Newborn Rats ◽  
High Concentrations ◽  
Blood Ketone Bodies

Inhibition of gluconeogenesis with 3-mercaptopicolinate in suckling newborn rats caused a fall in blood [glucose], but no change in their high plasma [free fatty acid] and blood [ketone bodies]. Active gluconeogenesis seems to be more important than sparing of glucose by high concentrations of fat-derived substrates for the maintenance of normal blood [glucose] in suckling newborn rats.

scholarly journals The effects of inhibition of fatty acid oxidation in suckling newborn rats

1977 ◽  
Vol 166 (3) ◽  
pp. 631-634 ◽  
Author(s):  
J P Pégorier ◽  
P Ferré ◽  
J Girard
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Fatty Acid Oxidation ◽  
Glucose Utilization ◽  
Ketone Bodies ◽  
Normal Blood ◽  
Acid Oxidation ◽  
Newborn Rats ◽  
Normal Blood Glucose ◽  
Blood Ketone Bodies

Inhibition of fatty acid oxidation with pent-4-enoate in suckling newborn rats caused a fall in blood [glucose] and blood [ketone bodies] and inhibition of gluconeogenesis from lactate. Glucose utilization was not increased in newborn rats injected with pent-4-enoate. Active fatty acid oxidation appears to be essential to support gluconeogenesis and to maintain normal blood [glucose] in suckling newborn rats.

Effects of Carbohydrate and Chromium Ingestion during Intermittent High-Intensity Exercise to Fatigue

2000 ◽  
Vol 10 (4) ◽  
pp. 476-485 ◽  
Author(s):  
J. Mark Davis ◽  
Ralph S. Welsh ◽  
Nathan A. Alderson
Keyword(s):  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Fatigue Test ◽  
Exercise Capacity ◽  
High Intensity ◽  
Plasma Free Fatty Acid ◽  
Chromium Picolinate ◽  
Double Blind ◽  
Physically Active

Purpose:This study was designed to test the hypothesis that addition of chromium (Cr) to a carbohydrate-electrolyte drink would enhance the reported benefits of carbohydrate on exercise capacity during intermittent high-intensity shuttle running.Methods:Eight physically active men performed 3 exercise trials while ingesting 6% carbohydrate-electrolyte (CHO), CHO plus chromium picolinate (400 μg) (CHO + Cr+3). or placebo (P) using a double-blind, counterbalanced design. Each trial consisted of 5 × 15 min bouts of shuttle running (walk, sprint, and run at 95 and 55% of estimated V̇O2max, separated by 3-min rest). This was followed by a fatigue test (running alternating 20-m lengths at 55 and 95% of estimated V̇O2, until fatigue).Results:During the standardized shuttle running, blood glucose was higher with both CHO and CHO + Cr+3 than P. Plasma free fatty acid was higher in P than both CHO and CHO + Cr+3 at 75 min of exercise and at fatigue. In the fatigue test, subjects ran longer with both CHO and CHO + Cr+3 than P.Conclusions:The data confirm an ergogenic benefit of ingesting CHO during exercise designed to imitate sports like basketball, soccer, and hockey, but do not support the hypothesis that the addition of Cr would enhance this effect.

Effect of glucagon on thermogenesis in the pigeon.

1977 ◽  
Vol 232 (5) ◽  
pp. E451
Author(s):  
E Hohtola ◽  
R Hissa ◽  
S Saarela
Keyword(s):  
Oxygen Consumption ◽  
Fatty Acid ◽  
Blood Glucose ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Energy Reserves ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Plasma Ffa ◽  
Adrenergic Blocking

The effects of glucagon injection on temperature regulation and some metabolic parameters were studied in the pigeon. Glucagon (100 microng/kg) always inhibited shivering and caused a fall in the oxygen consumption and body temperature of the unanesthetized pigeon at + 6 degrees C. At + 34 degrees C, the same dose of glucagon had no effect on these parameters. At 22 degrees C, glucagon produced an elevation in plasma free fatty acid (FFA) and blood glucose levels. The rise in FFA at 22 degrees C coincided with the suppression of shivering at 6 degrees C. The glucagon-mediated rise in plasma FFA, but not glucose level, was potentiated by cold ambient temperature. Adrenergic blocking agents given prior to glucagon did not abolish its effects. Phentolamine even prolonged the absence and accelerated the suppression of shivering. A dissociation in the mechanisms by which catecholamines and glucagon suppress shivering is suggested. Although mobilizing energy reserves, glucagon does not seem to be calorigenic in the pigeon at this dose. The interpretation of the changes in plasma FFA levels is discussed in relation to fuel consumption during shivering.

High Plasma Free Fatty Acid Levels Contribute to the Hypersomatostatinemia of Insulin Deficiency

Diabetes ◽  
1981 ◽  
Vol 30 (4) ◽  
pp. 358-361 ◽  
Author(s):  
T. Wasada ◽  
B. Howard ◽  
K. McCorkle ◽  
V. Harris ◽  
R. H. Unger
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
High Plasma ◽  
Insulin Deficiency
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